Using nanotechnology, UCF researchers have developed the first rapid detector for dopamine, a chemical that is believed to play a role in various diseases such as Parkinson’s, depression and some cancers.
Studies show too much dopamine could be associated with some cancers, while low dopamine could be associated with Parkinson’s disease and depression. The new technique developed at UCF requires only a few drops of blood, and results are available in minutes instead of hours because no separate lab is necessary to process the sample.
The new technology was described in a recent study in the journal Nano Letters.
More than half a million people in the United States have Parkinson’s and major episodes of depression affect about 16 million adults a year.
Current methods to detect dopamine are time consuming, require rigorous sample preparation, including blood-plasma separation, as well as specialized laboratory equipment. With this device, however, a few drops of blood on a palm-sized, rectangular chip is all that is needed.
“A neurotransmitter like dopamine is an important chemical to monitor for our overall well-being so we can help screen out neural disorders like Parkinson’s disease, various brain cancers, and monitor mental health,” said Debashis Chanda, an associate professor in UCF’s NanoScience Technology Center and the study’s principle investigator. “We need to monitor dopamine so that we can adjust our medical doses to help address those problems.”
Plasma is separated from the blood within the chip. Cerium oxide nanoparticles, which coat the sensor surface, selectively capture dopamine at microscopic levels from the plasma. The capture of dopamine molecules subsequently changes how light is reflected from the sensor and creates an optical readout indicating the level of dopamine.
Sudipta Seal, an engineering professor and chair of UCF’s Department of Materials Science and Engineering, said the use of cerium oxide nanoparticles was an important part of the sensor’s success.
“Getting the sensor to be sensitive to dopamine had been quite the challenge for researchers for a while, but using altered cerium oxide nanostructures on the sensing platform was key in making the sensor work,” Seal said.
Chanda co-developed the sensor with Abraham Vázquez-Guardado, a graduate of UCF’s College of Optics and Photonics and now a postdoctoral fellow at Northwestern University.
Vázquez-Guardado said reduced steps and processing make the test cost effective, and it can also be performed at the patient’s side rather than in a separate lab.
“There is no preprocessing needed,” he said. “Our plan was to make a much quicker, enzyme-free kind of detection.”
The Latest on: Dopamine sensor
via Google News
The Latest on: Dopamine sensor
- These are the 9 best Cyber Monday deals at Amazon — up to 60 percent offon November 29, 2021 at 8:03 am
As expected, Amazon is coming through in a major way for Cyber Monday. Your favorite one-stop online shop has reduced prices on some of its all-time bestselling, top-rated products — we’re talking TCL ...
- These are the 9 best Cyber Monday deals at Amazon — up to 60 percent offon November 29, 2021 at 12:02 am
All you have to do is point, click and wait for the dopamine hit of that box being ... a keypad to arm and disarm the system and one contact sensor for windows and doors. And you control it ...
- Dopamine Agents Market 2022: Up-Stream and Downstream Fundamentals, Import-Export Data, Rapidly Increasing Growth Rate and Revenue Share till 2027on November 22, 2021 at 5:22 pm
Nov 22, 2021 (The Expresswire) -- "Final Report will add the analysis of the impact of COVID-19 on this industry" "Dopamine Agents Market" Report offers complete research based on recent industry ...
- Researchers Transplant Functional Dopaminergic Neurons Derived from Human Embryonic Stem Cells (VIDEO)on November 9, 2021 at 3:59 pm
Parkinson’s disease is a progressive neurodegenerative disorder marked by the loss of dopamine-producing neurons in the brain. Since dopamine is involved in the regulation of movement and ...
- Expectations and dopamine can affect outcome of SSRI treatmenton November 8, 2021 at 7:51 am
Levels of dopamine and the placebo effect can determine whether patients with social anxieties improve when treated with SSRIs. A new study shows the effect was four times higher for patients with ...
- New Brain Probe Maps Dopamine in Brain to Help Study Psychiatric Drugs and Diseaseson November 7, 2021 at 4:00 pm
Researchers at University of California, Berkeley have developed special sensors that provide a look at the location and concentration of neurotransmitter chemicals, such as dopamine, inside ...
- Gene therapy boosts Parkinson's disease drug benefitson November 3, 2021 at 9:00 am
In late-stage Parkinson's disease, the drug levodopa becomes less effective in treating symptoms because of the inexorable loss of dopamine-releasing neurons. But a new Northwestern Medicine ...
- Dopamine hypothesis of schizophreniaon October 1, 2021 at 6:16 am
The dopamine hypothesis of schizophrenia or the dopamine hypothesis of psychosis is a model that attributes the positive symptoms of schizophrenia to a disturbed and hyperactive dopaminergic signal ...
via Bing News