Scientists observe drug target that can reduce pain when activated
A research group at Hiroshima University observed a potential new target for chronic pain treatment. Further research using this receptor could lead to new, more effective drugs to use in pain-relieving treatment for chronic pain.
Conditions that cause chronic pain can be difficult to manage. These include sciatica, cancer and rheumatoid arthritis. Chronic pain mechanisms are complicated, which is one of the reasons why pain management is so difficult, explains Professor Norimitsu Morioka of the Department of Pharmacology, Graduate School of Biomedical & Health Sciences, Hiroshima University. This difficulty decreases the quality of life of patients that, in many cases, can suffer from constant pain with little to no relief. General-purpose pain-relieving medication is often ineffective. Even morphine, possibly the best painkiller according to Assistant Professor Yoki Nakamura, also of the Department of Pharmacology, can fail to inhibit pain in cancer patients.
“Chronic pain is increasing worldwide […] associated with increasing population,” warns Morioka. The increasing number of sufferers of chronic pain means the establishment of new therapeutics is urgent, hence why the results of these types of studies can have important consequences on healthcare for these patients.
Previous research had shown that activating a type of cell receptor (REV-ERBs) that sends chemical signals inside the cell to block the production of certain genes regulates pain-causing and inflammatory molecules inside the body. Such research had shown that a molecule used to ‘turn on’ the REV-ERBs had decreased the production of inflammatory molecules in immune cells but
“Nobody checked the effect of REV-ERBs agonist [stimulator] on nociceptive behaviors [pain reactions] or chronic pain so first we checked the effect of REV-ERBs agonist on chronic pain,” explains Nakamura.
Until now, research has also only looked into one type of pain model at a time. Morioka elaborates that
“I think it is not enough to reduce by one target […] I think it is important to cover a lot of molecules mediating chronic pain,” and REV-ERBs seems to be a fitting target “So it is very exciting.”
The research group applied this knowledge to determine if activating the nuclear receptor REV-ERBs in specialized spinal cord cells (astrocytes) results in pain relief in mice. The team treated mice with differing levels of pain sensitivity with molecules that turned on REV-ERBs. The molecules studied can be easily found in today’s pain-relieving drugs according to the team. To test whether there was a notable effect on pain; mice were touched with a filament on their hind paw. Pain was recorded when mice raised their paw away from the filament. Light touches made mice with chronic pain react whereas ‘normal’ mice only moved when the force was increased. Mice with chronic pain when treated with a REV-ERBs stimulator did not react to the lighter touches (depending on the type of chronic pain they had). Through these observations, the research group concluded they did not feel as much pain as the untreated mice with the same type of chronic pain.
Based on these results, the researchers believe that this new target for pain relief could benefit many types of chronic pain sufferers. They plan to perform further research and drug screening experiments to develop new drugs for various types of chronic pain relief.
The Latest on: Chronic pain relief
via Google News
The Latest on: Chronic pain relief
- Five key pain management approaches that can help children's recovery and resilience after injuryon August 1, 2022 at 7:25 pm
In Australia, as many as one in four children, and one in five adults experience chronic pain ... it's equally important to understand that pain and injury do not always align. "As adults, one of the ...
- 'Night and day' | New procedure helped East Tennessee woman go from prescription opioids to pain-freeon August 1, 2022 at 1:39 pm
Dr. James Choo at Pain Consultants of East Tennessee said the new procedure could be a "game changer" for chronic pain patients.
- Get relief from chronic back painon August 1, 2022 at 7:56 am
Mindi’s pain started about a decade ago. She used to be a traveling nurse and was sitting in a car for long periods of time and working a shift was difficult for her. She ended up switching to a ...
- Medical Musings: Lower back pain is a leading cause of disability worldwideon August 1, 2022 at 5:00 am
Untreated lower back pain can have an injurious effect on one’s physical and emotional well-being — fortunately, health care today has solutions to alleviate the problem in most cases.
- Waunakee Chiropractic Adjustment For Sports Injury Pain | Treatment Updatedon July 31, 2022 at 11:16 pm
For more information see As a result of its updates, Hellenbrand Rabideaux Chiropractic now offers a wider array of care plans to its Waunakee community. The move puts the practice, led by local ...
- CBD Could Help Cops Get Relief From Stress, Insomnia, and Chronic Pain. But Using It Puts Their Job in Jeopardyon July 29, 2022 at 3:31 pm
and ease the constant pain that was shooting through his back. At one point, he found himself tempted to try CBD, a widely available cannabis derivative that can offer relief from many ailments. “It ...
- Texas Original: Survey says Texas GOP Voters Support Medical Cannabis Treatment for Chronic Painon July 28, 2022 at 8:30 am
The survey also found that 72% of Republican primary voters in Texas favored allowing physicians to prescribe medical marijuana as an alternative to opioids for treating chronic pain patients. Michael ...
- Reliq Health Technologies, Inc. Announces New Contracts with Four US Pain Management Clinicson July 27, 2022 at 12:02 am
We are very excited to be welcoming four Pain Management clinics in California as new clients,” said Dr. Lisa Crossley, CEO at Reliq Health Technologies, Inc. “There are over 5 Million Medicare ...
- The Future of Pain Relief is Now: Kailo Patch Reviewon July 26, 2022 at 10:40 am
Kailo is a skin patch that uses nanotechnology rather than opioids to target pain. Yes! You read that correctly; these patches are free from prescription drugs! Each Kailo patch is made using patented ...
- Chronic Pain: We Need to Ask “Why?”on July 21, 2022 at 11:45 am
According to the CDC, approximately 50 million people in the US are living in chronic pain. We all know about the opioid crisis, and this knowledge has done nothing to help alleviate pain many are ...
via Bing News