Dr. Paul Harch, Clinical Professor and Director of Hyperbaric Medicine at LSU Health New Orleans School of Medicine, and Dr. Edward Fogarty, Chairman of Radiology at the University of North Dakota School of Medicine, report the first PET scan-documented case of improvement in brain metabolism in Alzheimer’s disease in a patient treated with hyperbaric oxygen therapy (HBOT).
The report, published in the current issue of the peer-reviewed journal Medical Gas Research, is available here.
The authors report the case of a 58-year-old female who had experienced five years of cognitive decline, which began accelerating rapidly. Single photon emission computed tomography (SPECT) suggested Alzheimer’s disease. The diagnosis was confirmed by 18Fluorodeoxyglucose (18FDG) positron emission tomography (PET) brain imaging, which revealed global and typical metabolic deficits in Alzheimer’s.
The patient underwent a total of 40 HBOT treatments – five days a week over 66 days. Each treatment consisted of 1.15 atmosphere absolute/50 minutes total treatment time. After 21 treatments, the patient reported increased energy and level of activity, better mood and ability to perform daily living activities as well as work crossword puzzles. After 40 treatments, she reported increased memory and concentration, sleep, conversation, appetite, ability to use the computer, more good days (5/7) than bad days, resolved anxiety, and decreased disorientation and frustration. Tremor, deep knee bend, tandem gain, and motor speed were also improved. Repeat 18FDG PET imaging one month post-HBOT showed global 6.5–38% improvement in brain metabolism.
“We demonstrated the largest improvement in brain metabolism of any therapy for Alzheimer’s disease,” notes Dr. Harch. “HBOT in this patient may be the first treatment not only to halt, but temporarily reverse disease progression in Alzheimer’s disease.”
The report also contains video imaging, including unique rotating PET 3D Surface Reconstructions, which allow the lay person to easily see the improvements in brain function.
“PET imaging is used around the world as a biomarker in oncology and cardiology to assay responses to therapy,” says Dr. Fogarty. “We now have an irrefutable biomarker system that this intervention has promise where no other real hope for recovery of dementia has ever existed before.”
The physicians report that two months post-HBOT, the patient felt a recurrence in her symptoms. She was retreated over the next 20 months with 56 HBOTs (total 96) at the same dose, supplemental oxygen, and medications with stability of her symptoms and Folstein Mini-Mental Status exam.
According to the National Institutes of Health, “Alzheimer’s disease is an irreversible, progressive brain disorder that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks. It is the most common cause of dementia in older adults. Alzheimer’s disease is currently ranked as the sixth leading cause of death in the United States, but recent estimates indicate that the disorder may rank third, just behind heart disease and cancer, as a cause of death for older people.”
The authors note that four pathological processes have been identified and primary treatment is with acetylcholinesterase inhibitors or the N-methyl-D-aspartate receptor antagonist memantine, which have been shown to have a positive impact on Alzheimer’s disease progression with no significant disease-modifying effects.
HBOT is an epigenetic modulation of gene expression and suppression to treat wounds and disease pathophysiology, particularly inflammation. HBOT targets all four of the pathological processes of AD by affecting the microcirculation; mitochondrial dysfunction, and biogenesis; reducing amyloid burden and tau phosphorylation; controlling oxidative stress; and reducing inflammation.
The first successful HBOT-treated case of Alzheimer’s disease was published in 2001. The present case report is the first patient in a series of 11 HBOT-treated patients with Alzheimer’s disease whose symptomatic improvement is documented with 18fluorodeoxyglucose positron emission tomography (18FDG PET).“Our results suggest the possibility of treating Alzheimer’s disease long-term with HBOT and pharmacotherapy,” concludes Harch.
Learn more: HBOT Showed Improvement in Alzheimer’s Disease
The Latest on: Hyperbaric oxygen therapy
via Google News
The Latest on: Hyperbaric oxygen therapy
- Baystate Health closing wound care unit at Mary Lane Outpatient Center in Wareon January 22, 2021 at 2:26 am
The Springfield-based health care provider said the decision was “due to lack of demand” at the Ware facility.
- “Holy Grail” – Hyperbaric Oxygen Treatments Reverse Aging Process in First Clinical Trialon January 19, 2021 at 9:08 am
Study finds hyperbaric oxygen treatments halt the aging of blood cells and reverses the aging process. A new study from Tel Aviv University (TAU) and the Shamir Medical Center in Israel indicates that ...
- Alfred Hospital reviews case after telling Lavington resident he couldn't come, being from NSWon January 12, 2021 at 11:35 pm
A Lavington resident has successfully pleaded his case to the Alfred Hospital in Melbourne after being told he'd have to go to Sydney for treatment because he lived in NSW. Peter Elkins was contacted ...
- Mental health care needed in pandemicon January 12, 2021 at 12:24 pm
Mental wellness, and licensed cognitive behavioral therapist, Crystal Clark joins Gayle Guyardo on Bloom to talk about the importance of mental health care during the pandemic.
- Hyperbaric medicine now being used for anti-agingon January 12, 2021 at 12:22 pm
There is some incredible research going on in the Tampa Bay Area with hyperbaric oxygen therapy, that includes cognitive enhancement, and anti-aging at the cellular level. Hyperbaric medical ...
- EXCLUSIVE: Strangest Photo Ever Of Michael Jacksonon January 10, 2021 at 4:00 pm
Jackson later denied that report. Hyperbaric chambers are used for hyperbaric oxygen therapy and treat the body with 100 percent oxygen at greater than normal pressure. The chamber is used in ...
- Global Oxygen Therapy Devices Market Analysis and Forecast Model to 2030 with Coverage of 39 Country Marketson January 4, 2021 at 11:47 pm
The model discusses in detail the impact of COVID-19 on Oxygen Therapy Devices market for the year 2020 and beyond. Hyperbaric Oxygen Therapy (HBOT) is prescribed by medical professionals to treat ...
- From aging to chronic wounds, is hyperbaric oxygen a cure-all?on January 4, 2021 at 11:16 pm
It’s easy to see why Prof. Shai Efrati has been flooded with inquiries since the publication of his study showing that hyperbaric oxygen therapy (HBOT) can reverse aging at the cellular level. Is this ...
- Coronavirus and heavy winds: A tumultuous year in Greenwich — and everywhereon December 31, 2020 at 4:55 pm
Thursday, Nov. 5, 2020. Greenwich Hospital will be taking part in a year-long trial that will examine treatment for COVID-19 through the use of hyperbaric oxygen therapy. Coronavirus and heavy ...
- How is hyperbaric oxygen therapy administered for carbon monoxide (CO) toxicity?on December 30, 2020 at 4:00 pm
4:CD002041. [Medline]. Han S, Nah S, Choi S, Lee YH, Kim GW, Cho YS. Hyperbaric Oxygen Therapy Did Not Prevent Delayed Neuropsychiatric Sequelae in a Prospective Observational Study With ...
via Bing News