via Phys.org
While stem cells have the most therapeutic potential, the benefits of regenerative medicine may best be mobilised using extracellular vesicles (EVs), also known in the past as “cellular dust”.
A team of researchers from CNRS, AP-HP, INSERM and Paris Descartes and Paris Diderot Universities have tested these vesicles for the first time in a porcine model for the treatment of post-operative digestive fistulas. Their results, which yielded a 100% success rate and appear in the 23 October 2018 edition of ACS Nano, open the door to testing in humans and broader possibilities for applications.
Extracellular vesicles are matter that is released by cells. Seen for many years as not having any value, this ‘cellular dust’ has been studied and presents therapeutic properties similar to their mother cells, without their disadvantages: These vesicles do not divide, limiting the risk of cancer, and do not differentiate either, thus preventing the development of poor function. Furthermore, it appears that they can be produced by a single donor for several patients, and have already demonstrated their therapeutic potential in animals in repairing heart, liver and kidney lesions.
In the case of digestive fistula, in which there is abnormal communication between organs in the digestive tract or with the skin, regenerative medicine is an important therapeutic avenue to explore. Fistulas of this kind respond poorly to current treatments; they can develop following post-operative complications or an auto-immune disorders such as Crohn’s disease, which causes digestive tract dysfunction.
For the first time, scientists at the Matières et systèmes complexes Lab (CNRS/Université Paris Diderot), the Gastroenterology and Endoscopy Department at the Hôpital Européen Georges Pompidou (HEGP) AP-HP and the Laboratoire Imagerie de l’angiogénèse, plateforme d’imagerie du petit animal (INSERM/Université Paris Descartes/HEGP)1, used extracellular vesicles from stem cells to treat digestive fistula in a swine model. The study reveals that local injections into the fistula of a gel containing these vesicles results in the complete closure of post-operative digestive fistula.
Researchers intend to test the new approach in a perineal fistula model found in Crohn’s disease, with the hope of replacing the stem cell injections. The vesicle gel could be administered locally and easily and become a simpler, safer and more effective treatment.
Learn more: “Cellular dust” provides new hope for regenerative medicine
The Latest on: Extracellular vesicles
[google_news title=”” keyword=”extracellular vesicles” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Extracellular vesicles
- Do you know cancers in distant organs change liver function? Study findson May 27, 2023 at 11:10 pm
In the study, which was published in Nature, the researchers discovered that extracellular vesicles and particles (EVPs) containing fatty acids secreted by a wide range of tumour types that are ...
- Europe Circulating Biomarkers and Extracellular Vesicles Annual Conference 2023 (Rotterdam, Netherlands - June 19-20, 2023)on May 26, 2023 at 3:00 am
Circulating Biomarkers and Extracellular Vesicles Europe 2023" conference has been added to ResearchAndMarkets.com's offering.
- Cancers in Far-Off Organs Can Alter Liver Functionon May 26, 2023 at 12:44 am
Cancers often release molecules into the bloodstream that pathologically alter the liver, shifting it to an inflammatory state, causing fat buildup and impairing its normal detoxifying functions.
- How cancers in distant organs change liver function: Studyon May 25, 2023 at 10:43 pm
The study explores how cancer can release molecules in the bloodstream, that modify the liver, further disrupting the detoxification processes.
- Study reveals how cancers in distant organs change liver functionon May 25, 2023 at 9:01 pm
Researchers at Weill Cornell Medicine found that cancer often releases molecules into the bloodstream that pathologically modify the liver sending it into an i ...
- Tumors in distant organs remotely reprogram the liveron May 25, 2023 at 7:57 pm
Cancers often release molecules into the bloodstream that pathologically alter the liver, shifting it to an inflammatory state, causing fat buildup and impairing its normal detoxifying functions, ...
- Researchers continue studies of extracellular vesicles for injury rehabilitation in animalson May 25, 2023 at 4:28 am
Science X is a network of high quality websites with most complete and comprehensive daily coverage of the full sweep of science, technology, and medicine news ...
- Cancers in distant organs alter liver functionon May 24, 2023 at 5:00 pm
Cancers often release molecules into the bloodstream that pathologically alter the liver, shifting it to an inflammatory state, causing fat buildup and impairing its normal detoxifying functions, ...
- Amyloid Jungle: Plaque Fibrils Mesh With All Manner of Vesicles, Membraneson May 24, 2023 at 12:14 pm
It reminds us that the amyloid plaque is not simply an inert ball of fibrils—it is a dynamic structure with many pathologic cellular events happening within and nearby,” wrote Dennis Selkoe and Andrew ...
via Bing News
