University of Alberta scientists find a new application for an existing drug, with potential to slow progression of the devastating degenerative disease.
A new drug could significantly slow the progression of ALS, also known as Lou Gehrig’s disease, according to new research by University of Alberta biologists. Current treatments slow progression of the degenerative disease by only a few months, and these findings could revolutionize the treatment of patients suffering from ALS, extending and improving quality of life.
The drug, called telbivudine, targets a protein that misfolds and does not function correctly in patients with ALS. “SOD1 is a protein that is known to misfold and misbehave in most cases of patients with ALS,” explained Ted Allison, associate professor in the Department of Biological Sciences and co-author on the study. “We showed that telbivudine can greatly reduce the toxic properties of SOD1, including improving the health of the subject’s motor neurons and improving movement.”
The research team used computer simulations to identify drugs with the potential for targeting the SOD1 protein. From this shortlist, the scientists identified and tested the most likely candidates—including telbivudine—using animal models.
“ALS is not well-understood,” said lead author Michele DuVal, who recently completed the PhD portion of the Faculty of Medicine & Dentistry’sMD/PhD program under the supervision of Allison. “We don’t yet know exactly what goes wrong first in the motor neurons or how the misbehaving SOD1 causes toxicity. Because there is still much to learn about the disease, the ALS research community focuses on both understanding ALS and on developing promising therapies.”
The discovery of telbivudine as a potential treatment is particularly exciting because the drug is already in use for treating patients with hepatitis. “It is already proven safe to use in patients, and it has very good potential for repurposing to use in a new clinical setting against ALS,” said Allison.
The Latest on: Lou Gehrig’s disease
via Google News
The Latest on: Lou Gehrig’s disease
- Ales for ALS: Brewery joins fight against the disease with creative fundraiseron June 13, 2022 at 3:28 am
A portion of proceeds from the sale of the Manchester brewery's A Brief History of Hops will go toward ALS research efforts.
- Lou Gehrig Day special to Rockies' Sam Hilliard and familyon June 7, 2022 at 2:51 pm
It’s been 83 years since Lou Gehrig showed us his strength. The speech that rocked the baseball world, telling everybody that he would be retiring because of a disease that had no cure: amyotrophic ...
- A Redwood City biotechnology startup's treatment for Lou Gehrig's disease passed its first big teston June 3, 2022 at 3:24 pm
TranquisTx looks to push #ALS drug into Phase II study by end of year #BayArea #biotech #LouGehrigsDisease #SiliconValley #SanFrancisco ...
- Tommy Smith’s battle with Lou Gehrig’s diseaseon June 2, 2022 at 10:34 pm
Tommy Smith’s life changed when he was diagnosed with ALS, more commonly know as Lou Gehrig’s Disease. The diagnosis ultimately forced Smith to step away from the baseball field. “I wouldn’t wish this ...
- Baseball honors Gehrig while raising awareness of ALSon June 2, 2022 at 5:25 pm
Jim Poole describes the past year almost matter-of-factly, even though the effects of ALS on the former reliever are anything but. “I'm going to say a downhill spiral, but not in the negative sense. I ...
- Phillies continue mission to #StrikeOutALS on second annual Lou Gehrig Night at Friday's game against the Los Angeles Angelson June 2, 2022 at 2:18 pm
The Phillies are continuing their mission of raising awareness for ALS, the always-fatal neurodegenerative disease, at their ballpark-wide Lou Gehrig Night on Friday, June 3, with the goal of raising ...
- Yankees Aaron Boone, Aaron Judge honor Lou Gehrigon June 2, 2022 at 12:37 pm
New York Yankees skipper Aaron Boone wore an “End ALS 4 Lou” shirt. Aaron Judge had a pair of cleats that featured the famed Yankee on them. The tributes were part of a celebration of Gehrig across ...
- TSN Archives: How Lou Gehrig described his weakening condition, end of streak to The Sporting News in 1939on June 2, 2022 at 7:40 am
Lou Gehrig played what would be his final big-league game on April 30, 1939, at 35 years old. A few days later, the Yankees legend known throughout his playing days as “Laruppin’ Lou” sat down with ...
- Second annual Lou Gehrig Day on June 2ndon June 1, 2022 at 3:19 pm
Major League Baseball today announced the various activities that have been coordinated by MLB, its Clubs and the Lou Gehrig Day Committee to celebrate the second annual “Lou Gehrig Day” on Thursday, ...
- Lou Gehrig, First To Have Number Retired, Launched A Major Traditionon June 1, 2022 at 10:14 am
Lou Gehrig, unable to play because of ALS, received gifts and cheers from a packed Yankee Stadium on ... [+] July 4, 1939. As Major League Baseball marks Lou Gehrig Day on June 2, the tradition that ...
via Bing News