Researchers from Eindhoven University of Technology (TU/e) and Keio University today present a practicable and reliable way to test for infectious diseases.
All you need are a special glowing paper strip, a drop of blood and a digital camera, as they write in the scientific journal Angewandte Chemie. Not only does this make the technology very cheap and fast – after twenty minutes it is clear whether there is an infection – it also makes expensive and time-consuming laboratory measurements in the hospital unnecessary. In addition, the test has a lot of potential in developing countries for the easy testing of tropical diseases.
The test shows the presence of infectious diseases by searching for certain antibodies in the blood that your body makes in response to, for example, viruses and bacteria. The development of handy tests for the detection of antibodies is in the spotlight as a practicable and quick alternative to expensive, time-consuming laboratory measurements in hospitals. Doctors are also increasingly using antibodies as medicines, for example in the case of cancer or rheumatism. So this simple test is also suitable for regularly monitoring the dose of such medicines to be able to take corrective measures in good time.
The use of the paper strip developed by the Dutch and Japanese researchers is a piece of cake. Apply a drop of blood to the appropriate place on the paper, wait twenty minutes and turn it over. “A biochemical reaction causes the underside of paper to emit blue-green light,” says Eindhoven University of Technology professor and research leader Maarten Merkx. “The bluer the color, the higher the concentration of antibodies.” A digital camera, for example from a mobile phone, is sufficient to determine the exact color and thus the result.
The color is created thanks to the secret ingredient of the paper strip: a so-called luminous sensor protein developed at TU/e. After a droplet of blood comes onto the paper, this protein triggers a reaction in which blue light is produced (known as bioluminescence). An enzyme that also illuminates fireflies and certain fish, for example, plays a role in this. In a second step, the blue light is converted into green light. But here comes the clue: if an antibody binds to the sensor protein, it blocks the second step. A lot of green means few antibodies and, vice versa, less green means more antibodies.
The ratio of blue and green light can be used to derive the concentration of antibodies. “So not only do you know whether the antibody is in the blood, but also how much,” says Merkx. By measuring the ratio precisely, they suffer less from problems that other biosensors often have, such as the signal becoming weaker over time. In their prototype, they successfully tested three antibodies simultaneously, for HIV, flu and dengue fever. Merkx expects the test to be commercially available within a few years.
The Latest on: Test for infectious diseases
[google_news title=”” keyword=”test for infectious diseases” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Test for infectious diseases
- Care Plan Your Doctor Would Usually Recommend For Infectious Mononucleosison March 2, 2024 at 1:28 pm
This causes extreme fatigue, fever and sore throat.Symptoms Symptoms such as fever and sore throat usually lessen within a few weeks, but fatigue, enlarged lymph nodes, and a swollen spleen may last ...
- Measles is one of the deadliest and most contagious infectious diseases – and one of the most easily preventableon March 1, 2024 at 8:11 pm
Read more about Measles is one of the deadliest and most contagious infectious diseases – and one of the most easily preventable on Devdiscourse ...
- Tackling long-haul diseaseson February 28, 2024 at 4:00 am
Long-haul covid and chronic Lyme disease are surprisingly similar. MIT immunoengineer Mikki Tal is on the case.
- Everything You Need to Know About Lyme Diseaseon February 27, 2024 at 4:00 pm
Some commercial laboratories test ticks for Lyme disease ... for at least 36 hours to transmit the bacterium. Most Lyme disease infectious are caused by immature ticks, called nymphs.
- DiaCarta partners with OncoAssure for prostate cancer test commercializationon February 27, 2024 at 12:33 pm
DiaCarta, Inc., a pioneer in molecular diagnostic test development for cancer and infectious diseases, based in California, today announced that it has established a strategic collaboration with ...
- New disease testing component facilitates lower-cost diagnosticson February 26, 2024 at 4:00 pm
Biomedical researchers have developed a new, less expensive way to detect nuclease digestion -- one of the critical steps in many nucleic acid sensing applications, such as those used to identify ...
- Comprehensive Overview Of The Rapid Infectious Disease Test Market Along With Emerging Trends, Challenges, And Potential Threatson February 22, 2024 at 3:05 am
ResearchVise provides an analysis of the key trends in each sub-segment of Rapid Infectious Disease Test market along with forecasts at global, regional, and country-level analysis from 2024 to 2032.
- Study offers new clues into the causes of post-infectious chronic fatigue syndromeon February 21, 2024 at 5:32 am
Now researchers can test whether these findings apply to a larger patient group and move towards identifying treatments that target core drivers of the disease." A team of multidisciplinary ...
- How Common Are False Positive Rapid COVID Tests?on February 20, 2024 at 4:00 pm
clinicians should always use clinical judgment when interpreting the test," Kruti Yagnik, DO, an infectious diseases specialist from Cleveland Clinic Indian River Hospital in Vero Beach ...
via Bing News