Many major advances in medicine, especially in neurology, have been sparked by recent advances in electronic systems that can acquire, process, and interact with biological substrates. These bioelectronic systems, which are increasingly used to understand dynamic living organisms and to treat human disease, require devices that can record body signals, process them, detect patterns, and deliver electrical or chemical stimulation to address problems.
In the past, traditional silicon-based transistors have been used in bioelectronic devices, but they must be carefully encapsulated to avoid contact with body fluids—both for the safety of the patient and the proper operation of the device. This requirement makes implants based on these transistors bulky and rigid. In parallel, a good deal of work has been done in the organic electronics field to create inherently flexible transistors out of plastic, including designs such as electrolyte-gated or electrochemical transistors that can modulate their output based on ionic currents. However, these devices cannot operate fast enough to perform the computations required for bioelectronic devices used in neurophysiology applications.Khodagholy and his postdoctoral research fellow George Spyropoulos, the first author of this work, built a transistor channel based on conducting polymers to enable ionic modulation, and, in order to make the device fast, they modified the material to have its own mobile ions. By shortening the distance that ions needed to travel within the polymer structure, they improved the speed of the transistor by an order of magnitude compared to other ionic devices of the same size.
Internal ion-gated organic electrochemical transistor: A Building Block for Intergrated Bioelectronics
“Importantly, we only used completely biocompatible material to create this device. Our secret ingredient is D-sorbitol, or sugar,” says Khodagholy. “Sugar molecules attract water molecules and not only help the transistor channel to stay hydrated, but also help the ions travel more easily and quickly within the channel.”
Because the IGT could significantly improve the ease and tolerability of electroencephalography (EEG) procedures for patients, the researchers selected this platform to demonstrate their device’s translational capacity. Using their transistor to record human brain waves from the surface of the scalp, they showed that the IGT local amplification directly at the device-scalp interface enabled the contact size to be decreased by five orders of magnitude—the entire device easily fits between hair follicles, substantially simplifying placement. The device could also be easily manipulated by hand, improving mechanical and electrical stability. Moreover, because the micro-EEG IGT device conforms to the scalp, no chemical adhesives were needed, so the patient had no skin irritation from adhesives and was more comfortable overall.
These devices could also be used to make implantable closed loop devices, such as those currently used to treat some forms of medically refractory epilepsy. The devices could be smaller and easier to implant, and also provide more information.
“Our original inspiration was to make a conformable transistor for neural implants,” Gelinas notes. “While we specifically tested it for the brain, IGTs can also be used to record heart, muscle, and eye movement.”
Khodagholy and Gelinas are now exploring if there are physical limits to what kind of mobile ions they can embed into the polymer. They are also studying new materials into which they can embed mobile ions as well as refining their work on using the transistors to make integrated circuits for responsive stimulation devices.
“We are very excited that we could substantially improve ionic transistors by adding simple ingredients,” Khodagholy notes. “With such speed and amplification, combined with their ease of microfabrication, these transistors could be applied to many different types of devices. There is great potential for the use of these devices to benefit patient care in the future.”
The Latest on: Bioelectronic devices
via Google News
The Latest on: Bioelectronic devices
- Thermometer News and Researchon July 27, 2022 at 5:00 pm
A team of bioengineers at the UCLA Samueli School of Engineering has invented a novel soft and flexible self-powered bioelectronic device. The best part about returning to the pandemic-besieged ...
- FDA clears Rapid Medical’s small, adjustable thrombectomy deviceon July 27, 2022 at 11:23 am
Rapid Medical announced that it received FDA 510(k) clearance for its Tigertriever 13 device for treating large vessel occlusions.
- Sinus pain is just the beginning for Tivic Health’s CEOon July 25, 2022 at 1:19 pm
Tivic Health CEO Jennifer Ernst thinks the bioelectronic medicine space is ready to explode. The company is starting with its ClearUp device.
- Pressure Ulcers Treatment Market To Surpass Value Of US$ 10 Bn In 2031: TMR Studyon July 21, 2022 at 5:41 am
Wearable Bioelectronic Skin Patches Market : The ... It is estimated to expand at a CAGR of 5.3% from 2021 to 2028. Skin Care Devices Market : The global skincare devices market is expected ...
- New Graphene Electronic Tattoos Kickstart Healthcare Electronics 2.0on July 20, 2022 at 10:22 pm
The devices were then analyzed for their bioelectronic and electronic properties. The primary parameter of interest in the present study was the number of monolayers per tattoo. Since the electronic ...
- Monarch Becomes the 1st FDA-Cleared Device for ADHDon July 20, 2022 at 5:00 pm
The goal of Galvani was to develop a series of tiny bioelectronic devices to treat chronic diseases. electroCore is making a significant play in the migraine treatment market. The Basking Ridge, ...
- Patients to Draw Their Own Biomedical Sensors Using Pencil and Paperon July 13, 2022 at 5:00 pm
Wearable bioelectronic devices that stick to the skin and measure things such as temperature, heart rhythms, and other vitals are typically complex devices that use modern materials to do their job.
- Bioelectronics device aims to reduce pain after surgeryon July 5, 2022 at 12:34 pm
The bioelectronic device, from a Northwestern University-led team, takes the form of a soft, flexible implant and it uses cooling, instead of drugs, to silence pain signals. The device is made up ...
- Jin Woo Choion July 5, 2022 at 8:47 am
At LSU Dr. Choi was director of the BioMEMS and Bioelectronics Laboratory. His research interests include MEMS and BioMEMS, biosensors and bioelectronic devices, microfluidic devices and systems, lab ...
- Cellulite Treatment Market To Witness Lucrative Avenues From Advancements In Energy-Based Deviceson July 5, 2022 at 6:43 am
Commercialization of novel devices for minimally invasive treatments ... to expand at a CAGR of 6.9% from 2022 to 2031. Wearable Bioelectronic Skin Patches Market : The global wearable ...
via Bing News