Rice bioengineers lead effort to print scaffolds to heal bone and cartilage
Bioscientists are moving closer to 3D-printed artificial tissues to help heal bone and cartilage typically damaged in sports-related injuries to knees, ankles and elbows.
Scientists at Rice University and the University of Maryland reported their first success at engineering scaffolds that replicate the physical characteristics of osteochondral tissue – basically, hard bone beneath a compressible layer of cartilage that appears as the smooth surface on the ends of long bones.
Injuries to these bones, from small cracks to pieces that break off, can be painful and often stop athletes’ careers in their tracks. Osteochondral injuries can also lead to disabling arthritis.
The gradient nature of cartilage-into-bone and its porosity have made it difficult to reproduce in the lab, but Rice scientists led by bioengineer Antonios Mikos and graduate student Sean Bittner have used 3D printing to fabricate what they believe will eventually be a suitable material for implantation.
Their results are reported in Acta Biomaterialia.
“Athletes are disproportionately affected by these injuries, but they can affect everybody,” said Bittner, a third-year bioengineering graduate student at Rice, a National Science Foundation fellow and lead author of the paper. “I think this will be a powerful tool to help people with common sports injuries.”
The key is mimicking tissue that turns gradually from cartilage (chondral tissue) at the surface to bone (osteo) underneath. The Biomaterials Lab at Rice printed a scaffold with custom mixtures of a polymer for the former and a ceramic for the latter with imbedded pores that would allow the patient’s own cells and blood vessels to infiltrate the implant, eventually allowing it to become part of the natural bone and cartilage.
“For the most part, the composition will be the same from patient to patient,” Bittner said. “There’s porosity included so vasculature can grow in from the native bone. We don’t have to fabricate the blood vessels ourselves.”
The future of the project will involve figuring out how to print an osteochondral implant that perfectly fits the patient and allows the porous implant to grow into and knit with the bone and cartilage.
Mikos said the collaboration is a great early success for the Center for Engineering Complex Tissues (CECT), a National Institutes of Health center at Maryland, Rice and the Wake Forest School of Medicine developing bioprinting tools to address basic scientific questions and translate new knowledge into clinical practice.
“In that context, what we’ve done here is impactful and may lead to new regenerative medicine solutions,” Mikos said.
Learn more: 3D-printed tissues may keep athletes in action
The Latest on: 3D-printed artificial tissues
via Google News
The Latest on: 3D-printed artificial tissues
- Tissue Engineered Skin Substitute Market is estimated for a robust 9.6% CAGR during 2022 – 2029on August 5, 2022 at 5:26 am
Pages Report] Rapid expansion of wound management space has argued well for the growth in demand for tissue engineered skin substitutes. The global tissue engineered skin substitute market is ...
- The Download: experimental embryos and the US monkeypox emergencyon August 5, 2022 at 5:10 am
Earlier this week, Hanna showed that starting with mouse stem cells, his lab could form highly realistic-looking mouse embryos and keep them growing in a mechanical womb for several days until they ...
- This startup wants to copy you into an embryo for organ harvestingon August 4, 2022 at 11:01 am
With plans to create realistic synthetic embryos, grown in jars, Renewal Bio is on a journey to the horizon of science and ethics.
- Can Smart Implants Monitor Healing Inside the Body?on August 1, 2022 at 5:00 pm
Image courtesy of iSMaRT Lab at the University of Pittsburgh Using artificial implants in surgeries to support ... That’s the promise of new custom, 3D-printed smart metamaterial implants developed by ...
- 3D model of brain tumor environment could aid personalized treatmenton July 31, 2022 at 5:01 pm
But now Virginia Tech scientists have developed a novel 3D tissue-engineered model of the glioblastoma tumor microenvironment that can be used to learn why the tumors return and what treatments ...
- 3D Bioprinting for Tissue and Organ Regeneration Market worth $424.3 Million by 2030 - Exclusive Report by InsightAce Analyticon July 29, 2022 at 11:47 pm
This technique has been a pioneer in making artificial multicellular tissues/organs due to its capacity to generate regenerative tissues and organs. 3D printing is a promising method for ...
- 3D Bioprinting Market worth $3.3 billion by 2027 – Exclusive Report by MarketsandMarkets™on July 25, 2022 at 8:06 am
It also enables the printing of prosthetic limbs, which can be replaced in patients with missing limbs. Moreover, the 3D bioprinting process enables the faster development of organs and tissues as ...
- 3D Bioprinting Market worth $3.3 billion by 2027 – Exclusive Report by MarketsandMarkets™on July 25, 2022 at 7:09 am
D Bioprinting Market is projected to USD 3.3 billion by 2027 from USD 1.3 billion in 2022, at a CAGR of 20.8% between 2022 and 2027, according to a new report by MarketsandMarkets™. Factors such as ...
- Study: Making an artificial heart fit for a human — with focused rotary jet spinning, not 3Don July 7, 2022 at 11:01 am
The researchers compare their methods to two other ways of producing artificial organs and tissue: 3D printing and fiber spinning. Although 3D printing continues to contribute major advancements ...
- 3D-Printed Tissues Could Help Heal Serious Sports Injurieson July 6, 2022 at 5:00 pm
3D bioprinting already has come a long way, with researchers across the globe successfully printing live human tissue and complex circulatory systems for creating artificial skin and even organs. Now ...
via Bing News