An engineered virus kills cancer cells more effectively than another virus currently used in treatments, according to Hokkaido University researchers.
Hokkaido University researchers have engineered a virus that selectively targets and kills cancer cells. The virus, called dl355, has an even stronger anticancer effect than another engineered virus currently used in clinical practice, according to a study published in the journal Oncology Reports.
Molecular oncologist Fumihiro Higashino and colleagues deleted a gene involved in viral replication, called E4orf6, from a type of adenovirus. The team previously discovered that E4orf6 stabilizes a type of mRNA called ARE-mRNAs in the infected cells enabling viral replication. ARE-mRNAs are known to be stable in stressed cells and cancer cells, but rapidly degrade in normal cells.
In laboratory tests, they found that their modified adenovirus, called dl355, replicated and increased its number significantly more in cancer cells than it did in normal cells. Higashino explains “The E4orf6-lacking virus relies on the stable ARE-mRNAs in cancer cells for its replication.”
Some viruses can be used to treat cancers, as they replicate within the cells until they burst and die. The researchers infected several types of cultured cancer cells with 100 dl355 virus particles per cell and found that nearly all the cancer cells died within seven days. In contrast, most normal cells infected with the virus did not die, even after seven days. Several cancer cell lines managed to survive low doses of dl355, but all cancer cells were killed by the virus as the dose was increased. Tumour growth was also significantly suppressed when dl355 was administered to human tumour cells grown in mice.
Finally, the team compared the anticancer effects of dl355 with another anticancer adenovirus currently used in clinical practice, called dl1520. dl355 replication was higher in all cancer cell lines tested, including cervical and lung cancer cells, and was better at killing all but one type of cancer cell, compared to dl1520. Both viruses only killed very few normal cells.
The findings suggest that dl355 has potential to be an effective anticancer treatment, the team concludes. They suggest enhancing the stabilization of ARE-mRNAs in cancer cells could even further strengthen its effect, but Professor Higashino notes that further research is required. “While we think dl355 has the potential to be an effective treatment method in dealing with many types of cancers, much more research needs to be done. When we think of a timeline, at least five more years of further research may be required, possible more, on top of clinical trials,” Professor Higashino noted.
Learn more: Engineering a cancer-fighting virus
The Latest on: Engineered virus
[google_news title=”” keyword=”engineered virus” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Engineered virus
- Does Red Cross Ask Potential Blood Donors If They've Received a COVID-19 Vaccine?on February 21, 2024 at 4:48 pm
This is the reality of the situation for people with HIV. Zeroing in on the point: What if the virus is dead or genetically modified so that it can't replicate? Is that safe? Yes, this is fine.
- The truth about GMOs: Are genetically modified crops all bad?on February 21, 2024 at 11:03 am
Explore the truth about GMOs, their benefits, and concerns, from Hawaii's papaya industry revival to environmental impact.
- Long covid is not the only chronic condition triggered by infectionon February 21, 2024 at 9:30 am
S OME INFECTIONS—HIV/AIDS, for example—are chronic. If you catch one you are stuck with it indefinitely, unless a treatment exists to clear away the guilty pathogen. Many, though, are acute. Unless ...
- How the body plays defense against colds and the fluon February 21, 2024 at 3:14 am
Your body might be making you feel horrible, but it’s all designed to make whatever is invading you feel even worse.
- Candel Therapeutics Inc (CADL)on February 20, 2024 at 11:46 am
Its engineered viruses are designed to induce immunogenic death through viral-mediated cytotoxicity in cancer cells, therefore releasing tumor neo-antigens and creating a pro-inflammatory ...
- Replication-selective virotherapy for cancer: Biological principles, risk management and future directionson February 19, 2024 at 6:50 am
If reversion to a wild-type, non-selective virus were to occur, would the transgene still be expressed? What would be the consequences of a recombination of the engineered virus with a related ...
- How an ancient virus made our brains complexon February 15, 2024 at 7:00 am
An ancient viral infection may have given animals the tools to become fast, coordinated and smart, a new study has found. According to a paper published on Thursday in Cell, complex nervous systems ...
- This Genetically Engineered Petunia Glows in the Dark and Could Be Yours for $29on February 14, 2024 at 12:30 pm
The engineered “firefly petunia” emits a continuous green glow thanks to genes from a light-up mushroom ...
- Alaskapox: elderly man becomes first known death from viruson February 13, 2024 at 8:13 pm
The virus recently discovered in Alaska is transmitted from small mammals and symptoms normally include a rash and muscle pain ...
- CRISPRed Pigs: Precision Porcine Gene Editing Combats PRRS Virus Threaton February 13, 2024 at 4:00 pm
The Genus team describes a scaled gene editing program that introduced “a single modified CD163 allele into four genetically diverse, elite porcine lines.” The work produced healthy pigs that ...
via Bing News