Howard Hughes Medical Institute (HHMI)

The Howard Hughes Medical Institute (HHMI) is a United States non-profit medical research organization based in Chevy Chase, Maryland.

Testing a drug that may halt an overactive immune response before it ramps up

A multicancer blood test could be a game changer for early diagnosis

A new way to breach brain barriers to attack tumors

Using genetically engineered bacteriophages to fight infection: Viruses that can infect and kill bacteria

Scientists have used an experimental therapy that relies on bacteria-infecting viruses collected, in part, through HHMI’s SEA-PHAGES program to fight a Mycobacterium infection in a 15-year-old girl. The patient, a 15-year-old girl, had come to London’s Great Ormond Street Hospital for a double lung transplant. It was the summer of 2017, and her lungs were struggling to

Using genetically engineered bacteriophages to fight infection: Viruses that can infect and kill bacteria

New hope for neurodegenerative brain disorders

DGIST’s research Team has clarified the fundamentals of coiled toxin protein which causes neurodegenerative brain disorders A research team led by Professor Sung Bae Lee of Brain and Cognitive Sciences and Professor Daehee Hwang of New Biology (Vice-head of the Plant Age and Life Research Group, IBS) has identified the early neuropathology mechanism of structural

New hope for neurodegenerative brain disorders

Using genomics and gene editing rapidly bring groundcherries toward domestication

By combining genomics and gene editing, researchers have figured out how to rapidly bring a plant known as the groundcherry toward domestication. Strawberries, blueberries, blackberries, raspberries, and… groundcherries? A little-known fruit about the size of a marble could become agriculture’s next big berry crop. To prepare the groundcherry (Physalis pruinosa) for mainstream farming, Howard Hughes Medical Institute

Using genomics and gene editing rapidly bring groundcherries toward domestication

Easy-to-use technology that simultaneously monitors neural activity at hundreds of different sites within the brain

Neuropixels probes represent a significant advance in measurement technology and will allow for the most precise understanding yet of how large networks of nerve cells coordinate to give rise to behavior and cognition. Neuroscientists who want to follow the nervous system’s cellular conversations will soon have access to easy-to-use technology that simultaneously monitors neural activity

Easy-to-use technology that simultaneously monitors neural activity at hundreds of different sites within the brain

A process that could one day enable precise DNA surgery to correct mutations that cause human diseases

A new type of DNA editing enzyme, developed in HHMI Investigator David Liu’s lab, lets scientists directly and permanently change single base pairs of DNA from A•T to G•C. The process could one day enable precise DNA surgery to correct mutations that cause human diseases. DNA editing just got a sharp, new pencil. Researchers have

A process that could one day enable precise DNA surgery to correct mutations that cause human diseases

AI saves 3,800 years work building the most comprehensive neural maps of behavior yet created (fly)

Scientists at HHMI’s Janelia Research Campus created comprehensive brain maps linking different groups of neurons to specific behaviors, using a machine-learning program that annotated more than 225 days of videos of flies – a feat that would have taken humans some 3,800 years. A smart computer program named JAABA has helped scientists create a brain-wide

AI saves 3,800 years work building the most comprehensive neural maps of behavior yet created (fly)

IsoView Microscope helps scientists see the big picture

High-speed microscope images entire living organisms at high resolution A new microscope developed at the Howard Hughes Medical Institute’s Janelia Research Campus is giving scientists a clearer, more comprehensive view of biological processes as they unfold in living animals. The microscope produces images of entire organisms, such as a zebrafish or fruit fly embryo, with

IsoView Microscope helps scientists see the big picture

Another Milestone in Hybrid Artificial Photosynthesis

Berkeley Lab Researchers Use Solar Energy and Renewable Hydrogen to Produce Methane A team of researchers at the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) developing a bioinorganic hybrid approach to artificial photosynthesis have achieved another milestone. Having generated quite a buzz with their hybrid system of semiconducting nanowires and bacteria

