Tumult in the bacterial community that occupies your gut—known as your microbiome—doesn’t just cause indigestion. For people recovering from a stroke, it may influence how they get better.
A recent study by Allison Brichacek and Candice Brown, researchers in the West Virginia University School of Medicine, suggests that stroke patients’ microbiomes—and even the structure of their guts—may still be out of kilter a month after the stroke has passed.
“We’re interested in the gut-brain axis—how the gut influences the brain and vice versa,” said Brichacek, a doctoral student in the immunology and microbial pathogenesis graduate program. She presented her findings at the International Stroke Conference in February.
Previous studies indicated the immediate effects a stroke can have on someone’s microbiome, but they didn’t explore whether these effects lingered. To find out, Brichacek, Brown and their colleagues—including Sophia Kenney, an undergraduate majoring in immunology and medical microbiology, and Stan Benkovic, a researcher in Brown’s lab—induced a stroke in animal models. Other models—the control group—didn’t have a stroke. The researchers compared the two groups’ microbiomes three days, 14 days and 28 days post-stroke. They also scrutinized their intestines for microscopic disparities.
Bacterial friend or foe?
One of the researchers’ discoveries was that a certain family of bacteria— Bifidobacteriaceae—was less prominent in post-stroke models than in healthy ones both 14 and 28 days out. If the name of the family sounds familiar, that’s probably because Bifidobacterium—a genus within theBifidobacteriaceae family—is a common ingredient in yogurt and probiotics. These bacteria are known for supporting digestive health and may be associated with better outcomes in stroke patients.
That may sound like bad news for people who have had a stroke, but the loss of Bifidobacteriaceae bacteria isn’t the only long-term change their microbiomes undergo. Another family associated with worse outcomes—Helicobacteraceae—was also more common in post-stroke models 28 days out. The practical implications of these microbiotic shifts are still unknown.
The team also found that the ratio of one type of bacteria—Firmicutes—to another—Bacteriodetes—was higher in post-stroke models. After 14 days, the ratio in the experimental group was almost six times higher than in the control group. After 28 days, the experimental group’s ratio had fallen, but it was still more than triple that of the control group. Having a high Firmicutes-to-Bacteriodetes ratio can be concerning because of its link to obesity, diabetes and inflammation.
The gut-brain axis seems to distribute a stroke’s effects in another way, too. The research team discovered that a stroke can cause intestinal abnormalities. Under magnification, the intestinal tissues of healthy models resembled an orderly colony of coral. The branches of “coral” were actually villi—tiny projections that increase the surface area of the intestinal wall and multiply the amount of nutrients it can absorb.
But in post-stroke models, the intestinal tissue looked scrambled, even a month after researchers triggered the stroke. “There’s disorganization here,” Brichacek said. “There’s also less space between the villi to allow nutrients to move around.” Poor circulation of nutrients can lead to compromised stroke recovery.
Treating the brain by treating the gut
What does all of this mean for stroke recovery? “Big picture: seeing a persistent, chronic change 28 days after stroke that is associated with this increase in some of the negative bacteria means that this could have negative effects on brain function and behavior. Ultimately, this could slow or prevent post-stroke recovery,” said Brown, an assistant professor in Department of Neuroscience and faculty member in the Rockefeller Neuroscience Institute.
Her and Brichacek’s findings may point to new therapeutic options for stroke. “If it ends up being that the gut has an influence on the repair of the brain, maybe our stroke treatments shouldn’t just be focused on what we can do for the brain. Maybe we need to think about what can we do for the gut,” Brichacek said.
For example, some bacteria in the gut produce short-chain fatty acids that affect brain function. “Some of these short-chain fatty acids are good, and some are bad,” said Brown. “If the bacteria that produce some of the bad short-chain fatty acids are proliferating, that could have a negative outcome for brain function.” Could nudging a stroke patient’s microbiome in a healthier direction—using probiotic supplements or prebiotic foods, for instance—help prevent emotional or cognitive decline?
Likewise, might it be possible to lower a stroke patient’s Firmicutes-to-Bacteriodetes ratio and promote weight loss, decrease diabetes risk and make subsequent strokes less likely?
The researchers’ next step is to study intestinal changes in more depth. Just as the blood-brain barrier isolates the brain from the blood circulating elsewhere in the body, a barrier seals off the intestine from its surroundings. Brown and Brichacek want to know how a breach in the intestinal barrier could affect the central nervous system. Protecting this barrier is critical for the function of the enteric nervous system—a part of the peripheral nervous system that includes the gut and often is called our “second brain” or “little brain.”
“People don’t appreciate the gut. It controls much more than digestion,” Brown said. “Our results suggest that stroke targets both brains—the brain in our head and the brain in our gut.”
The Latest on: Microbiome
via Google News
The Latest on: Microbiome
- Fungal microbiome: Whether mice get fatter or thinner depends on the fungi that live in their guton March 5, 2021 at 2:17 am
Fungi make up a small but important part of gut microbiomes. Mogana Das Murtey and Patchamuthu Ramasamy via Wikimedia Commons, CC BY-SAThe Research Brief is a short take about interesting academic ...
- Why You Need to Start Paying Attention to Your Skin Microbiome—Especially Nowon March 4, 2021 at 3:15 pm
"Our skin microbiome refers to the trillions of microscopic organisms, mostly bacteria, that live on and in our skin’s various layers," explains Bowe. "A healthy or 'balanced' skin microbiome is like ...
- Alterations in skin microbiome mediated by radiotherapy and their potential roles in the prognosis of radiotherapy-induced dermatitis: a pilot studyon March 4, 2021 at 2:40 pm
Radiotherapy-induced dermatitis (RID) is an inflammatory cutaneous disorder that is acquired as an adverse effect of undergoing radiotherapy. Skin microbiome dysbiosis has been linked to the outcomes ...
- Vaping Changes Your Oral Microbiome, Which May Have Effects Beyond The Mouthon March 4, 2021 at 7:51 am
Vaping might throw off the oral microbiome's delicate balance, leading to health concerns for the mouth and the rest of the body.
- Novel host-viral-microbiome interactions during COVID-19 may determine outcomeon March 3, 2021 at 8:57 pm
A new preprint on the medRxiv* server discusses how the underlying disease mechanisms are regulated such that the local or mucosal immune response is distinct from the systemic response.
- Human Microbiome Market to witness high growth in near future to 2026on March 3, 2021 at 9:34 am
This study elucidates how the Human Microbiome market will perform over the forecast timeline. Growth indicators as well as the growth rate of the industry during the study period has been expounded ...
- Oralcare is the new self-care: why you need to start caring for the microbiome in your mouthon March 3, 2021 at 4:34 am
You know all about caring for your gut microbiome, perhaps you’ve even invested in a probiotic face cream or serum to protect your skin microbiome, but when was the last time you spared a thought for ...
- Modere Axis™ TreBiotic with Microbiome Matrix™ Advances New Frontier in Wellnesson March 2, 2021 at 5:57 am
Modere, a worldwide, live-clean essential lifestyle brand of supplements, household, and personal care products, today announced the launch of the company's next generation supplement for gut health, ...
- New studies explore how gut microbiome affects Alzheimer’s and diabeteson March 1, 2021 at 7:23 pm
Two new studies are offering yet more evidence the gut microbiome is deeply intertwined with our metabolic and brain health. One study offers some of the first experimental evidence to show a direct ...
- Scientists can predict how long you'll live from your gut microbiomeon March 1, 2021 at 11:00 am
US researchers have identified distinct signatures in the gut microbiome that are associated with either healthy or unhealthy ageing trajectories.
via Bing News