A new mechanism for activating the immune system against cancer cells allows immune cells to detect and destroy cancer cells better than before, according to a study published this week in the journal Nature.
The study was led by Prof. Nick Haining, of Harvard Medical School, and co-authored by Prof. Erez Levanon, doctoral student Ilana Buchumansky, of the Mina and Everard Goodman Faculty of Life Sciences at Bar-Ilan University, and an international team.
The focus of the study is a mechanism that routinely serves the cell by marking human virus-like genes in order to avoid identifying them as viruses. Now, Prof. Levanon, together with the Harvard team, has discovered that when inhibiting this mechanism, the immune system can be harnessed to fight cancer cells in a particularly efficient manner, and most effectively in lung cancer and melanoma.
“We found that if the mechanism is blocked, the immune system is much more sensitive. When the mechanism is deactivated, the immune system becomes much more aggressive against the tumor cells,” said Levanon.
In recent years, a new generation of cancer drugs has been developed which blocks proteins that inhibit immune activity against malignant tumors. These drugs have shown remarkable success in several tumor types. This year’s Nobel Prize in Medicine was awarded to James Allison and Tasuku Honjo, who discovered the key genes of this mechanism. Despite this achievement, the current generation of drugs helps only a small number of patients, while most of the drugs fail to cause the immune system to attack the tumor. It is hoped that the new discovery will allow enhanced activity of the immune system to attack cancer cells. A number of companies have already begun research to screen for drugs that will operate on the basis of this discovery.
The Latest on: Immune system
[google_news title=”” keyword=”immune system” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Immune system
- New findings on the immune systemon February 29, 2024 at 4:00 pm
T follicular helper cells (Tfh) are essential for strong antibody-mediated reactions of our immune system during infections and vaccinations. However, if they get out of control, this can cause ...
- How Walking Can Boost Your Immune Systemon February 29, 2024 at 11:24 am
Having a strong immune system is your best defense against infections and disease. Your immune system protects you from germs, destroys harmful substances that get into your body, heals any body ...
- The Intersection of Mental Health and the Immune Systemon February 28, 2024 at 12:09 pm
The current mental health crisis is showing no signs of abating. Suicide rates continue to rise, reaching the highest they have been in U.S. history. 1 Chronic absenteeism has doubled in elementary ...
- How early-stage cancer cells hide from the immune systemon February 28, 2024 at 8:00 am
One of the immune system's primary roles is to detect and kill cells that have acquired cancerous mutations. However, some early-stage cancer cells manage to evade this surveillance and develop into ...
- The 'switch' that keeps the immune system from attacking the bodyon February 28, 2024 at 8:00 am
A microscopic battle rages in our bodies, as our cells constantly fend off invaders through our immune system: a complex system of cells and proteins designed to protect us from harmful pathogens. One ...
- 7 natural ways to boost your immune systemon February 28, 2024 at 7:15 am
In today’s fast-paced world, maintaining a strong immune system is crucial for overall health and well-being. A robust immune system not only helps you fight off illnesses but also plays a key role in ...
- Taming the Immune System When Rare Diseases Strikeon February 27, 2024 at 10:16 am
Therapies for rare autoimmune diseases are progressing with an enhanced understanding of how the immune system misfires to cause cell, tissue, and organ damage.
- Best Apple Cider Vinegar Drinks to Keep Your Gut and Immune System Hummingon February 27, 2024 at 6:16 am
If you want the healthy benefits of apple cider vinegar without the harsh taste, these delicious ACV-based drinks will have you slugging it all season.
- Females' immune system edges out males but at a cost of higher autoimmune riskon February 22, 2024 at 8:30 pm
A review article highlights how two X chromosomes in females influence immune system composition and function, leading to faster infection clearance and stronger vaccination responses but also a ...
- Overproduction of immune system protein may be biomarker of long COVIDon February 22, 2024 at 7:19 am
Infection with the COVID-19 virus triggers the production of an immune system protein that's long been associated with fatigue, muscle ache and depression.
via Bing News