Chemists and microbiologists at Tübingen University discover sugar molecule that inhibits the growth of plants and microorganisms and is harmless to human cells ? An alternative to controversial glyphosate?
Researchers at the University of Tübingen have discovered a natural substance that could compete with the controversial herbicide glyphosate: The newly discovered sugar molecule synthesized from cyanobacteria inhibits the growth of various microorganisms and plants but is harmless to humans and animals. The joint study was led by Dr. Klaus Brilisauer, Professor Stephanie Grond (Institute of Organic Chemistry) and Professor Karl Forchhammer (Interfaculty Institute of Microbiology and Infection Medicine). It was published in the journal Nature Communications on Friday.
Active ingredients for pharmaceutical or agricultural use often originate from natural substances. These substances can consist of complex chemical structures, but can also be relatively simple. The ingenuity of such active ingredients often lies in their simplicity: Antimetabolites interact with vital processes in the cell by mimicking metabolic products. This disrupts the biological process, which can inhibit cell growth or even kill the cell.
Chemists and microbiologists at the University of Tübingen discovered a very unusual antimetabolite with an impressively simple chemical structure: A sugar molecule with the scientific name “7-deoxy-sedoheptulose (7dSh)”. Unlike ordinary carbohydrates, which usually serve as an energy source for growth, this substance inhibits the growth of various plants and microorganisms, such as bacteria and yeasts. The sugar molecule blocks a key enzyme of the shikimate pathway, a metabolic pathway that occurs only in microorganisms and plants. For this reason, the scientists classify the substance as harmless for humans and animals and have already demonstrated this in initial studies.
The rare deoxy sugar was isolated from cultures of the freshwater cyanobacterium Synechococcus elongatus, which is able to inhibit the growth of related bacterial strains. While searching for the cause of this growth inhibition, scientists succeeded in deciphering the structure of the natural compound. Through a newly developed method for the production of 7dSh – a chemoenzymatic synthesis – scientists were able to conduct extensive studies to determine the molecular mechanism of 7dSh.
In detail, the scientists used coupled high-resolution mass spectrometry to obtain precise insights into the inhibition mechanism and discovered that 7dSh blocks DHQS (Dehydroquinatesynthase), an enzyme of the shikimate pathway. One of the best-known inhibitors of this metabolic pathway to date is the controversial herbicide glyphosate. “In contrast to glyphosate, the newly discovered deoxy sugar is an entirely natural product. We believed it to have good degradability and low ecotoxicity,” says Dr. Klaus Brilisauer. So far, 7dSh inhibits plant growth promisingly. “We see an excellent opportunity here to use it as a natural herbicide.”
Scientists hope to replace controversial herbicides in the long term and thus reduce herbicide me-tabolites, which pose a health risk. However, effectiveness in the field, degradability in the soil and harmlessness to livestock and humans would have to be further investigated in comprehensive long-term studies for 7dSh.
The Latest on: Natural herbicide
via Google News
The Latest on: Natural herbicide
- Winning the Battle of Land and Fireon March 8, 2021 at 7:06 am
Control incompatible plant species most commonly associated with the cause and spread of wildfire by following these best practices.
- Biologicals and the Seven Wonders of the Corn Yield Worldon March 8, 2021 at 12:56 am
The Seven Wonders of the Corn Yield World produce a whole far greater than the individual parts, but which of the Seven Wonders can be deployed on multiple applications to obtain multiple increases in ...
- Bill seeks to ban the use of aerial herbicides in Maine forestson March 3, 2021 at 1:09 am
The Maine Legislature is considering a bill to ban aerial application of an herbicide used by large forest management companies for decades that has been linked to cancer and environmental damage. L.D ...
- Ghosts of past pesticide use can haunt organic farms for decadeson March 2, 2021 at 4:00 pm
Although the use of pesticides in agriculture is increasing, some farms have transitioned to organic practices and avoid applying them. But it's uncertain whether chemicals applied to land decades ago ...
- Herbicides aren't a solution for Tahoe Keys weeds | Tobi Tyleron March 2, 2021 at 10:18 am
The only thing this herbicide test will do is offer private homeowners false hope that there is an easy button to push for the inconvenience of weeds.
- Cover crop helps with weed controlon February 26, 2021 at 5:00 pm
Planting cover crops can be an effective weapon in the battle against weeds. There is a learning curve, however.
- Organic Meal Delivery Serviceson February 24, 2021 at 7:55 am
In an effort to get more produce for a lower cost, many farmers have come to rely on pesticides and herbicides for their crops. These complex chemicals ward off a variety of bugs and invasive plants ...
- 10 best organic baby bath time products you’ll want to steal for yourselfon February 24, 2021 at 2:05 am
From baby shampoo to body wash, be gentle on your baby's skin with organic baby bath time products from Little B, Bamford, Weleda, Little Butterfly and more ...
- Farmers urged to adopt organic and climate-smart farmingon February 23, 2021 at 7:39 pm
Daniel Kofi Abu, the Project Manager of Tropenbos-Ghana has urged farmers to adopt organic and climate-smart farming to improve the quality of food production and promote food security in the country.
- Five steps to protect water from the herbicide bentazoneon February 23, 2021 at 1:51 am
Farmers are at risk of losing the post-emergence herbicide bentazone – which is frequently used in pulses – because too much of the chemical is being ...
via Bing News