A new type of treatment for osteoarthritis, currently in canine clinical trials, shows promise for eventual use in humans.
The treatment, developed by Cornell biomedical engineers, is a synthetic version of a naturally occurring joint lubricant that binds to the surface of cartilage in joints and acts as a cushion during high-impact activities, such as running.
“When the production of that specific lubricant goes down, it creates higher contact between the surfaces of the joint and, over time, it leads to osteoarthritis,” said David Putnam, a professor in the College of Engineering with appointments in the Meinig School of Biomedical Engineering and the Smith School of Chemical and Biomolecular Engineering.
Putnam is senior author of “Boundary Mode Lubrication of Articular Cartilage With a Biomimetic Diblock Copolymer,” published June 4 in Proceedings of the National Academy of Sciences, USA. Zhexun Sun, a postdoctoral researcher in Putnam’s lab, is the paper’s first author.
The study focuses on a naturally occurring joint lubricant called lubricin, the production of which declines following traumatic injuries to a joint, such as a ligament tear in a knee.
The knee is lubricated in two ways – hydrodynamic mode and boundary mode.
Hydrodynamic mode lubrication occurs when the joint is moving fast and there isn’t a strong force pushing down on it. In this mode, joints are lubricated by compounds like hyaluronic acid (HA) that are thick and gooey, like car oil. There are numerous HA products on the market, approved by the Food and Drug Administration, for treating hydrodynamic mode lubrication disorders.
But HA is ineffective when strong forces are pushing down on the joint, such as those that occur during running or jumping. In these instances, thick gooey HA squirts out from between the cartilage surfaces, and boundary mode lubrication is necessary. Under these forces, lubricin binds to the surface of the cartilage. It contains sugars that hold on to water, to cushion hard forces on the knee.
In the paper, the researchers describe a synthetic polymer they developed that mimics the function of lubricin and is much easier to produce. “We are in clinical trials, with dogs that have osteoarthritis, with our collaborators at Cornell’s College of Veterinary Medicine,” Putnam said.
Those collaborators – Ursula Krotscheck and Kei Hayashi, both associate professors in the Section of Small Animal Surgery in the Department of Clinical Sciences – use a force plate to measure the efficacy of the treatments. The force plate quantifies the amount of force that a dog exerts with each paw, to measure whether they are favoring one paw over another.
“Once we finalize the efficacy study in dogs, we will be in a very good position to market the material for veterinary osteoarthritis treatment,” Putnam said. From there, the human market for a lubricin substitute should follow, just as HA has been made available for human use, mainly in knees.
The Latest on: Osteoarthritis
[google_news title=”” keyword=”osteoarthritis” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Osteoarthritis
- Ask Dr Rosemary Leonard: “Is a hip replacement the only cure for osteoarthritis?"on February 29, 2024 at 6:35 am
He visited the GP, who sent him for an X-ray, and was advised he had osteoarthritis in his hip. A consultant said he needed a hip replacement. We were surprised as friends who have had this operation ...
- Glucosamine and Chondroitin, for Hip or Knee Osteoarthritison February 28, 2024 at 3:59 pm
Randomized trials on the effectiveness of glucosamine and chondroitin for osteoarthritis (OA) have yielded mixed results; the largest trial showed no benefit for these agents, used alone or in ...
- Calcium crystal deposits in the knee found to contribute to joint damageon February 28, 2024 at 12:23 pm
Knee osteoarthritis (OA) is the most common form of arthritis, affecting approximately 600 million people worldwide and 34 million people in the U.S. There are no treatments available that prevent its ...
- Calcium crystal deposits linked to worsening knee osteoarthritis, study findson February 28, 2024 at 10:50 am
Knee osteoarthritis (OA) is the most common form of arthritis, affecting approximately 600 million people worldwide and 34 million people in the U.S.
- The Animal Center in Zachary offers free screenings for cat osteoarthritison February 27, 2024 at 5:00 am
In honor of National Cat Health Month, The Animal Center Inc. is offering free cat osteoarthritis screenings to pet owners interested in enrolling their cat in a clinical study for ...
- Free Osteoarthritis screening for your cat during National Cat Health Monthon February 26, 2024 at 2:34 am
February is National Cat Health Month. Here in central Ohio, two local vet offices are offering free health screenings to your feline friend.
- Technology Insight: Adult Mesenchymal Stem Cells for Osteoarthritis Therapyon February 25, 2024 at 3:59 pm
Despite the high prevalence and morbidity of osteoarthritis (OA), an effective treatment for this disease is currently lacking. Restoration of the diseased articular cartilage in patients with OA ...
- Using your nose to regenerate knees eroded by osteoarthritison February 22, 2024 at 11:38 pm
Having already demonstrated that a small amount of cartilage taken from the nose can be used to repair injured knees, researchers will soon commence a clinical trial to investigate whether the ...
- Osteoarthritis is more common than you think: How to treat and prevent it from worseningon February 19, 2024 at 3:00 am
Osteoarthritis affects everyone on the planet, particularly as we get older. The condition is caused by wear and tear on the protective layer of cartilage on the ends of our bones — not unlike wearing ...
- What Are The Best Foods To Eat For Osteoarthritis? A Review By Doctorson February 18, 2024 at 1:43 pm
The following foods may help delay the onset or progression of osteoarthritis: fruits and vegetables, which provide antioxidants; low-fat dairy foods, which contain calcium and vitamin D and healthy ...
via Bing News