This eye disease often leads to blindness — which might be prevented by early intervention
The team headed by Dr. Jacqueline Reinhard and Prof. Dr. Andreas Faissner from the Department of Cell Morphology and Molecular Neurobiology in Bochum, together with colleagues from the University Eye Clinic in Bochum, RWTH Aachen University, the University of Toronto and the University of Denver, has published a report on their findings. The article was released on 12 October 2018 in the online edition of the journal Molecular Neurobiology.
Specific and early intervention
The researchers bred mice in which the gene PTP-Meg2 (protein tyrosine phosphatase megakaryocyte 2) was mutated . As a result, the animals suffered from chronic intraocular pressure elevation. The team successfully demonstrated that, in their model, the intraocular pressure elevation was associated with a loss of optic nerve fibres and retinal cells. Using functional analyses, they observed that retinal cells were unable to function properly, either. Moreover, they made the following discovery: glial cells and certain components of the immune system showed a reaction in the animals’ optic nerve and retina. As both aspects may be relevant for neurodegeneration, specific and early intervention into these cellular mechanisms may inhibit glaucoma.
Testing new therapy options
Making use of a genetic screening, the researchers subsequently identified new potential biomarkers. In future, these biomarkers may facilitate early detection of glaucoma; as a result, it will be possible to start therapy at an early stage, before the optic nerve and retina are damaged. The glaucoma-mouse model may, moreover, be used to test new therapy options. Experiments to date have shown that intraocular pressure was reduced and nerve cells were retained in the mice if they were given a drug that had been administered to treat human patients.
The Latest on: Glaucoma
[google_news title=”” keyword=”glaucoma” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Glaucoma
- Understanding glaucoma in cats: A guide for pet ownerson February 27, 2024 at 12:41 am
Early detection and proactive management of glaucoma improve outcomes for cats and owners, enhancing quality of life. Vigilance is key.
- Foreign News: Glaucomaon February 26, 2024 at 3:48 pm
James Ramsay MacDonald, Prime Minister of Great Britain, was scheduled to go to Geneva last week to plead for the peace of the world.
- A clearer image of glaucoma: The relationship between unfolding and aggregation for glaucoma-associated myocilinon February 26, 2024 at 8:39 am
From Parkinson's and Alzheimer's to cardiac arrhythmia, amyloids are linked to a number of diseases. These aggregates of proteins form in the body when a protein loses its normal structure and ...
- Skye Bioscience Completes Enrollment of Phase 2a Clinical Trial of SBI-100 Ophthalmic Emulsion in Glaucoma and Ocular Hypertensionon February 26, 2024 at 4:00 am
Targeted enrollment of 54 patients completed ahead of scheduleSAN DIEGO, Feb. 26, 2024 (GLOBE NEWSWIRE) -- Skye Bioscience, Inc. (OTCQB: SKYE) ("Skye" or the "Company”), a clinical-stage biotechnology ...
- GPT-4 better than eye specialists in retina & glaucoma management: Studyon February 24, 2024 at 11:28 am
OpenAI's based GPT-4 can match and in some cases outperform human ophthalmologists in the diagnosis and treatment of patients with glaucoma and retina disease, according to a research.
- AI outperforms ophthalmologists in diagnosing glaucoma, retinal diseaseon February 23, 2024 at 7:21 am
Artificial intelligence can match and even outperform human eye doctors in diagnosing and treating glaucoma, a new study finds. The GPT-4 system from OpenAI did as well or better than ophthalmologists ...
- AI Outperforms Eye Docs in Managing Glaucomaon February 23, 2024 at 4:08 am
AI outperformed eye doctors in response to glaucoma diagnosis and management, results show. For retinal disease, AI matched humans in accuracy, but exceeded them in completeness. Advanced AI tools ...
- Beware of glaucomaon February 20, 2024 at 4:00 pm
He referred me to a glaucoma specialist. Since he has been my ophthalmologist for about 30 years, why would he refer me to a glaucoma specialist at this time? As I walked to the front desk to book ...
- Novel genetic locations associated with primary open-angle glaucoma identifiedon February 20, 2024 at 10:33 am
An international genetic study using multiancestry biobanks has identified novel genetic locations associated with primary open-angle glaucoma (POAG), the most common type of glaucoma and the leading ...
via Bing News