Another Milestone in Hybrid Artificial Photosynthesis

NTU scientists discover new treatment for dementia

Pushing new frontiers in dementia research, Nanyang Technological University, Singapore (NTU Singapore) scientists have found a new way to treat dementia by sending electrical impulses to specific areas of the brain to enhance the growth of new brain cells. Known as deep brain stimulation, it is a therapeutic procedure that is already used in some

NTU scientists discover new treatment for dementia

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Howard Hughes Medical Institute (HHMI) Research

Celebrating a decade of neurological research of the Jan and Dan Duncan Neurological Research Institute
on January 11, 2021 at 1:19 pm
At the end of 2020, the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children’s Hospital and Baylor College of Medicine ...
Myeloid Therapeutics Launches with Over $50 Million in Financing and Two Clinical Trials
on January 6, 2021 at 4:13 am
and executive director of the Howard Hughes Medical Institute (HHMI) Janelia Research campus; and hematologist, oncologist and Pulitzer-Prize winning author Siddhartha Mukherjee, M.D., D.Phil.
Myeloid Therapeutics Launches with Over $50 Million in Financing and Two Clinical Trials
on January 6, 2021 at 3:12 am
The Company's scientific founders include Ronald Vale, Ph.D., a world-renowned biochemist and cell biologist, and executive director of the Howard Hughes Medical Institute (HHMI) Janelia Research ...
David Julius Elected as HHMI Trustee
on December 21, 2020 at 7:00 am
David Julius, PhD, a professor at the University of California, San Francisco (UCSF), has been elected a Trustee of the Howard Hughes Medical Institute (HHMI), the largest private biomedical research ...
What is HHMI?
on May 16, 2020 at 5:16 am
One of the world's largest philanthropies, HHMI is a nonprofit medical research organization that employs hundreds of leading biomedical scientists working at the forefront of their fields. The ...

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Howard Hughes Medical Institute (HHMI) Research

SARS-CoV-2 Needs Cholesterol to Invade Cells and Form Mega Cells - Howard Hughes Medical Institute
January 21, 2021
Laboratory Manager - Zamore Lab - Nature.com
December 26, 2020
HHMI Announces Open Access Publishing Policy | HHMI.org - Howard Hughes Medical Institute
October 1, 2020
HHMI Opens New Program for Medically Trained Scientists - Howard Hughes Medical Institute
March 11, 2020
David Julius Elected as HHMI Trustee | HHMI.org - Howard Hughes Medical Institute
December 21, 2020

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Howard Hughes Medical Institute (HHMI) Discovery

Using CRISPR Genetic Technology to Catch Cancer in the Act
on January 24, 2021 at 10:24 am
Using CRISPR technology, researchers are tracking the lineage of individual cancer cells as they proliferate and metastasize in real-time. When cancer is confined to one spot in the body, doctors can ...
SARS-CoV-2 needs cholesterol to invade cells and form mega cells
on January 22, 2021 at 5:34 am
Cholesterol, the waxy compound better known for clogging arteries, helps the virus open cells up and slip inside, Howard Hughes Medical Institute ... This discovery of cholesterol's importance ...
Four MIT scientists honored with 2021 National Academy of Sciences awards
on January 21, 2021 at 2:08 pm
Herrero, Aviv Regev, Susan Solomon, and Feng Zhang are among the 20 recipients of 2021 National Academy of Sciences awards.
SARS-CoV-2 Needs Cholesterol to Invade Cells and Form Mega Cells
on January 21, 2021 at 8:07 am
People taking cholesterol-lowering drugs may fare better than others if they catch the novel coronavirus. A new study hints at why: the virus relies on the fatty molecule to get past the cell’s ...
Celebrating a decade of neurological research of the Jan and Dan Duncan Neurological Research Institute
on January 11, 2021 at 1:19 pm
At the end of 2020, the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children’s Hospital and Baylor College of Medicine ...