The Scripps Research Institute (TSRI)

The Scripps Research Institute (TSRI) is a nonprofit American medical research facility that focuses on research and education in the biomedical sciences.

Can fitness trackers and smartwatches predict COVID-19 infection?

A potential new strategy for treating eye diseases that affect millions of people

Asymptomatic Covid-19 infections are a big deal: They are up to 45 percent of SARS-CoV-2 infections

A special molecular switch could be embedded into gene therapies to allow doctors to control dosing

Scientists at Scripps Research in Jupiter have developed a special molecular switch that could be embedded into gene therapies to allow doctors to control dosing. The feat, reported in the scientific journal Nature Biotechnology, offers gene therapy designers what may be the first viable technique for adjusting the activity levels of their therapeutic genes. The lack of

A special molecular switch could be embedded into gene therapies to allow doctors to control dosing

Can these experimental drugs reverse broader aging in humans as they appear to have done in mice?

Salk researchers show how two experimental Alzheimer’s drugs protect the brains of mice from other aspects of aging In mouse models of Alzheimer’s disease, the investigational drug candidates known as CMS121 and J147 improve memory and slow the degeneration of brain cells. Now, Salk researchers have shown how these compounds can also slow aging in

Can these experimental drugs reverse broader aging in humans as they appear to have done in mice?

Remodeling gut microbiomes to fight disease

You are what you eat — right down to the microbiome living in your gut. Diet can affect which microbes are in the intestinal tract, and research has shown that harmful gut microbiome changes can lead to illnesses such as heart disease, obesity and cancer. Today, scientists will report the development of molecules that can

Remodeling gut microbiomes to fight disease

A vaccine for fentanyl addiction?

A vaccine that combines a fentanyl antigen with a tetanus toxoid has been shown to reduce fentanyl choices and increase food choices with effects lasting several months in rats. These results suggest that the vaccine may not only decrease dangerous drug-taking behavior, but can also increase behaviors maintained by healthier non-drug alternatives. The findings are

A vaccine for fentanyl addiction?

A blood test for PTSD?

A cutting-edge blood test discovered by Indiana University School of Medicine researchers could help more accurately diagnose military veterans and other people experiencing post-traumatic stress disorder, and potentially provide more precise treatments and prevention. A study led by psychiatry professor Alexander Niculescu, MD, PhD, and published this week in the high-impact SpringerNature journal Molecular Psychiatry, tracked more than 250 veterans

A blood test for PTSD?

Could an antibiotic protect against neurodegenerative diseases during aging?

The antibiotic minocycline increases the lifespan of aged roundworms and prevents the buildup of proteins, revealing a protective mechanism that could be exploited therapeutically to help prevent neurodegenerative diseases. Now, scientists at Scripps Research have found that minocycline can increase the lifespan of roundworms by preventing the buildup of proteins during aging, according to a

Could an antibiotic protect against neurodegenerative diseases during aging?

Could a vaccine help the opioid epidemic?

Synthetic psychoactive drugs have become a serious public health threat in recent years. This is particularly true of the fentanyls, a large family of synthetic opioids, which can be up to 10,000 times more potent than morphine. Synthetic opioids are highly addictive and, because of their potency, often prove fatal: among the roughly 72,000 drug

Could a vaccine help the opioid epidemic?

How to neutralize the many types of Ebola and other closely related pathogens using rare antibodies

Two new studies by scientists at Scripps Research are bringing Ebola virus’s weaknesses into the spotlight, showing for the first time exactly how human and mouse antibodies can bind to the virus and stop infection—not only for Ebola virus, but for other closely related pathogens as well. The research suggests antibodies like these could be

How to neutralize the many types of Ebola and other closely related pathogens using rare antibodies

An inexpensive urine dipstick test detects the cause of a disease that blinds millions

Scientists at Scripps Research have developed a urine diagnostic to detect the parasitic worms that cause river blindness, also called onchocerciasis, a tropical disease that afflicts 18 to 120 million people worldwide. Described in the journal ACS Infectious Diseases, the new, non-invasive test may provide an inexpensive method of determining in real time whether a person

An inexpensive urine dipstick test detects the cause of a disease that blinds millions

