- Faecal transplants from young mice replenishes the gut microbiome and boosts the gut immune system in older mice.
- The study demonstrates that the decline in the gut immune response due to age is not irreversible and that it can be boosted in older individuals.
- The gut microbiome could be a target for the treatment of a range of age-associated symptoms to facilitate healthy ageing.
Faecal transplants from young to aged mice can stimulate the gut microbiome and revive the gut immune system, a study by immunologists at the Institute has shown. The research is published in the journal Nature Communications today.
The gut is one of the organs that is most severely affected by ageing and age-dependent changes to the human gut microbiome have been linked to increased frailty, inflammation and increased susceptibility to intestinal disorders. These age-dependent changes to the gut microbiome happen in parallel with a decrease in function of the gut immune system but, until now, it was unknown whether the two changes were linked.
“Our gut microbiomes are made up of hundreds of different types of bacteria and these are essential to our health, playing a role in our metabolism, brain function and immune response,” explains lead researcher Dr Marisa Stebegg. “Our immune system is constantly interacting with the bacteria in the gastrointestinal tract. As immunologists who study why our immune system doesn’t work as well as we age, we were interested to explore whether the make-up of the gut microbiome might influence the strength of the gut immune response.”
Co-housing young and aged mice (mice naturally like to sample the faecal pellets of other mice!) or more directly performing faecal transfer from young to aged mice boosted the gut immune system in the aged mice, partly correcting the age-related decline.
“To our surprise, co-housing rescued the reduced gut immune response in aged mice. Looking at the numbers of the immune cells involved, the aged mice possessed gut immune responses that were almost indistinguishable from those of the younger mice.” commented Dr Michelle Linterman, group leader in the Immunology programme at the Babraham Institute.
The results show that the poor gut immune response is not irreversible and that the response can be strengthened by challenging with appropriate stimuli, essentially turning back the clock on the gut immune system to more closely resemble the situation in a young mouse.
The results of the study have relevance for treating age-related symptoms, confirming a link between the effects of the ageing immune system and age-associated changes in the gut microbiome. By demonstrating the effectiveness of interventions that have a positive impact on the composition of the gut microbiome, this research suggests that faecal transplants, probiotics, co-habitation and diet might all prove to be ways to facilitate healthy ageing.
The Latest on: Gut microbiome
via Google News
The Latest on: Gut microbiome
- Scientists reveal how gut microbes can influence bone strength in miceon January 12, 2021 at 7:48 am
Gut microbes passed from female mice to their offspring, or shared between mice that live together, may influence the animals' bone mass, says a new study published today in .
- Study finds link between gut microbes and Type 2 diabeteson January 12, 2021 at 6:54 am
A diet rich in healthy and plant-based foods is linked with the presence and abundance of certain gut microbes that are also associated with a lower risk of developing conditions such as obesity, Type ...
- Bacteria in your GUT 'affects Covid-19 severity'on January 12, 2021 at 4:22 am
A review study from South Korea and a real-world study from China determined the gut microbiome plays a role in coronavirus disease severity.
- New Study Suggests That Healthy Gut Bacteria Could Help to Prevent Severe Cases of Covidon January 12, 2021 at 3:35 am
A new study links the length and severity of a person's experience of COVID-19 with the state of their gut microbiome ; There are also potential implications for who goes on to ex ...
- Want to Get Healthier this Year? Go with Your Gut | Opinionon January 12, 2021 at 2:00 am
Why not make 2021 the year you revolutionize your health from the inside out, by supporting the trillions of bacteria living in your gut?
- Gut microbiome imbalances influence the likelihood of ‘long Covid’on January 12, 2021 at 12:42 am
A recent study has shown that imbalances in the type and volume of bacteria found in the gut may be associated with the risk of 'long COVID’.
- Gut microbiome may influence COVID-19 severityon January 11, 2021 at 10:07 pm
The variety and volume of bacteria in the gut known as the microbiome may influence the severity of COVID-19 as well as the magnitude of the immune system res ...
- COVID-19 severity linked to gut bacteria in first-of-its-kind studyon January 11, 2021 at 4:24 pm
A first-of-its-kind study has investigated the relationship between COVID-19 severity and the gut microbiome. The observational research suggests specific microbial patterns correlate with disease ...
- Gut Microbiome and COVID-19 Severity: New Evidence for Linkon January 11, 2021 at 3:33 pm
The gut microbiome may play a role in COVID-19 severity, a lab study suggested. Patients with depleted levels of certain species of bacteria were associated with elevated concentrations of ...
- Make-up of gut microbiome may influence COVID-19 severity and immune responseon January 11, 2021 at 3:32 pm
The variety and volume of bacteria in the gut, known as the microbiome, may influence the severity of COVID-19 as well as the magnitude of the immune system response to the infection, suggests ...
via Bing News