In what is believed to be a world first, Griffith University researchers have cured cervical cancer in mice using CRISPR gene-editing technology.
“This is the first cure for any cancer using this technology,’’ said lead researcher Professor Nigel McMillan from Menzies Health Institute Queensland.
The scientists used CRISPR-Cas9 to successfully target and treat cervical cancer tumours in vivo (via injection into live and tumour-bearing mice) using “stealth” nanoparticles.
“The nanoparticles search out the cancer-causing gene in cancer cells and “edit it’’ by introducing some extra DNA that causes the gene to be misread and stop being made,’’ Professor McMillan said.
“This is like adding a few extra letters into a word, so the spell checker doesn’t recognise it “anyTTmore’’. Because the cancer must have this gene to produce, once edited the cancer dies.
“In our study, the treated mice have 100% survival and no tumours. The mice showed no other clinical signs such as inflammation from treatment but there may be other gene changes we haven’t measured yet.
“Other cancers can be treated once we know the right genes.”
Nearly all cervical cancers are caused by a human papillomavirus infection (HPV), with more than 250* women in Australia dying from the disease each year. *source: Cancer Australia
“Persistent infection with high-risk HPV is responsible for 99.7% of cervical cancer cases,’’ Professor McMillan said.
“After infection, the HPV integrates the E6 and E7 oncogene (genes with the potential to cause cancer), into the human genome which drive and sustain cervical cancer.”
The Griffith University scientists are working towards human trials of the gene therapy in the next five years.
The Latest on: Cervical cancer
via Google News
The Latest on: Cervical cancer
- After cervical cancer, Miracle Mom was willing to die to have a baby — and she almost didon May 6, 2021 at 4:01 am
Rony Wu Bush went through a miscarriage, failed fertility treatments, a tough pregnancy, a premature birth and a hysterectomy that nearly killed her ...
- Experts want home tests for cervical cancer brought in immediately after 50,000 smears missed over lockdownon May 5, 2021 at 10:00 am
As many as 50,000 cervical smears were missed during lockdown, but experts say cervical cancer could be eliminated with better vaccination and screening rates.
- Snail/PRMT5/NuRD complex contributes to DNA hypermethylation in cervical cancer by TET1 inhibitionon May 5, 2021 at 9:28 am
The biological function of PRMT5 remains poorly understood in cervical cancer metastasis. Here, we report that PRMT5 physically associates with the transcription factor Snail and the NuRD (MTA1) ...
- Cervical Cancer In India: Best Practices For Prevention And Early Detectionon May 5, 2021 at 4:23 am
Women over age 30 are at higher risk for cervical cancer. Read on to know the best measures to avert cervical cancer as well as self-care for cervical cancer.
- Dalrada Health Presents VIA Cervical Cancer Screening Study Findings at 17th World Congress for Cervical Pathology and Colposcopyon May 4, 2021 at 9:26 am
Dalrada Corporation (OTCQB: DFCO, “Dalrada”) is pleased to announce to its shareholders and the public that Dalrada Health’s abstract on the topic ...
- Cervical Cancer Drugs Global Market Report 2021: COVID 19 Impact and Recovery to 2030on May 4, 2021 at 8:24 am
Reportlinker.com announces the release of the report "Cervical Cancer Drugs Global Market Report 2021: COVID 19 Impact ...
- Kiri Allan says as wahine Māori, she has just 13pc chance of surviving cervical canceron May 3, 2021 at 1:26 pm
As a Māori woman, the Labour MP is four times more likely to die from cervical cancer than Pākehā. "It is wrong," she says.
- Kiri Allan reveals she has 13 pct chance of surviving cervical canceron May 3, 2021 at 1:49 am
Kiri Allan has revealed she has just a 13 percent chance of surviving cervical cancer. The Labour MP was diagnosed with stage 3 cervical cancer in April. She has since used her diagnosis to raise ...
- Universiti Malaya PhD student awarded global public health grant to promote cervical cancer self-care amid Covid-19on April 30, 2021 at 9:03 am
PETALING JAYA, April 30 ― A Universiti Malaya (UM) student from the medicine faculty has been named global ambassador by the Global Network for Academy of Public Health to promote cervical cancer ...
- Alantolactone inhibits cervical cancer progression by downregulating BMI1on April 29, 2021 at 5:33 am
Cervical cancer is the second most common cancer in women. Despite advances in cervical cancer therapy, tumor recurrence and metastasis remain the leading causes of mortality. High expression of BMI1 ...
via Bing News