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At the forefront of science and innovation
on February 18, 2021 at 6:34 am
Jia Xie, an assistant professor in the Chemistry Department, is the first junior professorship hire for the Frost Institute of Chemistry and Molecular Science (FICMS), now under construction. Xie, who ...
Sickness lasts longer with UK variant, study suggests
on February 17, 2021 at 4:02 pm
“We thought [the UK variant’s] increased infectiousness was due to higher viral load,” Eric Topol, director of the Scripps Research Translational Institute, said. The new data, he ...
Scripps Research Receives Gift Toward Science Education
on February 17, 2021 at 8:00 am
The William R. Kenan, Jr. Charitable Trust will support the institute's internship and education programs with a $1.8 million donation.
Scripps Research collaborates with Tempus to develop a predictive model of glucose responses
on February 3, 2021 at 4:00 pm
Scripps Research, a globally recognized nonprofit biomedical research institute, today announced a collaborative research program with Tempus, a leader in precision medicine and artificial ...
First-in-human clinical trial confirms HIV vaccine approach by IAVI and Scripps Research
on February 3, 2021 at 12:30 pm
Read more at iavi.org. Scripps Research is a private, nonprofit biomedical institute ranked the most influential in the world for its impact on innovation. With campuses in La Jolla, California ...

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Scripps Research Institute (The), CA -- Moody's assigns A1 to The Scripps Research Institute's (CA) revenue bonds; outlook stable - Yahoo Finance
February 23, 2021
Scripps Research Institute Forced to Pay $10M For Misusing Funds from NIH Research Grants - Whistleblower News Review
October 7, 2020
Scripps Research Institute to Pay $10M for Improper Use of NIH Grants - Times of San Diego
September 11, 2020
The Scripps Research Institute to Pay $10 Million to Settle False Claims Act Allegations Related to Mischarging NIH-Sponsored Research Grants - The Southern Maryland Chronicle
September 13, 2020
Scripps Pays to Settle NIH Grant Allegations - The National Law Review
September 23, 2020

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Salk team reveals never-before-seen antibody binding, informing both liver cancer and antibody design
on February 20, 2021 at 8:00 am
That’s precisely how a multi-institutional research team led by Salk scientists defined how antibodies can recognize a compound called phosphohistidine — a highly unstable molecule that has been found ...
Scientists discover new target to treat major depressive disorder
on February 19, 2021 at 10:41 am
Researchers at The Scripps Research Institute (TSRI) have discovered a new target for treating major depressive disorder. The research shows that individuals with high levels of an enigmatic ...
Experts warn against COVID-19 variants as states reopen
on February 18, 2021 at 2:22 pm
States are beginning to ease coronavirus restrictions, but health experts say we don’t know enough yet about variants to roll back measures that could help slow their spread. As more people ...
At the forefront of science and innovation
on February 18, 2021 at 6:34 am
Jia Xie, an assistant professor in the Chemistry Department, is the first junior professorship hire for the Frost Institute of Chemistry and Molecular Science (FICMS), now under construction. Xie, who ...
Salk team reveals never-before-seen antibody binding, informing liver cancer, antibody design
on February 17, 2021 at 2:07 pm
Previously, Hunter showed that phosphorylation on the amino acid tyrosine can drive cancer progression, a discovery that ... Biology at the Scripps Research Institute and a world-renowned expert ...

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The Scripps Research Institute (TSRI) Discovery

Scripps Research Institute (The), CA -- Moody's assigns A1 to The Scripps Research Institute's (CA) revenue bonds; outlook stable - Yahoo Finance
February 23, 2021
Scripps Research Institute to Pay $10M for Improper Use of NIH Grants - Times of San Diego
September 11, 2020
Scripps Pays to Settle NIH Grant Allegations - The National Law Review
September 23, 2020
Discovery led by Scripps Research scientists can make better genetic drugs - The San Diego Union-Tribune
August 2, 2018
The Scripps Research Institute Signs Collaboration Agreement with Pfizer to Advance DNA-Encoded Library Technology - PR Newswire
January 10, 2017

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The Scripps Research Institute (TSRI)

The Scripps Research Institute (TSRI) is a nonprofit American medical research facility that focuses on research and education in the biomedical sciences.

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