Gladstone Institutes

The Gladstone Institutes is an independent and nonprofit biomedical research organization whose focus is to better understand, prevent, treat and cure cardiovascular, viral and neurological conditions such as heart failure, HIV/AIDS and Alzheimer’s disease.

A potential therapy for heart valve disease

Mass rapid testing moves closer with a new CRISPR-based test for COVID-19 using a smartphone

CRISPR gene editing gets an on switch for better control

CRISPR-Cas9 is a revolutionary tool in part because of its versatility: created by bacteria to chew up viruses, it works equally well in human cells to do all sorts of genetic tricks, including cutting and pasting DNA, making pinpoint mutations and activating or inactivating a gene. UC Berkeley researchers have now made it even more

CRISPR gene editing gets an on switch for better control

A promising new way to fight tuberculosis?

Scientists in the San Francisco Bay Area identify nearly 200 potential drug targets Tuberculosis is one of the top 10 causes of death worldwide. Nearly 2 million people die every year from this infectious disease, and an estimated 2 billion people are chronically infected. The only vaccine, developed almost 100 years ago, offers limited protection

A promising new way to fight tuberculosis?

Transplanting a special type of neuron into the brain restores cognitive functions in Alzheimer’s models

Like a great orchestra, your brain relies on the perfect coordination of many elements to function properly. And if one of those elements is out of sync, it affects the entire ensemble. In Alzheimer’s disease, for instance, damage to specific neurons can alter brainwave rhythms and cause a loss of cognitive functions. One type of

Transplanting a special type of neuron into the brain restores cognitive functions in Alzheimer’s models

Drug discovery made cheaper, quicker and more reliable

Li Gan, PhD, wants to find treatments to help patients with Alzheimer’s disease. Like most researchers, she’s hit a few major roadblocks. When researchers like Gan find potential new drugs, it’s useful to test them on human cells to increase the chances that they will benefit patients. Historically, these tests have been conducted in cancer cells,

Drug discovery made cheaper, quicker and more reliable

A key cellular protein could lead to treatments for neurodegenerative diseases

A new way to regulate protein levels and functions could be the answer to treating devastating neurological conditions New details learned about a key cellular protein could lead to treatments for neurodegenerative diseases, such as Parkinson’s, Huntington’s, Alzheimer’s, and amyotrophic lateral sclerosis (ALS). At their root, these disorders are triggered by misbehaving proteins in the

A key cellular protein could lead to treatments for neurodegenerative diseases

Direct cardiac reprogramming to benefit from heart cells that are better, faster, stronger

Two chemicals improved the speed, quantity, and quality of direct cardiac reprogramming, bringing the technology one step closer to regenerating damaged hearts Scientists at the Gladstone Institutes identified two chemicals that improve their ability to transform scar tissue in a heart into healthy, beating heart muscle. The new discovery advances efforts to find new and

Direct cardiac reprogramming to benefit from heart cells that are better, faster, stronger

Scientists Turn Skin Cells into Heart Cells and Brain Cells Using Drugs

In a major breakthrough, scientists at the Gladstone Institutes transformed skin cells into heart cells and brain cells using a combination of chemicals. All previous work on cellular reprogramming required adding external genes to the cells, making this accomplishment an unprecedented feat. The research lays the groundwork for one day being able to regenerate lost

Scientists Turn Skin Cells into Heart Cells and Brain Cells Using Drugs

Combining the two most powerful biological tools of the 21st century to Control Gene Expression in Stem Cells – CRISPRi

Combining the two most powerful biological tools of the 21st century, scientists at the Gladstone Institutes have modified how the genome of induced pluripotent stem cells (iPSCs) is read for the first time using a variation of the CRISPR-Cas9 system. The development offers a major technological advance in creating cell models of genetic diseases. In

Combining the two most powerful biological tools of the 21st century to Control Gene Expression in Stem Cells – CRISPRi

Gladstone scientists discover potential new treatment for multiple sclerosis

Finding could have implications for other autoimmune disorders, such as type I diabetes Scientists from the Gladstone Institutes have discovered a way to prevent the development of multiple sclerosis (MS) in mice. Using a drug that blocks the production of a certain type of immune cell linked to inflammation and autoimmunity, the researchers successfully protected

Gladstone scientists discover potential new treatment for multiple sclerosis

Transplantation of healthy new brain cells reverses learning and memory loss in Alzheimer’s disease model

A new study from the Gladstone Institutes has revealed a way to alleviate the learning and memory deficits caused by apoE4, the most important genetic risk factor for Alzheimer’s disease, improving cognition to normal levels in aged mice. In the study, which was conducted in collaboration with researchers at UC San Francisco and published today

Transplantation of healthy new brain cells reverses learning and memory loss in Alzheimer’s disease model

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At home, on your phone, results in minutes: how Covid has changed the future of health tests
on April 8, 2021 at 6:59 pm
“That’s when we really knew we needed to ramp up our efforts and create something,” said Parinaz Fozouni, a UCSF doctoral candidate and graduate student in Melanie Ott’s lab at the Gladstone ...
Gladstone Land Snaps Up Olive Orchard For $37.8M; Street Sees 11% Upside
on April 6, 2021 at 7:37 am
Real estate investment trust Gladstone Land Corp. has acquired 2,285 acres of olive orchard in California for $37.8 million from Solum Partners. The company acquires farms and related properties ...
For Five Years, Trump Outrage Has Fueled Media Profits. So Now What?
on April 5, 2021 at 11:00 pm
Figures compiled by Heidi Legg, a journalist and a research fellow at Harvard’s Institute for Quantitative Social Science ... In his interview with Brooke Gladstone, McKay Coppins spoke ruefully about ...
Bay Area researchers probe how coronavirus attacks the heart
on April 3, 2021 at 7:07 am
SAN FRANCISCO (KGO) -- Researchers at San Francisco's Gladstone Institutes are focusing in ... Researchers at Gladstone are now hoping their cell research could also help identify potential ...
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms
on April 2, 2021 at 5:00 pm
David Gladstone Institutes, San Francisco ... CA 94158, USA. 38 Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA. 39 The University of California, ...

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Global CRISPR and CRISPR-associated (Cas) Genes...
on April 1, 2021 at 1:44 am
Genes Market - Growth, Trends, COVID-19 Impact, and Forecasts (2021 - 2026)" report has been added to ResearchAndMarkets.com's offering. The CRISPR and CRISPR-associated (Cas) Genes Market was ...
Global CRISPR and CRISPR-associated (Cas) Genes Market to 2026 with Profiles of OriGene Technologies, Thermo Fisher Scientific, Takara Bio, Horizon Di
on April 1, 2021 at 1:44 am
Genes Market - Growth, Trends, COVID-19 Impact, and Forecasts (2021 - 2026)" report has been added to ResearchAndMarkets.com's offering. The CRISPR and CRISPR-associated (Cas) Genes Market was ...
OceanaGold Reports Mineral Resource and Reserve for the Year-Ended 2020
on March 31, 2021 at 5:34 am
NOT FOR DISSEMINATION OR DISTRIBUTION IN THE UNITED STATES AND NOT FOR DISTRIBUTION TO US NEWSWIRE SERVICES./ MELBOURNE, Australia, March ...
Freaky New Feature Detected in Jupiter’s Northern Lights
on March 29, 2021 at 3:12 am
A newly detected auroral feature on Jupiter bears a striking resemblance to expanding smoke rings, in a discovery made possible by NASA’s Juno spacecraft. New research published in Journal of ...