Snapshots of video images showing a single cluster of artificial cells exhibiting a single beat-like oscillation as the temperature was changed above or below 37 ?C; scale bar, 50 ?m.
Credit: Dr Pierangelo Gobbo, University of Bristol
A tissue-like material capable of synchronised beating when heated and cooled has been developed by a team of University of Bristol chemists.
The discovery, published in Nature Materials, is the first chemically programmed approach to producing an artificial tissue. The findings, which could have major health applications in the future, could see chemically programmed synthetic tissue being used to support failing living tissues and to cure specific diseases.
The development of synthetic tissue which can mimic the ability of living cells to produce functions such as beating and chemical detoxification has, until now, remained a major synthetic biology challenge.
A team, led by Professor Stephen Mann FRS and Dr Pierangelo Gobbo from Bristol’s School of Chemistry, chemically programmed artificial synthetic cells known as protocells to communicate and interact with each other in a highly co-ordinated way.
The researchers constructed two types of artificial cells each having a protein-polymer membrane but with complementary surface anchoring groups. The team then assembled a mixture of the sticky artificial cells into chemically-linked clusters to produce self-supporting artificial tissue spheroids. By using a polymer that could expand or contract as the temperature was changed below or above 37 ?C, it was possible to make the artificial tissues undergo sustained beat-like oscillations in size.
The team was able to increase the functionality of the artificial tissues by capturing enzymes within their constituent artificial cells. Using various combinations of enzymes, the team was able to modulate the amplitude of the beating and control the movement of chemical signals in and out of the artificial tissues.
Professor Stephen Mann FRS, Professor of Chemistry at Bristol and lead author, said: “Our approach to the rational design and fabrication of prototissues bridges an important gap in bottom-up synthetic biology and should also contribute to the development of new bioinspired materials that work at the interface between living tissues and their synthetic counterparts.”
Dr Pierangelo Gobbo, lead author, added: “Our methodology opens up a route from the synthetic construction of individual protocells to the co-assembly and spatial integration of multi-protocellular structures. In this way, we can combine the specialisation of individual protocell types with the collective properties of the ensemble.”
Learn more: Scientists create synthetic prototissue capable of synchronised beating
The Latest on: Artificial tissue
via Google News
The Latest on: Artificial tissue
- Synthetic Organisms Self-Replicate in a New Wayon November 30, 2021 at 4:00 am
A team of biologists and computer scientists show clusters of cells when freed from their original context in a developing organism, can find and combine loose cells into clusters that look and move ...
- Artificial Cornea and Corneal Implant Marketon November 29, 2021 at 9:20 pm
The Europe Artificial Cornea and Corneal Implant Market is expected to reach US 196 62 million by 2028 from an estimated value of US 123 20 million in 2021 it is likely to grow at a CAGR of 7 4 ...
- Perimeter Medical Imaging AI Reports Third Quarter 2021 Financial Results and Provides Corporate Updateon November 29, 2021 at 1:32 pm
Perimeter Medical Imaging AI, Inc. (TSX-V:PINK) (OTC:PYNKF) (FSE:4PC) (“Perimeter” or the “Company”), a medical technology company driven to transform cancer surgery with ultra-high-resolution, ...
- How AI is aiming at the bad math of drug developmenton November 29, 2021 at 9:42 am
Drug makers and investors are spending billions of dollars to turbocharge the search for new treatments using AI.
- Samsung’s Push to Leverage Artificial Intelligence on Display at RSNA 2021on November 29, 2021 at 6:00 am
Samsung Electronics Co. Ltd. will showcase its premium diagnostic imaging solutions in ultrasound, digital radiography and mobile computed tomography at the Radiological Society of North America (RSNA ...
- Top Opportunities for Artificial Intelligence to Improve Cancer Careon November 29, 2021 at 5:30 am
By implementing artificial intelligence into cancer care, machine learning tools can detect cancer, assist in decision-making, and recommend treatment approaches.
- Body Vision Medical Celebrates 1,000th Patient to Benefit from AI-Driven Lung Cancer Diagnostics Imagingon November 29, 2021 at 5:17 am
Body Vision Medical, the pioneer in real-time artificial intelligence imaging for lung cancer diagnostics, announced that 1,000 patients have benefited from LungVision procedures. Body Vision has FDA ...
- Spinal cord scaffold sends regenerating neurons in the right directionon November 28, 2021 at 10:28 pm
Where some parts of the human body are able to heal relatively well following an injury, a damaged spinal cord is one that has a notoriously difficult time. But a new type of artificial scaffold is ...
- Cell and Tissue Culture Supplies Market Scenario Highlighting Major Drivers & Trends, 2021-2031on November 28, 2021 at 8:12 am
Global Cell and Tissue Culture Supplies Market held USD 19 billion in 2020 and is to grow with a CAGR of 11.5% from 2020-2030. Cell culture is the mechanism by which the cells are grown under suitable ...
via Bing News
