Using nanotechnology, UCF researchers have developed the first rapid detector for dopamine, a chemical that is believed to play a role in various diseases such as Parkinson’s, depression and some cancers.
Studies show too much dopamine could be associated with some cancers, while low dopamine could be associated with Parkinson’s disease and depression. The new technique developed at UCF requires only a few drops of blood, and results are available in minutes instead of hours because no separate lab is necessary to process the sample.
The new technology was described in a recent study in the journal Nano Letters.
More than half a million people in the United States have Parkinson’s and major episodes of depression affect about 16 million adults a year.
Current methods to detect dopamine are time consuming, require rigorous sample preparation, including blood-plasma separation, as well as specialized laboratory equipment. With this device, however, a few drops of blood on a palm-sized, rectangular chip is all that is needed.
“A neurotransmitter like dopamine is an important chemical to monitor for our overall well-being so we can help screen out neural disorders like Parkinson’s disease, various brain cancers, and monitor mental health,” said Debashis Chanda, an associate professor in UCF’s NanoScience Technology Center and the study’s principle investigator. “We need to monitor dopamine so that we can adjust our medical doses to help address those problems.”
Plasma is separated from the blood within the chip. Cerium oxide nanoparticles, which coat the sensor surface, selectively capture dopamine at microscopic levels from the plasma. The capture of dopamine molecules subsequently changes how light is reflected from the sensor and creates an optical readout indicating the level of dopamine.
Sudipta Seal, an engineering professor and chair of UCF’s Department of Materials Science and Engineering, said the use of cerium oxide nanoparticles was an important part of the sensor’s success.
“Getting the sensor to be sensitive to dopamine had been quite the challenge for researchers for a while, but using altered cerium oxide nanostructures on the sensing platform was key in making the sensor work,” Seal said.
Chanda co-developed the sensor with Abraham Vázquez-Guardado, a graduate of UCF’s College of Optics and Photonics and now a postdoctoral fellow at Northwestern University.
Vázquez-Guardado said reduced steps and processing make the test cost effective, and it can also be performed at the patient’s side rather than in a separate lab.
“There is no preprocessing needed,” he said. “Our plan was to make a much quicker, enzyme-free kind of detection.”
The Latest on: Dopamine sensor
via Google News
The Latest on: Dopamine sensor
- Researchers find new way to enhance the sensitivity of electrochemical micro-sensorson February 20, 2021 at 9:14 am
A team led by researchers at the New York University Tandon School of Engineering have found a new way of enhancing the performance of electrochemical micro-sensors.
- Researchers flip the switch to make microsensors super sensitive to biomoleculeson February 18, 2021 at 6:36 am
However, the team made a surprising observation that the amplitude of the sensor output in response to dopamine molecules was increased by reducing the operation voltage. “We initially thought that ...
- Researchers flip the switch to make microsensors super sensitive to biomoleculeson February 18, 2021 at 5:30 am
A team led by researchers at the New York University Tandon School of Engineering have found a new way of enhancing the performance of electrochemical micro-sensors. This discovery could lead to the ...
- A versatile GPCR toolkit to track in vivo neuromodulation: not a one-size-fits-all sensoron February 18, 2021 at 1:09 am
GPCR sensor design takes advantage of the fact that most neuromodulators harbor GPCRs as their native receptors, and builds on protein engineering expertise acquired through work on genetically ...
- Biosensors & bioelectronicson February 16, 2021 at 4:00 pm
Unmodified and multi-walled carbon nanotube modified tetrahedral amorphous carbon (ta-C) films as in vivo sensor materials for sensitive and selective detection of dopamine.
- Search Results for: 20on February 9, 2021 at 4:01 pm
You would have guessed that the little hits of dopamine accompanying each tick upward of a number would be so addictive? The details of the API changes were made public in April, and for the subs ...
- cAMPr: A single-wavelength fluorescent sensor for cyclic AMPon February 2, 2021 at 4:00 pm
Although this sensor is a step forward for cAMP imaging ... Neurons were treated with 40 μM forskolin, DMSO, 100 μM GABA, or 100 nM to 1 mM dopamine at the times indicated in the figure legends. All ...
- Molecular-Level Functional Magnetic Resonance Imaging of Dopaminergic Signalingon February 2, 2021 at 4:00 pm
The molecular sensor revealed a quantitative spatiotemporal map of dopamine release in the ventral striatum, a brain area involved in processing rewards. We demonstrate a technique for mapping brain ...
via Bing News