Researchers from The Johns Hopkins University School of Medicine performed a systematic review and meta-analysis of published data on the effect of electrical stimulation therapies on spinal fusion. They found significant improvement overall in the rates of bone fusion following a course of electrical stimulation in both preclinical (animal) and clinical (human) studies.
Detailed findings of this study can be found in a new article, “The effect of electrical stimulation therapies on spinal fusion: a cross-disciplinary systematic review and meta-analysis of the preclinical and clinical data,” by Ethan Cottrill and colleagues, published today in the Journal of Neurosurgery: Spine.
Background: Each year in the United States approximately 400,000 persons undergo spinal fusion surgery for spinal instability, pain, and/or loss of function. For some of these people, surgery alone does not produce complete spinal fusion. In those cases, adjuvant therapies must be instituted to aid in the process of bone healing.
One of these therapies is electrical stimulation. There are three types of electrical stimulation therapy in use today: direct current stimulation, capacitive coupling stimulation, and inductive coupling stimulation (also known as pulsed electromagnetic field).
Direct current stimulation requires implantation of a stimulation device, which is usually done at the time of spinal fusion surgery. The device is small and is placed under the skin on the patient’s back. Via electrodes, the device delivers a small direct current of electricity to the area where fusion needs to occur. The battery powering the device is good for 6 to 12 months; after that time, it can be removed or remain in place as the patient or physician deems appropriate.
Capacitive and inductive coupling stimulation therapies are noninvasive. With capacitive coupling stimulation, two small electrode pads are placed on the skin over the region of desired bone fusion. These pads produce an electrical field surrounding that region when powered by an external alternating current generator. This device is worn by the patient for 6 to 9 months and operates approximately 24 hours per day. Inductive coupling stimulation involves the use of electromagnetic coils placed on the skin over the site of anticipated bone fusion. Alternating current produces an electromagnetic field to induce bone fusion. This device need only be used for 30 minutes to 2 hours per day until fusion is confirmed.
Each therapy has a particular mechanism of action and carries advantages and disadvantages. These are all described and compared in the paper by Cottrill and colleagues.
Present Study: Application of direct or alternating electrical current has been shown to induce and speed up the process of bone healing following spine fusion surgery. Evidence for this has come from small studies. Cottrill and colleagues set out to pool the data from small studies on the effects of electrical stimulation therapies and to comprehensively assess these effects overall and in specific subgroups.
The authors performed a systematic review of all English-language articles describing the effects of electrical stimulation therapies on spinal bone fusion. Applying specific inclusion criteria, they narrowed the studies down to 17 preclinical and 16 clinical studies. Meta-analyses of data from all of the studies that included a control group were also performed (11 preclinical studies [257 animals] and 13 clinical studies [2,144 patients]).
The authors found, overall, that electrical stimulation was effective at augmenting spinal fusion. They found nearly a fivefold increase in the odds of successful bone fusion in animals and a greater than twofold increase in patients treated with electrical stimulation therapy.
With respect to the various types of stimulation therapy, the authors found that in animals the effects of direct current stimulation on spinal fusion were very beneficial, whereas the effects of inductive coupling stimulation were little different from no electrical stimulation at all. (No preclinical studies involved the use of capacitive coupling stimulation.)
In humans, both direct current stimulation and inductive coupling stimulation were highly effective in aiding spinal fusion. The authors were unable to find a difference in efficacy between these two types of electrical stimulation therapies. Only one study of capacitive coupling stimulation therapy in humans fit the inclusion criteria of the systematic review, and that paper showed no statistically significant difference between fusion rates in patients who received electrical stimulation and those who did not (control group).
In a subgroup analysis of clinical studies, the authors found that the number of spinal levels that were fused and whether instrumentation was used did not change the effectiveness of electrical stimulation devices. They also found that these devices improved the rates of fusion in patient groups prone to have difficulty in achieving total spinal fusion, such as patients with difficult-to-treat spines and smokers.
When asked about the importance of the study, the senior author, Daniel Sciubba, MD, said, “We were surprised by how large an effect these therapies have on spinal fusion. It was also encouraging to see that the preclinical data aligned with the clinical evidence, which supports future translational research efforts in spine surgery. Ultimately, we hope our findings will help to inform patients and providers to enhance outcomes following spinal fusion.”
Learn more: The effectiveness of electrical stimulation in producing spinal fusion
The Latest on: Electrical stimulation therapies
[google_news title=”” keyword=”electrical stimulation therapies” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Electrical stimulation therapies
- Lift Droopy Cheeks With A Non-Surgical ‘Facelift’ That Jessica Simpson Lovedon March 29, 2023 at 6:45 pm
Readers, meet EmFace, a new dermatological treatment that utilizes “high intensity focused electrical stimulation and radio frequency” to rebuild your facial muscle mass, along with collagen in order ...
- Electrical Foot Stimulation: A Potential New Method of Deep Venous Thrombosis Prophylaxison March 28, 2023 at 5:00 pm
High-intensity electrical calf muscle stimulation is painful and can be ... to receive and participate in their rehabilitative therapy in an unencumbered manner. Activities of daily living can ...
- Building A Transcutaneous Electrical Nerve Stimulation Device In A Weekendon March 28, 2023 at 5:00 pm
Transcutaneous electrical nerve stimulation (TENS) is a technique that applies electrical current to nerves and muscles for the relief of pain. Before you ask, yes, some of these devices are FDA ...
- Transcranial Electrical Stimulation With Arduino, Hot Glueon March 27, 2023 at 5:00 pm
One example of this is that despite the positive results from many transcranial electrical stimulation (TCS) studies, the devices used are prohibitively expensive, as are treatment regimens for ...
- Percutaneous Tibial Nerve Stimulation for the Treatment of Overactive Bladderon March 26, 2023 at 5:00 pm
Percutaneous Tibial Nerve Stimulation (PTNS ... or "urination disorders" or "urinary incontinence" AND "electric stimulation therapy" or "transcutaneous electric nerve stimulation" or "tibial ...
- ECT and Other Procedures for Schizophreniaon March 21, 2023 at 5:01 pm
In that case, your doctor may recommend brain stimulation therapy to support or replace medications. This type of therapy tries to either stimulate or ease certain brain activity with electrical ...
- Neuromuscular Electrical Stimulation (NMES/EMS) Devices Market Size, Share, Growth Statistics, Leading Players and Market Forecast 2028on March 16, 2023 at 4:31 am
The Global Neuromuscular Electrical Stimulation (NMES/EMS) Devices Market is poised to value CAGR of over 5.1% during ...
- Deep Brain Stimulation for Schizophreniaon March 13, 2023 at 5:00 pm
If you have schizophrenia and medicine doesn't control your symptoms, deep brain stimulation (DBS) may be an option. It's a new treatment that uses electric pulses to help parts of your brain ...
- Spinal Cord Stimulation Doesn’t Help With Back Painon March 12, 2023 at 4:38 pm
According to a new study, spinal cord stimulation does not provide long-term relief for back pain and may actually cause harm to a patient.
- This market report on Electrical Stimulation Therapy provides broad description of this industry.on March 10, 2023 at 5:51 pm
Mar 10, 2023 (Prime PR Wire via Comtex) -- The "Electrical Stimulation Therapy Market" is segmented into regions, Applications, and Types. The report presents the research and analysis provided ...
via Bing News