via Duke Medicine
Researchers hope to develop test that could detect early changes in blood flow to heart
A Duke Health pilot project suggests that in the near future, a blood test could show whether arteries carrying blood to the heart are narrow or blocked, a risk factor for heart disease.
According to the 40-person study published in the journal PLOS ONE, emergency patients who underwent a treadmill stress test and showed signs of decreased blood flow to the heart also had changes in five metabolites in their blood within two hours.
A control group of patients with normal stress tests did not show the same metabolite changes.
All study subjects had gone to the emergency department with symptoms of coronary disease, such as chest, jaw and shoulder pain.
The researchers hope a larger study could confirm that acute changes in these fatty acid and amino acid metabolites, which are energy sources for cells, could be an early biological indicator of restricted blood flow that could complement or even replace current tests.
“Cardiologists do a stress test to determine who’s at risk for having heart disease,” said lead author Alexander T. Limkakeng Jr., M.D., lead author of the study and an associate professor of emergency medicine at Duke. “It guides them on whether they need a more invasive study like a catheterization. Augmenting the imaging of a stress test with metabolite biomarkers could make that process more accurate or more efficient.”
Previous research has suggested that metabolites could indicate heart disease, but scientists have yet to uncover the specific metabolomic signature to look for. For the Duke study, scientists evaluated the presence of more than 60 chemicals or compounds in the blood to identify the five specific metabolites that appeared to change in patients with abnormal cardiac stress tests.
The researchers hope to begin a larger study to further test this approach to detecting coronary artery disease, they said.
Learn more: Blood Test for Specific Metabolites Could Reveal Blocked Arteries
The Latest on: Metabolite biomarkers
via Google News
The Latest on: Metabolite biomarkers
- Study Shows Simple Blood Test Could Detect Liver Injury Earlieron March 5, 2021 at 9:49 am
Dr. Jie Zheng and his colleagues described how gold nanoparticles may play a key role in a simple blood test to find acute liver damage earlier than current methods.
- The gut mycobiome of healthy mice is shaped by the environment and correlates with metabolic outcomes in response to dieton March 5, 2021 at 4:02 am
Tahliyah S. Mims et al. investigate the influence of the gut mycobiome abundance and composition on host metabolism. Using mice from four different commercial suppliers they find that the gut ...
- Hyocholic acid species as novel biomarkers for metabolic disorderson March 4, 2021 at 4:00 pm
The early identification of metabolic disorders could improve or prevent overt disease. Here the authors show that the circulating concentration of hyocholic acid (HCA) species is decreased in the ...
- Wave Life Sciences Ltd. (WVE) CEO Paul Bolno on Q4 2020 Results - Earnings Call Transcripton March 4, 2021 at 11:12 am
Q4 2020 Results Earnings Conference Call March 4, 2021, 08:00 AM ET Company Participants Kate Rausch - Head of Investor Relations Paul Bolno - ...
- Does a vegan diet lead to poorer bone health?on March 4, 2021 at 6:54 am
The vegan diet is on trend. How this type of diet affects health is the subject of scientific studies. In a new study from the German Federal Institute for Risk Assessment (BfR), the bone health of 36 ...
- Vegan diet affects bone health, shows studyon March 4, 2021 at 1:50 am
The vegan diet is on trend. How this type of diet affects health is the subject of scientific studies. In a new study from the German Federal Institute for Risk Assessment (BfR), the bone health of 36 ...
- Roswell Park Researchers Identify New Biomarker of Response to Checkpoint Inhibitorson March 3, 2021 at 10:35 am
Discovery in lung cancer could help determine which patients will benefit most from immunotherapy Durable responses to ...
- Longeveron Announces Successful Completion of Phase 2b Clinical Study of Lomecel-B Infusion to ...on March 2, 2021 at 9:32 pm
Trial funded in part by a National Institute on Aging Small Business Innovation Research (SBIR) Grant Trial objectives include evaluation of Lomecel-B’s effect on physical function, mobility, strength ...
- numares’ Novel GFR Equation Allows Accurate Assessment of Renal Insufficiency in Proof of Concepton February 26, 2021 at 12:34 am
Named GFR NMR, the test provided metabolic characterization of renal dysfunction, by evaluating a group of metabolites. This “metabolite constellation” was comprised of myo-inositol, dimethylsulfone, ...
- CrownBio and JSR Life Sciences Partner with Cambridge Quantum Computing to Leverage Quantum Machine Learning for Novel Cancer Treatment Biomarker Discoveryon February 24, 2021 at 10:15 am
JSR Life Sciences and Cambridge Quantum Computing (CQC) today announced a partnership agreement to explore the applicatio ...
via Bing News
