UTMB develops a universal vaccine platform that’s cheaper and shelf stable
Researchers at The University of Texas Medical Branch at Galveston have developed a less expensive way to produce vaccines that cuts the cost of vaccine production and storage by 80 percent without decreasing safety or effectiveness. The findings are currently available in EBioMedicine.
Vaccines are the most effective way to prevent and eradicate infectious diseases. Currently, many vaccines have to be manufactured in cell culture or eggs, which is expensive and carries the risk of contaminations. In addition, most vaccines must be kept refrigerated during the transportation from manufacturers to health care clinics. In tropical and subtropical regions, such cold storage requirements could contribute to more than 80 percent of the vaccine cost.
“The ability to eliminate cell culture or eggs and cold storage will change the process of vaccine development,” said UTMB’s Pei-Yong Shi, professor in the department of biochemistry and molecular biology. “Importantly, this vaccine technology could potentially serve as a universal platform for development of live-attenuated vaccines for many viral pathogens.”
To achieve these goals, the UTMB team engineered a live-attenuated Zika vaccine in the DNA form. Once the DNA is delivered into our body, it launches the vaccine in our cells, leading to antibody production and other protective immunity. With this production method, there is no need to manufacture the vaccine in cell culture or eggs at factories. Because DNA molecules are shelf stable, the vaccine will not expire at warm temperatures and could be stockpiled at room temperature for years.
Using UTMB’s Zika vaccine as a model, the research group showed that the DNA platform worked very efficiently in mice. After a single low dose, the DNA vaccine protected mice from Zika virus infection, mother-to-fetus transmission during pregnancy and male reproductive tract infection and damage.
“This is the first study to demonstrate that, after a single low dose, a DNA vaccine could induce saturated protective immunity,” Shi said. “We will continue testing this promising Zika vaccine platform and then apply the platform to other viruses.”
The Latest on: Vaccine production
via Google News
The Latest on: Vaccine production
- AstraZeneca denies taking vaccines from EU to sell elsewhereon January 27, 2021 at 1:13 am
British pharmaceutical company AstraZeneca, which has been challenged in Europe over delays in deliveries of its Covid-19 vaccine, is "certainly not taking vaccines from Europeans to sell them el ...
- Biden says US to buy 200 million more COVID vaccine doseson January 27, 2021 at 1:11 am
Joe Biden says US will accelerate delivery of vaccines to states and localities, but warns progress will take time.
- Biden administration to boost COVID-19 vaccine supply amid shortageson January 27, 2021 at 1:10 am
The White House says it's purchasing more Pfizer and Moderna vaccines - ensuring enough doses to fully vaccinate 300 million Americans by the end of this summer.
- Vaccine rollout stumbles as a 'Hunger Games' approach leaves states and counties to fend for themselveson January 27, 2021 at 1:00 am
Johnson & Johnson's CFO Joe Wolk explains why the company is optimistic about seeking emergency use authorization for its vaccine in the coming weeks.
- Astra Chief’s Response to EU’s Vaccine-Delay Claims: Main Pointson January 27, 2021 at 12:58 am
AstraZeneca Plc said it’s not backsliding on any vaccine-delivery commitments to the European Union, setting the stage for showdown with the bloc over a crunch call later on Wednesday.
- E.U. threatens drug companies with legal action if it doesn’t get its vaccineson January 26, 2021 at 8:24 pm
The European Union on Tuesday stepped up pressure on pharmaceutical companies it says have hobbled coronavirus vaccine rollouts, proposing tighter export controls and threatening potential legal ...
- Sanofi to Collaborate With BioNTech on Coronavirus Vaccine Productionon January 26, 2021 at 5:03 pm
Global News Select Sanofi to Collaborate With BioNTech on Coronavirus Vaccine Production . . Jan 27, 2021 7:03 AM UTC ...
- Murphy's message to Biden? Ramp up vaccine productionon January 26, 2021 at 12:22 pm
"At the top of the list right now has got to be ramping up the manufacturing of vaccine doses," he said. New Jersey, like other states around the country, is grappling with too few vaccines to meet ...
- Sanofi, after R&D setback, lends a hand to vaccine rival Pfizer for coronavirus shot productionon January 26, 2021 at 11:03 am
Following its midstage coronavirus R&D setback, vaccine giant Sanofi is still looking for ways to help in the world’s effort to beat back the pandemic. It’s teaming up with leading vaccine players ...
via Bing News