A new test for cervical cancer was found to detect all of the cancers in a randomised clinical screening trial of 15,744 women, outperforming both the current Pap smear and human papillomavirus (HPV) test at a reduced cost, according to a study led by Queen Mary University of London.
The study, published in the International Journal of Cancer, compared a new ‘epigenetics-based’ cervical cancer test with Pap smear and HPV tests, and investigated how well it predicted the development of cervical cancer up to five years in advance in a large study of women aged 25-65 in Canada.
As opposed to checking for patterns in the DNA genetic code itself that are indicative of the HPV virus, the new test looks at the naturally-occurring chemical markers that appear on top of the DNA, making up its ‘epigenetic profile’.
‘An enormous development’
Lead researcher Professor Attila Lorincz from Queen Mary’s Wolfson Institute of Preventive Medicine who also helped develop the world’s first test for HPV in 1988, said: “This is an enormous development. We’re not only astounded by how well this test detects cervical cancer, but it is the first time that anyone has proven the key role of epigenetics in the development of a major solid cancer using data from patients in the clinic. Epigenetic changes are what this cervical cancer test picks up and is exactly why it works so well.
“In contrast to what most researchers and clinicians are saying, we are seeing more and more evidence that it is in fact epigenetics, and not DNA mutations, that drives a whole range of early cancers, including cervical, anal, oropharyngeal, colon, and prostate.”
Screening to prevent cervical cancer is typically done through the Pap smear, which involves the collection, staining and microscopic examination of cells from the cervix. Unfortunately, the Pap smear can detect only around 50 per cent of cervical pre-cancers.
A much more accurate cervical screening method involves testing for the presence of DNA from the human papillomavirus (HPV) – the primary but indirect cause of cervical cancer. There are estimated to be around 10 million women in the UK who are infected by HPV.
However, the HPV test only identifies whether or not women are infected with a cancer-causing HPV, but not their actual risks of cancer, which remain quite low. This causes unnecessary worry for the majority of HPV-infected women who receive a positive result but will eventually clear the virus and not develop the disease.
Predicting a person’s risk of cervical cancer
The new test was significantly better than either the Pap smear or HPV test. It detected 100 per cent of the eight invasive cervical cancers that developed in the 15,744 women during the trial. In comparison, the Pap smear only detected 25 per cent of the cancers, and the HPV test detected 50 per cent.
The study also looked more closely at a subset of 257 HPV-positive women which were representatively selected from the large study. The new test detected 93 per cent of pre-cancerous lesions in those women, compared to 86 per cent detected using a combination of the Pap smear and HPV test, and 61 per cent detected using the Pap smear on its own.
Reducing the number of screening appointments needed
Professor Lorincz added: “This really is a huge advance in how to deal with HPV-infected women and men, numbering in the billions worldwide, and it is going to revolutionise screening.
“We were surprised by how well this new test can detect and predict early cervical cancers years in advance, with 100 per cent of cancers detected, including adenocarcinomas, which is a type of cervical cancer that is very difficult to detect. The new test is much better than anything offered in the UK at present but could take at least five years to be established.”
The authors say that using this test in the clinic would reduce the number of visits to the doctor and screening appointments, as high-grade disease would be detected from the start. They also say that if it was fully implemented, it would be cheaper than the Pap smear.
The Latest on: Cervical cancer
via Google News
The Latest on: Cervical cancer
- WHO pledges to support Kebbi State towards elimination of cervical cancer.on February 25, 2021 at 7:37 am
The World Health Organization is strengthening collaboration with the office of Kebbi State Governor’s wife to champion early cancer detection, improvement of the chances of successful treatment and ...
- Virus against virus: strategies for using adenovirus vectors in the treatment of HPV-induced cervical canceron February 25, 2021 at 6:56 am
Although most human papillomavirus (HPV) infections are harmless, persistent infection with high-risk types of HPV is known to be the leading cause of cervical cancer. Following the infection of the ...
- Understanding Cancer: Vital Tips to Safeguard Yourself From This Deadly Diseaseon February 24, 2021 at 7:27 pm
Dr Atul Narayankar, Consultant Medical Oncology, Wockhardt Hospital, Mira Road shares vital tips to safeguard yourself from Cancer.
- The deubiquitinase (DUB) USP13 promotes Mcl-1 stabilisation in cervical canceron February 24, 2021 at 3:31 am
For example, defects in ubiquitin-mediated proteasomal degradation can result in either the enhanced degradation of tumour suppressor proteins, or in the stabilisation of oncogenes [ 4 ].
- At-home smear tests to be trialled by thousands of UK women in bid to cut cervical cancer caseson February 24, 2021 at 3:21 am
Tens of thousands of women across the UK are trialling at-home smear tests in an effort to try and cut down the number of cervical cancer cases.
- Home smear tests trialled by NHS to encourage DIY cervical cancer screeningon February 24, 2021 at 3:20 am
Women aged 25-64 years who are 15 months overdue for a check and live in Barnet, Camden, Islington, Newham and Tower Hamlets will be contacted ...
- Thousands of women to trial at-home smear tests in bid to cut cervical canceron February 24, 2021 at 12:51 am
Many women don't come forward for the test due the 'embarrassment factor' and the problem has been exasperated by the pandemic.
- London women to be offered at-home smear test kits in NHS bid to cut cervical cancer rateson February 24, 2021 at 12:41 am
London are to trial at-home smear tests in a bid to cut the number of cervical cancers. More than 31,000 women will be given kits to carry out the tests in their own home, rather than having the test ...
- Scots mum, 32, devastated as she’s given a year to live after cervical cancer spread to lungson February 23, 2021 at 2:01 pm
A SCOTS mum is devastated as she was given a year to live after her cervical cancer spread to her lungs. Rachel Kennedy, 32, is raising funds for alternative treatments as she desperately hunts ...
- Cervical Cancer Treatment Market 2027 | Trends, Growth Overview, Development Size and Revenue Forecast | ARCon February 23, 2021 at 1:19 am
Global cervical cancer treatment market size is poised to reach around USD 11.2 bn by 2026, with registered 6.5% of CAGR during forecast period 2019 to 2026. The Cervical Cancer Treatment Market is ...
via Bing News