Research led by the Centenary Institute in Sydney has found a brand new target for treating drug resistant tuberculosis; our scientists have uncovered that the tuberculosis bacterium hijacks platelets from the body’s blood clotting system to weaken our immune systems.
Tuberculosis is far from eradicated around the world and still infects more than 1,400 people per year in Australia. Antibiotic resistant tuberculosis is particularly deadly and expensive to treat,
costing up to $250,000 to treat a single case in Australia. Scientists at the Centenary Institute have been working on new ways to treat tuberculosis by increasing the effectiveness of the immune
Using the zebrafish model of tuberculosis, the researchers used fluorescent microscopy to observe the build-up of clots and activation of platelets around sites of infection . Senior author and head of the Centenary’s Immune-Vascular Interactions laboratory, Dr Stefan Oehlers, says “the zebrafish gives us literal insight into disease processes by watching cells interacting in real time”.
Following their hunch that these platelets were being tricked by the infection into getting in the way of the body’s immune system, the researchers treated infections with anti-platelet drugs, including widely available aspirin, and were able to prevent hijacking and allow the body to control infection better.
Dr Elinor Hortle, lead author of the paper published in The Journal of Infectious Diseases, and Research Officer in Centenary’s Immune-Vascular Interactions laboratory says “This is the first
time that platelets have been found to worsen tuberculosis in an animal model. It opens up the possibility that anti-platelet drugs could be used to help the immune system fight off drug resistant
There are over 1.2 million Australians living with latent tuberculosis, a non-infectious form of TB that puts them at risk of developing the active disease. “Our study provides more crucial evidence
that widely available aspirin could be used to treat patients with severe tuberculosis infection and save lives,” says Dr Hortle.
Video 1 – Green platelets
zooming around the
vasculature of a zebrafish
embryo. Note some platelets
stick to red macrophages
infected by blue bacteria
Video 2 – Zoomed in version
of video 1 with visible blood
Green platelets sticking to
red blood vessels next to
sites of infection by blue
bacteria. Pathogenic platelets
are the green cells that stick
next to the bacteria for a few
The Latest on: Tuberculosis
[google_news title=”” keyword=”tuberculosis” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Tuberculosis
- PSAC: 5 local manufacturers to produce anti-tuberculosis medson February 23, 2024 at 10:21 am
Five local drug manufacturers are slated to produce anti-tuberculosis medicines, said the Private Sector Advisory Council (PSAC) Health Sector Group on Friday. In 2022, President Ferdinand Marcos Jr.
- 'Small cluster' of tuberculosis cases in Byker that 'may have been transmitted locally' reportedon February 23, 2024 at 12:00 am
A "small cluster" of cases of tuberculosis (TB) have been reported in the Byker area of Newcastle this year, the UK Health Security Agency has confirmed.
- Fighting the flu: The surprising power of a century-old vaccine for tuberculosison February 22, 2024 at 7:46 am
As Canada's flu season collides with record strep A cases and ongoing COVID-19 concerns, a new study is shedding light on our understanding of respiratory immune responses. Scholars from the Research ...
- Man catches ‘incredibly rare FISH tuberculosis’ after biting his nails until he bledon February 22, 2024 at 1:20 am
AN AQUARIUM cleaner was struck down with an “incredibly rare” form of fish tuberculosis because he bit his nails, an employment tribunal has heard. Joshua Hodges ground his nails “very low” — to ...
- An Analysis Of Prehistoric Bones Unearthed In Hungary In 1932 Revealed That Neanderthals Living In Central Europe Suffered From Tuberculosis Over 35,000 Years Agoon February 21, 2024 at 6:00 am
Around 35,000 years ago, Neanderthals living in Central Europe suffered from tuberculosis. The new finding has left scientists wondering whether the disease played a part in the extinction of the ...
- Mass. town says it’s ‘not facing a public health crisis’ amid tuberculosis concernson February 20, 2024 at 8:37 am
A Massachusetts town says it’s “not facing a public health crisis” amid the recent rise in concerns over tuberculosis cases that have popped up.
- Tuberculosis case reported at Arkansas high schoolon February 19, 2024 at 10:12 pm
SPRINGDALE, Ark. (KAIT) - Arkansas health officials confirmed a case of tuberculosis was found at a high school in the state. According to content partner KNWA, the case was confirmed to be at the ...
- Tuberculosis confirmed at high school in Arkansas, ADH sayson February 18, 2024 at 6:05 pm
SPRINGDALE, Ark. — A tuberculosis (TB) case has been confirmed at Har-Ber High School, according to the Arkansas Department of Health's (ADH) communications director. Meg Mirivel with ADH shared the ...
- No additional CCSD tuberculosis cases identified after case found at schoolon February 16, 2024 at 4:49 am
The Southern Nevada Health District said no additional tuberculosis were found after one active case at a local school.
- Tuberculosis cases rise, but public health agencies say they lack the resources to keep upon February 12, 2024 at 6:01 am
Until COVID-19, tuberculosis was the world's deadliest infectious disease, killing about 1.5 million people annually.
via Bing News