via Duke Medicine
Researchers hope to develop test that could detect early changes in blood flow to heart
A Duke Health pilot project suggests that in the near future, a blood test could show whether arteries carrying blood to the heart are narrow or blocked, a risk factor for heart disease.
According to the 40-person study published in the journal PLOS ONE, emergency patients who underwent a treadmill stress test and showed signs of decreased blood flow to the heart also had changes in five metabolites in their blood within two hours.
A control group of patients with normal stress tests did not show the same metabolite changes.
All study subjects had gone to the emergency department with symptoms of coronary disease, such as chest, jaw and shoulder pain.
The researchers hope a larger study could confirm that acute changes in these fatty acid and amino acid metabolites, which are energy sources for cells, could be an early biological indicator of restricted blood flow that could complement or even replace current tests.
“Cardiologists do a stress test to determine who’s at risk for having heart disease,” said lead author Alexander T. Limkakeng Jr., M.D., lead author of the study and an associate professor of emergency medicine at Duke. “It guides them on whether they need a more invasive study like a catheterization. Augmenting the imaging of a stress test with metabolite biomarkers could make that process more accurate or more efficient.”
Previous research has suggested that metabolites could indicate heart disease, but scientists have yet to uncover the specific metabolomic signature to look for. For the Duke study, scientists evaluated the presence of more than 60 chemicals or compounds in the blood to identify the five specific metabolites that appeared to change in patients with abnormal cardiac stress tests.
The researchers hope to begin a larger study to further test this approach to detecting coronary artery disease, they said.
Learn more: Blood Test for Specific Metabolites Could Reveal Blocked Arteries
The Latest on: Metabolite biomarkers
via Google News
The Latest on: Metabolite biomarkers
- Lumbar Epidural Steroid Jab Lowers Bone Formation in Older Womenon October 15, 2021 at 3:38 am
The extent and duration of the effects of a lumbar epidural steroid injection suggest that patients who receive multiple injections may be at particular risk for skeletal problems.
- Kaneka’s gut-brain axis probiotic is now self-affirmed GRASon October 14, 2021 at 5:46 am
Kaneka has announced that its Lactobacillus plantarum DR7 probiotic, designed to support the gut-brain axis, is now self-affirmed GRAS.
- Anatomic Pathology Market Growth Driven by Growing Use of Biomarkers in Cancer Diagnosis: Reports and Dataon October 13, 2021 at 11:11 pm
Increasing incidence of cancer and tumorigenesis worldwide and surging need for personalized medicine are among the major factors driving the global market growth According to Reports and Data, the ...
- MiRxes Looks to Expand miRNA Assay Technology to Multiple Cancer Types, Other Disease Areason October 13, 2021 at 7:20 am
The firm said it has long-term plans to launch multiple miRNA screening tests for cancers that would run in labs or at the point of care using one blood sample.
- Options Available in Second Line for Patients With TNBC and No Biomarkerson October 13, 2021 at 3:00 am
Eight months after completion of adjuvant therapy for triple-negative breast cancer, a 48-year-old patient reported worsening fatigue.
- Tirzepatide Improves CVD Risk Biomarkers in Patients With diabetes: Studyon October 11, 2021 at 9:00 pm
Tirzepatide use is associated with a reduction in several biomarkers associated with cardiovascular risk, suggests a study published in the Diabetes, Obesity and Metabolism.
- Researchers identify new biomarker for severe COVID-19on October 8, 2021 at 9:47 pm
During the pandemic, it has become increasingly evident that people with cardiovascular disease and obesity are at a much higher risk of developing very severe, even fatal COVID-19 disease.
- New biomarker for severe COVID-19on October 8, 2021 at 4:18 am
During the pandemic, it has become evident that people with cardiovascular disease and obesity are at much higher risk of developing very severe, even fatal COVID-19 disease. Researchers at Karolinska ...
- Localized stage II/III periodontitis risk varies with metabolic biomarkers in young adults: Studyon October 7, 2021 at 8:30 pm
The risk of localized stage II/III periodontitis may vary with metabolic components in young adults, according to a study published in the Journal of Periodontology. Periodontitis, also ...
via Bing News
