New surfaces create promise of safer implants, more accurate diagnostic tests
Researchers at McMaster University have solved a vexing problem by engineering surface coatings that can repel everything, such as bacteria, viruses and living cells, but can be modified to permit beneficial exceptions.
The discovery holds significant promise for medical and other applications, making it possible for implants such as vascular grafts, replacement heart valves and artificial joints to bond to the body without risk of infection or blood clotting.
The new nanotechnology has the potential to greatly reduce false positives and negatives in medical tests by eliminating interference from non-target elements in blood and urine.
The research adds significant utility to completely repellent surfaces that have existed since 2011. Those surface coatings are useful for waterproofing phones and windshields, and repelling bacteria from food-preparation areas, for example, but have offered limited utility in medical applications where specific beneficial binding is required “It was a huge achievement to have completely repellent surfaces, but to maximize the benefits of such surfaces, we needed to create a selective door that would allow beneficial elements to bond with those surfaces,” explains Tohid DIdar of McMaster’s Department of Mechanical Engineering and School of Biomedical Engineering, the senior author of a paper that appears today in the journal ACS Nano.
In the case of a synthetic heart valve, for example, a repellent coating can prevent blood cells from sticking and forming clots, making it much safer.
“A coating that repels blood cells could potentially eliminate the need for medicines such as warfarin that are used after implants to cut the risk of clots,” says co-author Sara Imani, a McMaster PhD student in Biomedical Engineering.
Still, she explains, a completely repellent coating also prevents the body from integrating the new valve into the tissue of the heart itself.
By designing the surface to permit adhesion only with heart tissue cells, the researchers are making it possible for the body to integrate the new valve naturally, avoiding the complications of rejection. The same would be true for other implants, such as artificial joints and stents used to open blood vessels.
“If you want a device to perform better and not be rejected by the body, this is what you need to do,” says co-author Maryam Badv, also a McMaster PhD student in Biomedical Engineering. “It is a huge problem in medicine.”
Outside the body, selectively designed repellent surfaces could make diagnostic tests much more accurate by allowing only the particular target of a test – a virus, bacterium or cancer cell, for example – to stick to the biosensor that is looking for it, a critical advantage given the challenges of testing in complex fluids such as blood and urine.
The researchers, who collaborated with Jeffrey Weitz of the Thrombosis & Atherosclerosis Research Institute at Hamilton Health Sciences to understand the challenges related to making successful implants, are now working on the next stages of research to get their work into clinical use.
The Latest on: Smart surface
via Google News
The Latest on: Smart surface
- Smart wristband in China translates sign language into text, voice, imageson January 25, 2021 at 5:29 am
(Xinhua) -- An intelligent wristband capable of translating sign language into text, voice and images has debuted in northeast China's Liaoning Province. The watch-sized wristband captures the arm ...
- DRDO conducts successful flight test of Smart Anti Airfield Weaponon January 25, 2021 at 5:22 am
Defence Research and Development Organisation (DRDO) on Friday successfully conducted captive and release trial of indigenously developed Smart Anti-Airfield Weapon (SAAW). The smart weapon was ...
- University of Liverpool awarded grants to create anti-viral surface technologies to break chain of COVID transmissionon January 25, 2021 at 4:00 am
University of Liverpool announces that its has joined a consortium to develop new anti-viral technology that will limit the transmission of SARS-CoV-2 (Covid-19) from touching contaminated surfaces in ...
- DRDO's Smart Anti Airfield Weapon: Specifications of SAAW explainedon January 25, 2021 at 3:50 am
Smart Anti-Airfield Weapon (SAAW) has been transferred successfully by DRDO. Take a look at the specifications listed below.
- Luna and Zipp Mobility roll out smart scooterson January 25, 2021 at 3:28 am
Smart scooter technology company Luna and Zipp Mobility have begun rolling out next-generation scooters that ‘know’ where and how they are being parked and ridden. The announcement comes on the back ...
- Microsoft compares Surface Pro 7 to M1 MacBook Pro in an ad that falls aparton January 23, 2021 at 11:43 pm
Some things never change, including Microsoft's marketing skills. The company has put out a new Surface Pro 7 ad in which it tries to compare it against no an ...
- Best sleep gadgets of 2021: Drift away with smart sleeping masks, white noise machines, and moreon January 22, 2021 at 11:40 am
Humans spend about one-third of their lives asleep--or at least we are supposed to. These sleep gadgets are designed to help people drift to sleep, stay asleep, and wake refreshed.
- Jay Williams Chuckles At Marcus Smart’s Baffling Joel Embiid Commentson January 21, 2021 at 8:42 am
Jay Williams couldn't help but laugh at Marcus Smart's comments about Joel Embiid after the Boston Celtics' loss to the Philadelphia 76ers.
- Microsoft Launcher updates on Android with new features for Surface Duo and other smartphoneson January 21, 2021 at 12:28 am
The Microsoft Launcher app updated to Version 6.2.201202.93346 recently. This latest update added a number of new features for Surface Duo dual-screen smartphones such as drag-and-drop and two-app ...
via Bing News