In a University of California, Irvine-led study, researchers found evidence that fasting affects circadian clocks in the liver and skeletal muscle, causing them to rewire their metabolism, which can ultimately lead to improved health and protection against aging-associated diseases.
The study was published recently in Cell Reports.
The circadian clock operates within the body and its organs as intrinsic time-keeping machinery to preserve homeostasis in response to the changing environment. And, while food is known to influence clocks in peripheral tissues, it was unclear, until now, how the lack of food influences clock function and ultimately affects the body.
“We discovered fasting influences the circadian clock and fasting-driven cellular responses, which together work to achieve fasting-specific temporal gene regulation,” said lead author Paolo Sassone-Corsi, Donald Bren Professor of Biological Chemistry at UCI’s School of Medicine. “Skeletal muscle, for example, appears to be twice as responsive to fasting as the liver.”
The research was conducted using mice, which were subjected to 24-hour periods of fasting. While fasting, researchers noted the mice exhibited a reduction in oxygen consumption (VO2), respiratory exchange ratio (RER), and energy expenditure, all of which were completely abolished by refeeding, which parallels results observed in humans.
“The reorganization of gene regulation by fasting could prime the genome to a more permissive state to anticipate upcoming food intake and thereby drive a new rhythmic cycle of gene expression. In other words, fasting is able to essentially reprogram a variety of cellular responses. Therefore, optimal fasting in a timed manner would be strategic to positively affect cellular functions and ultimately benefitting health and protecting against aging-associated diseases.”
This study opens new avenues of investigation that could ultimately lead to the development of nutritional strategies to improve health in humans.
Sassone-Corsi first showed the circadian rhythm-metabolism link some 10 years ago, identifying the metabolic pathways through which circadian proteins sense energy levels in cells.
The Latest on: Fasting
via Google News
The Latest on: Fasting
- Rejuvenate your body and mind with these fasting tips for Navratrion October 13, 2021 at 5:19 am
What can be better than detoxifying your body and increasing positivity at the same time? Fasting has the power to do both. Navratri has come, so ...
- Want to Lose Weight? Try Intermittent Fasting For Weight Loss, Says Studyon October 13, 2021 at 4:33 am
According to a recent study, intermittent fasting can help in significant weight loss and can also improve your metabolic health.
- Intermittent fasting works for weight loss, health changes: Studyon October 13, 2021 at 12:00 am
A recent stidu siggesys that intermittent fasting can produce clinically significant weight loss as well as improve metabolic health in individuals with obesity.
- How one should modify their exercise regime and diet while fastingon October 12, 2021 at 10:41 pm
Navratri is being celebrated from October 7 to October 15 this year. While many Hindus fast during the nine-day festival, people fast around the year to detoxify their bodies and cut back on unwanted ...
- Navratri fast: Fasting like a boss and losing weight tooon October 12, 2021 at 9:15 am
The nine-day-long festival that accompanies a period of fasting incites happiness and rejoicing among everyone. This period of abstinence is aimed at renewing our spiritual energy.
- I Let Go Of Intermittent Fastingon October 12, 2021 at 6:00 am
One writer considered intermittent fasting a real linchpin for their life, but realized they may have been wrong.
- Research review shows intermittent fasting works for weight loss, health changeson October 12, 2021 at 5:20 am
Intermittent fasting can produce clinically significant weight loss as well as improve metabolic health in individuals with obesity, according to a new study review led by University of Illinois ...
- Want a Better Memory? Neuroscience Says Intermittent Fasting Might Hold the Keyon October 11, 2021 at 9:02 pm
I'm kidding; I remember the third one, but it's a bit meta, and we're better off saving it for the end anyway. So, let's go to the study. It comes to us from King's College London, where researchers ...
- The Full-Body Benefits of Intermittent Fasting, from Weight Loss to Immunityon October 11, 2021 at 11:29 am
Maybe you’ve tried intermittent fasting (IF) to shed a few (pandemic!) pounds, since the hope and potential for weight loss is what this eating plan is best known for. And yes, scientists are looking ...
- Can Intermittent Fasting Really Help You Lose Weight and Live Longer?on October 11, 2021 at 11:29 am
What science says about how intermittent fasting or time-restricted eating may boost immunity, reduce inflammation, increase longevity, and support weight loss.
via Bing News