
Nicole Steinmetz, UC San Diego professor of nanoengineering, holding an enlarged model of the Tobacco mild green mosaic virus. She is exploring how the plant virus could be used for targeted pesticide delivery deep within the soil. Photos by David Baillot/UC San Diego Jacobs School of Engineering
Imagine a technology that could target pesticides to treat specific spots deep within the soil, making them more effective at controlling infestations while limiting their toxicity to the environment.
Researchers at the University of California San Diego and Case Western Reserve University have taken a step toward that goal. They discovered that a biological nanoparticle—a plant virus—is capable of delivering pesticide molecules deeper below the ground, to places that are normally beyond their reach.
The work could help farmers better manage difficult pests, like parasitic nematodes that wreak havoc on plant roots deep in the soil, with less pesticide. The work is published May 20 in the journal Nature Nanotechnology.
“It sounds counterintuitive that we can use a plant virus to treat plant health,” said Nicole Steinmetz, a professor of nanoengineering at the UC San Diego Jacobs School of Engineering and senior author of the study. “This is an emerging field of research in nanotechnology showing that we can use plant viruses as pesticide delivery systems. It’s similar to how we’re using nanoparticles in medicine to target drugs towards sites of disease and reduce their side effects in patients.”
Pesticides are very sticky molecules when applied in the field, Steinmetz explained. They bind strongly to organic matter in the soil, making it difficult to get enough to penetrate deep down into the root level where pests like nematodes reside and cause damage.
To compensate, farmers end up applying large amounts of pesticides, which cause harmful residues to build up in the soil and leach into groundwater.
Steinmetz and her team are working to address this problem. In a new study, they discovered that a particular plant virus, Tobacco mild green mosaic virus, can transport small amounts of pesticide deep through the soil with ease.
A Helpful Virus
In lab tests, the researchers attached a model insecticide to different types of nanoparticles and watered them through columns of soil.
Tobacco mild green mosaic virus outperformed most of the other nanoparticles tested in the study. It carried its cargo down to 30 centimeters below the surface. PLGA and mesoporous silica nanoparticles, which researchers have studied for pesticide and fertilizer delivery, carried their payloads 8 and 12 centimeters deep, respectively.
Other plant viruses were also tested. Cowpea mosaic virus also carried its payload 30 centimeters deep below the surface, but it can only carry a fraction of the payload that Tobacco mild green mosaic virus can carry. Interestingly, Physalis mosaic virus only reached 4 centimeters below the surface.
The researchers hypothesize that nanoparticle geometry and surface chemistry could play a role in how it moves through the soil. For example, having a tubular structure might partly explain why Tobacco mild green mosaic virus travels farther than most of the other nanoparticles that are spherical in shape. Also, its surface chemistry is naturally more diverse than synthetic particles like PLGA and silica, which could cause it to interact with the soil differently. While these design rules may apply to Tobacco mild green mosaic virus, the researchers say more work is needed to better understand why other nanoparticles behave the way they do.
“We’re taking concepts we’ve learned from nanomedicine, where we’re developing nanoparticles for targeted drug delivery, and applying them to agriculture,” Steinmetz said. “In the medical setting, we also see that nanocarriers with skinny, tubular shapes and diverse surface chemistries can navigate the body better. It makes sense that a plant virus can more easily penetrate and move through the soil—probably because that’s where it naturally resides.”
In terms of safety, Tobacco mild green mosaic virus can infect plants of the Solanaceae (or nightshade) family like tomatoes, potatoes and eggplants, but is benign to thousands of other plant species. Also, the virus is only transmitted by mechanical contact between two plants, not through the air. That means if one field is being treated with this virus, nearby fields would not be at risk for contamination, researchers said.
Modeling Pesticide Delivery
The team also developed a computational model that can be used to predict how different pesticide nanocarriers behave in the soil—how deep they can travel; how much of them need to be applied to the soil; and how long they will take to release their load of pesticide.
“Researchers working with a different plant virus or nanomaterial could use our model to determine how well their particle would work as a pesticide delivery agent,” said first author Paul Chariou, a bioengineering PhD student in Steinmetz’s lab at UC San Diego.
“It also cuts down on experimental workload,” Chariou said. Testing just one nanoparticle for this study involves running hundreds of assays, collecting all the fractions from each column and analyzing them. “This all takes at least one month. But with the model, it only took us about 10 soil columns and 4 days to test a new nanoparticle,” he said.
As a next step, Steinmetz and her team are testing Tobacco mild green mosaic virus nanoparticles with pesticide loads. The goal is to test them in the field in the near future.
Learn more: How Plant Viruses Can Be Used to Ward Off Pests and Keep Plants Healthy
The Latest on: Plant viruses
[google_news title=”” keyword=”plant viruses” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Plant viruses
- Dangerous plant fungus infects man in first-known global case, doctors sayon March 30, 2023 at 3:19 pm
Doctors diagnosed the 61-year-old man with a throat abscess caused by the same thing responsible for silver leaf disease in plants, according to a study.
- New Research: A Healthy Plant-Based Diet Lowers Risk of Cancer, Premature Death, and More (Exclusive)on March 30, 2023 at 9:54 am
A healthy plant-based diet can help prevent cancer, cardiovascular disease, and early mortality, according to new research.
- The importance of medicinal plants to treat and manage childhood diseases in the North West Province, South Africaon March 30, 2023 at 5:01 am
Researchers conducted an ethnobotanical survey in the North West Province of South Africa between April and August 2021 among 101 participants using semi-structured face-to-face interviews to gather ...
- Global Agrochemicals Market Report 2023: Impact of Abiotic Stressors and Growing Cases of Plant Diseases Fuels Growthon March 30, 2023 at 3:49 am
Global Agrochemical Market Global Agrochemical Market Dublin, March 30, 2023 (GLOBE NEWSWIRE) -- The "Global Agrochemicals Market by Type (Fertilizers, Pesticides), Crop Type (Cereals & Grains, ...
- Does plant-based diet provide sufficient nutrients?on March 30, 2023 at 12:05 am
A well-structured plant-based diet is reported to be beneficial to people from all walks of life and help in reducing the chances of needing.healthcare. health. meal. diet. nutrition. nutrients.
- Daily Intake of Plant Food Sources can Keep Chronic Diseases at Bayon March 29, 2023 at 1:21 pm
Adding plant food sources to your diet and avoiding too much alcohol, salt, or sodium consumption can save you from chronic diseases.
- Opening The Door To The Use Of Antibodies To Protect Plants From Pathogenson March 29, 2023 at 10:03 am
New technologies are currently being explored to protect our agriculturally important plants from invading pathogens.
- Man infected with deadly plant fungus in world-first caseon March 29, 2023 at 6:49 am
A man in India caught a plant fungal disease in a world-first case of human infection. Medics at the Consultant Apollo Multispecialty Hospitals in India wrote in the journal Medical Mycology Case ...
- A plant-based compound that inhibits reactivation of the HIV viral reservoir, giving the immune system a breakon March 28, 2023 at 11:21 am
As of 2022, approximately 1.2 million people in the United States are living with HIV. Antiretroviral therapies have enabled many of these individuals to live productive, symptom-free lives, but a ...
- Researcher Calls 1st Marburg Virus Outbreak A ‘Lab Leak,’ Here’s Why Experts Pushed Backon March 27, 2023 at 1:54 pm
A researcher tweeted what he called a “fun fact” about the Marburg Virus that’s currently spreading and threatening lives in Tanzania and Equatorial Guinea.
via Bing News