via The JAMA Network
New research published in the Journal of Physiology presents a breakthrough in the treatment of Restless Legs Syndrome (RLS).
RLS is a common condition of the nervous system that causes an overwhelming irresistible urge to move the legs. Patients complain of unpleasant symptoms such as tingling, burning and painful cramping sensations in the leg. More than 80% of people with RLS experience their legs jerking or twitching uncontrollably, usually at night.
Until now it was thought that RLS is caused by genetic, metabolic and central nervous system mechanisms. For the first time the researchers show that, in fact, it is not only the central nervous system but also the nerve cells targeting the muscles themselves that are responsible.
This new research indicates that the involuntary leg movements in RLS are caused by increased excitability of the nerve cells that supply the muscles in the leg, which results in an increased number of signals being sent between nerve cells.
Targeting the way messages are sent between nerve cells to reduce the number of messages to normal levels may help prevent the symptoms of RLS occurring. This could be achieved by new drugs that block the ion channels that are essential for the communication between nerve cells.
The research conducted by the University of Gottingen in conjunction with the University of Sydney and Vanderbilt University involved measuring the nerve excitability of motor nerve cells of patients suffering with RLS and healthy subjects.
The next step is to investigate the effect of different medications in patients and the effect on RLS.
Dirk Czesnik, corresponding author of the study, commented on the findings:
‘Patients who suffer from Restless legs syndrome complain of painful symptoms in the legs leading to sleep disturbances. The mechanisms for RLS are still not completely understood. We have shown that also the nerve cells supplying muscles in the leg are responsible and hereby additional drug treatments may be ahead targeting these nerve cells.’
Learn more: Breakthrough in treatment of restless legs syndrome
The Latest on: Restless legs syndrome
via Google News
The Latest on: Restless legs syndrome
- Restless Legs Syndromeon July 27, 2022 at 5:00 pm
It is not specific to restless legs syndrome (RLS). The International Restless Legs Syndrome scale is a 10-item scale with scores ranging from 0 (best) to 40 (worst). Items assess the intensity ...
- Placing a bar of soap under a bedsheet does not treat Restless Legs Syndromeon July 26, 2022 at 5:00 am
There is no scientific evidence or study that proves placing a bar of soap under a bedsheet can treat Restless Legs Syndrome ...
- Restless Legs Syndromeon July 24, 2022 at 5:00 pm
and options and guidelines for the treatment of restless legs syndrome (RLS) are reviewed. Summary: RLS was first described in the 17th century and further characterized in 1945. RLS is a common ...
- Comparison of Pregabalin with Pramipexole for Restless Legs Syndromeon July 20, 2022 at 5:00 pm
Dopaminergic medications relieve symptoms of the restless legs syndrome (RLS) but have the potential to cause iatrogenic worsening (augmentation) of RLS with long-term treatment. Pregabalin may be ...
- Is there a natural cure for restless legs syndrome?on July 16, 2022 at 5:00 pm
Restless legs is a syndrome characterised by uncomfortable tickling, burning, prickling or aching sensations in the muscles of the legs. Sufferers usually find that symptoms develop at night while ...
- Restless legs syndromeon June 14, 2022 at 9:56 am
For informational purposes only. Consult a medical professional for advice. Source: Focus Medica. A disorder that causes an overwhelming urge to move legs, usually associated with unpleasant ...
- Restless Leg Syndromeon April 30, 2022 at 8:24 pm
A team of Japanese researchers have found a rare 'Restless Anal Syndrome' post-Covid-19 recovery. This is the first time such a case has been associated with coronavirus disease. Restless legs ...
- Quiz on Restless Legs Syndrome (Advance)on April 5, 2022 at 7:56 am
Do you have an uncontrollable urge to move your legs? You may be suffering from Restless Legs Syndrome. Take the quiz and learn more about this disorder. View list of generic and brand names of ...
- Restless legs syndrome symptoms, self-help and treatmenton November 21, 2021 at 10:55 pm
When you’re suffering from restless legs syndrome you will feel an uncomfortable sensation on your legs with an irresistible urge to move. You will notice this happening more often in the ...
via Bing News
