An adhesive gel packed with light-activated chemicals can seal cuts or ulcers on the cornea —the clear surface of the eye — and then encourage the regeneration of corneal tissue, according to a preclinical study published online today in Science Advances. The new technology, named GelCORE (gel for corneal regeneration), could one day reduce the need for surgery to repair injuries to the cornea, including those that would today require corneal transplantation.
“Our hope is that this biomaterial could fill in a major gap in technology available to treat corneal injuries,” said co-corresponding author Reza Dana, MD, Director of the Cornea and Refractive Surgery Service at Massachusetts Eye and Ear and the Claes H. Dohlman Professor of Ophthalmology at Harvard Medical School. “We set out to create a material that is clear, strongly adhesive, and permits the cornea to not only close the defect, but also to regenerate. We wanted this material to allow the cells of the cornea to mesh with the adhesive and to regenerate over time to mimic something as close to the native cornea as possible.”
Corneal injuries are a common cause of visual impairment worldwide, with more than 1.5 million new cases of corneal blindness reported every year. The current standard of care for filling in cuts, thinning areas, or holes in the cornea (corneal defects) includes the use of synthetic glues or surgery to patch the eye with tissue and/or corneal transplants. The synthetic glues currently available are rough, inherently toxic to tissues, difficult to handle, and can lead to significant vision loss due to the material’s opacity and poor integration with corneal tissues. Corneal transplants carry risks of post-transplant complications, including infection or rejection.
With the goal of addressing this unmet clinical need, researchers on the Science Advances report set out to develop an adhesive designed for long-term integration with the cornea.
The team engineered an adhesive biomaterial, GelCORE, made of chemically modified gelatin and photoinitiators, which are activated by a short-time exposure to blue light. Initially, the gel is a clear, viscous material designed to be applied with a dropper or syringe. When exposed to light, the material hardens, taking on the biomechanical features of a native cornea. And, over time, the cornea cells gradually grow into and become one with this material. Thus, GelCORE is similar to the native cornea — highly transparent, able to bond to the native tissue, and capable of supporting cell and tissue regeneration.
Similar adhesive technologies have been designed for lung and other eye defects, but GelCORE is the first to use visible blue light as opposed to ultraviolet light, which carries a level of toxicity that blue light does not.
In the Science Advances report, the researchers describe their assessments of GelCORE in a preclinical model of corneal injury. They applied GelCORE at 20 percent concentration to corneal defects of 3mm, and then applied visible light for 4 minutes. Immediately after the light exposure, they observed firm adhesion of the gel to the corneal defect. One day later, they observed a transparent, smooth eye surface, with a surrounding cornea that was clear and without inflammation. One week after application, the gel could still be observed on the defect site in the cornea and remained transparent. Over time, the tissue showed signs of regeneration, with cells of the new tissue showing similarities between regenerated tissue and native tissue.
The study authors also note that the properties of GelCORE can be finely controlled by varying the concentration and the amount of time exposed to light — offering the possibility of changing the formulation for different types and severities of eye injuries. “We’re now looking to make certain modifications for different applications,” Dr. Dana said. “We envision, if a patient comes in with a big laceration, they might receive formulation A. If they come in with a corneal scar, they might get formulation B.” The authors also hope to begin clinical trials to test the technology in human patients in approximately one year.
The Latest on: Biomaterial
via Google News
The Latest on: Biomaterial
- A Novel Implant Plastic Announcedon October 11, 2021 at 11:24 am
Samaplast produces plastic injection molded parts, as well as medical components and implants. Together, the companies have developed VESTAKEEP ® Fusion, an osteoconductive high-performance polymer ...
- KDU and CUI, Pakistan collaborate on advanced biomaterial researchon October 10, 2021 at 6:53 pm
University Islamabad in Pakistan (CUI) and General Sir John Kotelawala Defence University (KDU) in Sri Lanka have inked a Document of Understanding to collaborate on advanced biomaterial research.
- Biomaterial Wound Dressing Market Growth, Size, Analysis, Outlook by 2021 – Trends, Opportunities and Forecast to 2028on October 8, 2021 at 5:06 am
Biomaterial Wound Dressing Market report makes the business well acquainted with insightful knowledge of the global, regional and local market statistics. It has the most detailed market ...
- The global biomaterials market was valued at $122...on October 7, 2021 at 1:28 am
Reportlinker.com announces the release of the report "Biomaterials Market - A Global and Regional Analysis: Focus ...
- Biomaterial coatings company launches full-service, on-site facility for medical device OEMson October 5, 2021 at 5:00 pm
A provider of hydrophilic biomaterial coatings for medical devices, Biocoat (Horsham, PA) has launched a full-service, on-site facility for the application of its Hydak coatings to customer’s devices.
- Researchers develop new method to predict biomaterial's capacity to induce tissue regenerationon October 5, 2021 at 4:57 pm
Researchers from the Polymer and Advanced Materials Group at the Universitat Jaume I in Castellón have developed an in vitro method to predict the capacity of a biomaterial to induce bone and ...
- Kemira opens its new R&D center in Shanghaion October 2, 2021 at 12:49 am
Kemira Oyj, Press release, September 30, 2021 at 9.00 am (EEST) Kemira opens its new R&D center in Shanghai Kemira, a global lead ...
- Dental Biomaterial Market Size 2021: In-Depth Industry Analysis, Top Manufacturers, Top Countries Data, Opportunities and Forecast 2027on October 1, 2021 at 2:55 am
Oct 01, 2021 (The Expresswire) -- "Final Report will add the analysis of the impact of COVID-19 on this industry." Global “Dental Biomaterial Market” ...
- Cellulose-Based Biomaterial Is Stronger than Steel and Spider Silkon September 29, 2021 at 5:00 pm
A team in Sweden has made a significant advancement to this end with the invention of what they say is the strongest biomaterial ever developed. The researchers, who hail from KTH Royal Institute of ...
- 3D-Printable Biomaterial Takes Shape for Tissue Scaffoldson September 29, 2021 at 5:00 pm
The 4Degra biodegradable and customizable biomaterial could provide support for healing across tissue types, including soft tissue post-surgery or for support in orthopedics, and it could eliminate ...
via Bing News