Autophagy is an important biological recycling mechanism that is used to maintain homeostasis (balance or equilibrium) within all types of animal tissue. Many studies have attempted to understand the relationship between the reduction of autophagy and progression of aging in animals; however, none have provided a clear explanation, until now.
In 2009, a research team led by Tamotsu Yoshimori at Osaka University identified Rubicon as a protein factor that suppresses autophagy by controlling a specific step in this pathway. This time, the team found that Rubicon expression levels increased in an age-related manner in worm, fly, and mouse tissues, publishing their findings in Nature Communications.
Autophagy allows degradation of damaged cellular components and helps to avoid the onset of a variety of diseases related to cellular stress and dysfunction, including cancer, neurodegenerative diseases, and metabolic syndromes. Reduced autophagy has recently been linked to progression of aging in animals. While a variety of methods can increase autophagy in aged animals, thereby slowing the aging process, there has been no definite finding regarding the underlying cause of naturally reduced autophagy.
“Rubicon has been linked to inhibition of the autophagic process, and knockout of Rubicon in mice helped to mitigate autophagy-related liver diseases,” says Yoshimori. “Therefore, we suspected that Rubicon may directly affect aging through its interaction with autophagy.”
In the study, increased levels of Rubicon were found in tissues from multiple aged model organisms (worms, flies, and mice). When the researchers suppressed Rubicon expression, all model organisms demonstrated increased autophagy activity, which led to improvement of multiple age-related factors and slightly increased lifespan in worms and flies.
“Our analyses revealed that Rubicon suppression in model organisms led to reduction of age-associated motor decline, as well as reduction of fibrosis,” says Shuhei Nakamura, lead author on the study. “Importantly, we found that Rubicon suppression enabled aged mice to resist attempts to induce Parkinson’s disease.”
The findings in this study suggest that, because elevated levels of Rubicon lead to reduced autophagy in aged animals, suppression of Rubicon may be critical in extending healthy lifespan in humans.
The Latest on: Aging
via Google News
The Latest on: Aging
- Aging Rivers doesn't fit Pats' needs at QBon January 19, 2021 at 1:53 pm
In 16 games, Rivers completed 369-of-543 passes (68%) for 4,169 yards with 24 passing touchdowns and 11 interceptions. Contract status: Rivers, 39, is set to become an unrestricted free agent. Fit ...
- Shilpa Shetty doesn't believe in aging stereotypeson January 19, 2021 at 10:25 am
Actress Shilpa Shetty says she does not believe in the stereotyping people face once they cross a certain age. Shilpa writes on her Instagram, "Ageing is a process we have absolutely no control over.
- Study explores how choice of foods influences aging and lifespan in fruit flieson January 19, 2021 at 10:03 am
Having a choice of foods may accelerate aging and shorten the lifespan of fruit flies, according to a study published today in the open-access eLife journal.
- An Unexpected Meditation on Aging and Human Connection in THE MOLE AGENT on POV, Monday, January 25 at 9:30 pmon January 19, 2021 at 9:39 am
POV: ‘The Mole Agent’ Airs Monday, January 25, 2021 at 9:30 pm “The most heartwarming spy movie ever made.” — Eric Kohn, IndieWire “A refreshing, beautifully made documentary set in a nursing home ...
- “Holy Grail” – Hyperbaric Oxygen Treatments Reverse Aging Process in First Clinical Trialon January 19, 2021 at 9:08 am
Study finds hyperbaric oxygen treatments halt the aging of blood cells and reverses the aging process. A new study from Tel Aviv University (TAU) and the Shamir Medical Center in Israel indicates that ...
- The positive perception of agingon January 19, 2021 at 4:00 am
Some positive developments are also apparent. Educational levels are increasing, average US life expectancy increased from 68 years in 1950 to 79 years in 2013. Additionally, the poverty rate of ...
- Automakers Redesign Cars for Millions of Aging Drivers in Japanon January 18, 2021 at 12:27 pm
Automakers in Japan, where almost 30% of the population is 65 or older, are taking the lead on adapting cars so the nation’s legions of elderly drivers can feel more confident -- and be safer -- ...
- Anti-Aging Cosmetics Market Size 2021 Trends, Revenue, Key Players, Growth, Share and Forecast Till 2027on January 18, 2021 at 11:15 am
A rapid increase in medical tourism for cosmetic surgeries, growing consumer awareness about the benefits of anti-aging products, and rising focus on maintaining youthful skin are key factors ...
- 9 Betty White Quotes About Life and Aging, in Celebration of Her 99th Birthdayon January 17, 2021 at 5:30 am
Don't take yourself to seriously." It's an adage the beloved Golden Girls star lives by, and especially as she celebrates her 99th birthday on Sunday. Speaking with People magazine on Wednesday ahead ...
- Scientists identify animal model to study human musculoskeletal agingon January 14, 2021 at 10:49 am
There are many components to aging, both mental and physical. When it comes to the infrastructure of the human body - the musculoskeletal system that includes muscles, bones, tendons and cartilage - ...
via Bing News