Inkjet-printed device helps monitor a patient’s blood sugar levels without painful needles.
A technique that enables biologically active enzymes to survive the rigors of inkjet printing presents a promising alternative to routine blood screening exams faced by diabetic patients. The KAUST-led team used this approach to make disposable devices that can measure glucose concentrations in human saliva.
Strips of pH-sensitive paper are commonly used to test whether a liquid is acidic or alkaline. Researchers are now working to apply similar principles to create paper sensors that quickly indicate disease biomarkers. Key to this approach is replacing traditional electronic circuitry in the sensors with low-cost plastics that can be manufactured quickly and in large quantities.
Bioscientist Sahika Inal collaborated with electrical engineer Khaled Salama and materials scientist Derya Baran to use inkjet technology to produce sensors sensitive to small sugar concentrations in biofluids.
Utilizing a commercial ink made from conducting polymers, the team printed microscale electrode patterns onto glossy paper sheets. Next, they printed a sensing layer containing an enzyme, glucose oxidase, on top of the tiny electrodes. The biochemical reaction between available glucose and the enzyme creates electrical signals easily correlated to blood sugar levels.
“Paper is porous, which makes it challenging to print conducting and biological inks that are dissolved in water,” says Eloise Bihar, a postdoctoral researcher at KAUST and the first author of the study. “Printing the enzyme is tricky as well—it’s sensitive to variations of temperature, the voltage applied at the cartridge, and the pH of the ink.”
After optimizing the enzyme-printing conditions, the researchers had another obstacle to tackle. While fluids, such as sweat or saliva, contain enough sugar for monitoring purposes, they also contain molecules, such as ascorbic acid, that interfere electrically with conducting polymers. Coating the sensor with a nafion polymer membrane that repels the negative charges present in most interfering species enabled measurement of only the relevant glucose levels in saliva samples from volunteers.
Experiments showed the top coating gave the sensor an unprecedented shelf life—the enzyme could be kept alive and active for a month if stored in a sealed bag. These results are encouraging the team to expand the capabilities of this approach by incorporating different enzymes into the sensing layer.
“Optimization never ends in engineering, so we are trying to make this system more robust to detect other metabolites in biofluids,” says Inal. “We are also looking to integrate printed and self-powered energy devices into the sensors, giving us a more user-friendly platform that eliminates external batteries or wires.”
The Latest on: Paper sensors
via Google News
The Latest on: Paper sensors
- New Paper-based Sensor Helps Detect Antimicrobial Pollutantson May 4, 2021 at 10:10 am
The paper-based sensor detects antimicrobial pollutants, which induce antimicrobial resistance in water bodies.
- ‘Paper sensor’ developed by IIT Madras could help detect & monitor antimicrobial pollutantson May 4, 2021 at 8:00 am
Developed in collaboration with UK researchers, the low cost, paper-based sensor could help at deal with antimicrobial resistance that is becoming a worldwide health crisis.
- IIT Madras, UK Researchers Develop Paper-based Sensor To Detect AMR Triggering Pollutantson May 4, 2021 at 7:41 am
IIT Madras and U.K. Researchers have developed a Paper-based Sensor to detect Antimicrobial Resistance triggering Pollutants.
- Novel paper-based sensor to detect antimicrobial pollutantson May 4, 2021 at 6:51 am
Researchers at the Indian Institute of Technology Madras (IITM) have developed a paper-based sensor that can detect antimicrobial pollutants, which induce antimicrobial resistance in water bodies.
- IIT Madras, UK researchers develop sensor to detect antimicrobial resistance triggering pollutantson May 4, 2021 at 4:29 am
The research behind the developed sensor has been published in Nature Scientific Reports Journal and has been acknowledged as one of the top 100 in ch..
- IIT-M, UK researchers develop paper-based sensor to detect AMRon May 4, 2021 at 3:47 am
Researchers at the Indian Institute of Technology-Madras and hailing from the United Kingdom have developed a paper-based sensor that can detect antimicrobial pollutants which induce antimicrobial ...
- IIT Madras, UK Researchers Develop Sensors To Detect Antimicrobial Pollutantson May 4, 2021 at 2:36 am
Madras along with a group of UK-based researchers have developed paper-based sensors that can detect antimicrobial resistance-triggering pollutants.
- IIT Madras and U.K. Researchers Develop Paper-based Sensor to detect Antimicrobial Resistance triggering Pollutantson May 4, 2021 at 2:03 am
Chennai: Indian Institute of Technology Madras and United Kingdom Researchers have developed a paper-based sensor that can detect antimicrobial pollutants, which induce antimicrobial resistance in ...
- I2C Paper Tape Reader Is Not What You Thinkon May 3, 2021 at 8:31 am
We’re not quite sure what drove the development of this project, but [shapoco] has put together an intriguing device that reads I2C signals (Japanese Twitter link) which have been printed as ...
- Research on improved evidence theory based on multi-sensor information fusionon April 29, 2021 at 6:02 am
In view of the lack of effective information fusion model for heterogeneous multi-sensor, an improved Dempster/Shafer (DS) evidence theory algorithm is designed to fuse heterogeneous multi-sensor ...
via Bing News