Imagine a day when a bioprinter filled with a patient’s own cells can be wheeled right to the bedside to treat large wounds or burns by printing skin, layer by layer, to begin the healing process. That day is not far off.
Wake Forest Institute for Regenerative Medicine (WFIRM) scientists have created such a mobile skin bioprinting system – the first of its kind – that allows bi-layered skin to be printed directly into a wound.
“The unique aspect of this technology is the mobility of the system and the ability to provide on-site management of extensive wounds by scanning and measuring them in order to deposit the cells directly where they are needed to create skin,” said Sean Murphy, PhD, a WFIRM assistant professor who was lead author of the paper published this month in Nature’s Scientific Reports journal.
Affecting millions of Americans, chronic, large or non-healing wounds such as diabetic pressure ulcers are especially costly because they often require multiple treatments. It is also estimated that burn injuries account for 10-30 percent of combat casualties in conventional warfare for military personnel.
The major skin cells – dermal fibroblasts and epidermal keratinocytes – are easily isolated from a small biopsy of uninjured tissue and expanded. Fibroblasts are cells that synthesize the extracellular matrix and collagen that play a critical role in wound healing while keratinocytes are the predominant cells found in the epidermis, the outermost layer of the skin.
The cells are mixed into a hydrogel and placed into the bioprinter. Integrated imaging technology involving a device that scans the wound, feeds the data into the software to tell the print heads which cells to deliver exactly where in the wound layer by layer. The bioprinter deposits the cells directly into the wound, replicating the layered skin structure, and accelerating the formation of normal skin structure and function.
The researchers demonstrated proof-of-concept of the system by printing skin directly onto pre-clinical models.
The next step is to conduct a clinical trial in humans. Currently, skin grafts to treat wounds and burns are the “gold standard” technique, but adequate coverage of wounds is often a challenge particularly when there is limited availability of healthy skin to harvest. Skin grafts from donors are an option, but risk immune rejection of the graft and scar formation. With the WFIRM bioprinter system the researchers could see new skin forming outward from the center of the wound and this only happened when the patient’s own cells were used, because the tissues were accepted and not rejected.
“The technology has the potential to eliminate the need for painful skin grafts that cause further disfigurement for patients suffering from large wounds or burns,” said WFIRM Director Anthony Atala, MD, and a co-author of the paper. “A mobile bioprinter that can provide on-site management of extensive wounds could help to accelerate the delivery of care and decrease costs for patients.”
“If you deliver the patient’s own cells, they do actively contribute to wound healing by organizing up front to start the healing process much faster,” said James Yoo, MD, PhD, who led the research team and co-authored the paper. “While there are other types of wound healing products available to treat wounds and help them close, those products do not actually contribute directly to the creation of skin.”
Learn more: Mobile Bedside Bioprinter Can Heal Wounds
The Latest on: Skin bioprinting system
via Google News
The Latest on: Skin bioprinting system
- What is Bioprinting?on December 23, 2020 at 5:44 pm
Post-operatively, the immune system of the transplant recipient ... Several studies to date have fabricated human skin via bioprinting. In each case, the bio-ink comprised donor keratinocytes ...
- Fibrous protein finding may lead to improved bioprinting, tissue engineeringon December 16, 2020 at 4:00 pm
Fibrous proteins such as collagen and fibrinogen form a thin solid layer on the surface of an aqueous solution similar to the 'skin' that forms ... to more efficient bioprinting and tissue ...
- 3D Bioprinting Market to Record Rapid Revenue Growth from 2020 to 2026 |3D Systems Corporation, Aspect Biosystems Ltd, GeSIM GmbH, Allevi Incon December 16, 2020 at 8:49 am
For a cosmetic company, the advantage will be the ability to economically and ethically test products (i.e., not on animals) across varying skin types, for more accurate results. – Several ...
- UAE Health Ministry introduces latest 4D bioprinting technology to treat wounds and burnson December 8, 2020 at 2:22 am
After using the 4D bioprinting technology, he applies the skin graft to cover the wound ... we’ll consolidate the capabilities of our health system and take one step further towards health ...
- President's Quarterly Reporton October 1, 2019 at 1:34 pm
Louis Piper, associate professor of physics, is the principal investigator for a grant that will help Binghamton University acquire a HArd X-ray Photoelectron Spectroscopy (HAXPES) system ... and for ...
- 3R competencieson June 27, 2019 at 8:50 am
Key words: ES cells, iPS cells, microtissue, brain organoids, microfluidic system, hanging drops ... bone organoids, 3D bioprinting, time-lapsed microCT imaging, bioreactors for mechanical stimulation ...
- 3D printers could soon make human skinon April 16, 2019 at 1:10 pm
But growing skin is a slow and complex procedure. 3D bioprinting would speed things up. Instead of waiting for skin to develop in a laboratory, cosmetic companies could build models more quickly ...
- Honey, I printed a thyroid glandon April 27, 2015 at 8:52 am
The existing system recognizes only molecules, tissues, organs, organ systems and organisms. The object printed at 3D Bioprinting Solutions ... blood vessels, skin and hair, as well as cartilage ...
- Soon, Your Doctor Could Print a Human Organ on Demandon April 23, 2015 at 11:05 am
Wake Forest staffers have implanted bioprinted skin, ears, bone, and muscle on laboratory animals, where they grew successfully into the surrounding tissue. To evangelists of bioprinting ...
- The CNN 10: Healing the Futureon April 25, 2014 at 5:05 pm
In a 2012 study, they implanted a chip under the skin below the waistlines of eight ... the doctors taught Nick’s immune system to attack his cancer in much the same way he’d fight off the ...
via Bing News