DGIST’s research Team has clarified the fundamentals of coiled toxin protein which causes neurodegenerative brain disorders
A research team led by Professor Sung Bae Lee of Brain and Cognitive Sciences and Professor Daehee Hwang of New Biology (Vice-head of the Plant Age and Life Research Group, IBS) has identified the early neuropathology mechanism of structural characteristics of polyglutamine toxic protein on neurodegenerative brain disorders. It was through a joint research with Professor Yuh Nung Jan at the Howards Hughes Medical Institute (HHMI) in the U.S.
The number of patients with neurodegenerative disorders is growing rapidly as humans’ life expectancy is increasing. Although many scholars are devoted into researching the pathogenesis and the advancement of neurodegenerative brain disorders, not much has been identified yet. There is still too much work left to develop an actual treatment since it is difficult to diagnose the disease early.
In this study, the researchers identified that coiled-coil structure of polyglutamine toxic protein, which is like an entangled telephone wire, causes the rapid deformation of neuron and early neurodegenerative diseases, such as Huntington’s chorea and spino-cerebellar ataxias.
Proteins have abnormal combinations with each other to form the coiled-coil structure of polyglutamine toxic protein. The research team discovered that the coiled-coil structure of polyglutamine toxic protein inside neurons cause early neuropathy by combining with ‘Foxo protein’, which is adjusts the formation of dendrite, as a transcription factor.
While the research focused on Foxo protein as the first factor of the early symptom of neurodegenerative brain disorders, it also predicted that other factors would exist. The research team thus expected to be able to speed the related studies in the future by focusing on clarifying additional factors based on this research.
Professor Lee said “The core of this research is that the coiled-coil structure of toxin protein that causes degenerative brain disorders entangle with the coiled-coil structure of other protein, which is an important cause of early neurodegenerative diseases. By developing a treatment targeting the entanglement based on coiled-coil structure through this research, we expect to be able to have effective treatments to alleviate the early symptoms of neurodegenerative brain disorders”
Learn more: A New Hope in Treating Neurodegenerative Disease
The Latest on: Neurodegenerative brain disorders
via Google News
The Latest on: Neurodegenerative brain disorders
- New Brunswick opens clinic for patients with mysterious brain diseaseon April 30, 2021 at 12:27 pm
Symptoms of the unknown neurological disorder include rapidly progressing dementia, muscle spasms and atrophy.
- New Brunswick opens clinic for patients suffering from mysterious brain diseaseon April 30, 2021 at 5:14 am
The Horizon Health Network announced Thursday it opened the Special Neurodegenerative Disorder Clinic for patients with rapid or early-onset cognitive decline ...
- Deciphering link between Iron and Brain Diseaseon April 30, 2021 at 3:36 am
Aceruloplasminemia is a very rare, genetic disease accompagnied with iron accumulation that causes movement disorder and brain damage at early age.
- Red Sparrow Author Jason Matthews Dead at 69 from Rare Neurodegenerative Disease: 'A Sad Loss'on April 29, 2021 at 2:02 pm
Jason Matthews, the award-winning writer of the Red Sparrow series, has died at the age of 69. The author died on Wednesday from corticobasal degeneration, a rare disease that affects the brain and ...
- An In Vitro Model of the Gut-Liver-Brain Axis for Studying Neurodegenerative Diseaseson April 29, 2021 at 12:22 pm
Researchers modelled the interactions between three different organ systems with relevance to neurodegenerative disease pathology, the gut, liver, and brain, by connecting microphysiological systems ...
- Annovis Bio to Study Potential of ANVS401 to Normalize Brain Development in Down Syndromeon April 29, 2021 at 4:00 am
Annovis Bio Inc., a clinical-stage drug platform company addressing Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases, today announced a new research collaboration with ...
- Could unclogging the brain's drainage system improve the efficacy of Biogen's aducanumab in Alzheimer's?on April 28, 2021 at 8:00 am
Scientists have proposed a possible explanation for the disappointing clinical trial results from Biogen's anti-amyloid Alzheimer's drug aducanumab. The team pointed to the brain’s newly discovered ...
- Parkinson's Disease is neurodegenerative and incurable, but treatableon April 26, 2021 at 2:00 pm
April is the month to bring awareness to Parkinson’s Disease, a disorder of the central nervous system that affects movement.
- New Drug Boosts Brain Cell Cleanup to Combat Neurodegenerative Diseaseson April 23, 2021 at 10:26 am
When the ‘garbage trucks’ of the brain slow down and stop with age, particularly in neurodegenerative diseases like Alzheimer’s, the trash piles up. Alzheimer’s and all other neurodegenerative ...
- Novel Sleep Biomarkers Linked to Neurodegenerative Diseaseon April 20, 2021 at 10:00 am
Advanced Brain Monitoring, Inc. announces the discovery of two novel sleep biomarkers linked to neurodegenerative disease at the annual meeting of the ...
via Bing News