Scientists at The University of Manchester have developed the first non-antibiotic drug to successfully treat tuberculosis in animals.
The team hope the compound –developed after 10 years of painstaking research will be trialled on humans within three to four years.
The drug- which works by targeting Mycobacterium tuberculosis’ defences rather than the bacteria itself – can also take out its increasingly commonly antibiotic resistant strains.
The research funded by the Medical Research Council – is published today in the Journal of Medicinal Chemistry.
Although a vaccine for TB was developed 100 years ago, one in three people across the world are thought to be infected with the infectious disease.
About 1.7 million die from the bug each year worldwide and 7.3 million people were diagnosed and treated in 2018, up from the 6.3 million in 2016.
It is most common in Africa, India and China, but on the rise in the UK with London often described as the TB capital of Europe.
Patients are forced to take a cocktail of strong antibiotics over 6 to 8 months, often enduring unpleasant side effects with a 20% risk that the disease will return.
But now The University of Manchester team’s discovery has been proven effective in guinea pigs at Rutgers University in the United States.
The animals with acute and chronic TB infection were treated with the compound, which was discovered after investigating dozens of other derivatives and compounds thought to have similar properties.
Professor Lydia Tabernero is the project leader. She said: “The fact that the animal studies showed our compound, which doesn’t kill the bacteria directly, resulted in a significant reduction in the bacterial burden is remarkable.
“For more than 60 years, the only weapon doctors have been able to use against TB is antibiotics. But resistance is becoming an increasingly worrying problem and the prolonged treatment is difficult and distressing for patients.
“And with current treatments, there’s no guarantee the disease will be eliminated: antibiotics do not clear the infection and the risk of being infected with drug-resistant bacteria is very high.
“But by disabling this clandestine bacteria’s defences we’re thrilled to find a way that enhances the chances of the body’s immune system to do its job, and thus eliminate the pathogen.”
Mycobacterium Tuberculosis secretes molecules called Virulence Factors – the cell’s secret weapon -which block out the immune response to the infection, making it difficult to treat.
The team identified one Virulence Factor called MptpB as a suitable target, which when blocked allows white blood cells to kill Mycobacterium Tuberculosis in a more efficient way
Professor Tabernero added: “The great thing about MptpB is that there’s nothing similar in humans – so our compound which blocks it is not toxic to the human cells.
“Because the bacteria hasn’t been threatened directly, it is less likely to develop resistance against this new agent, and this will be a major advantage over current antibiotics, for which bacteria had already become resistant.
“TB is an amazingly difficult disease to treat so we feel this is a significant breakthrough.
”The next stage of our research is to optimise further the chemical compound, but we hope clinical trials are up to four years away.”
Learn more: Scientists develop new drug treatment for TB
The Latest on: Tuberculosis
via Google News
The Latest on: Tuberculosis
- Private Road Ambulance Services in Patna Saved the life of Tuberculosis Patienton January 24, 2021 at 3:40 am
We all know the sound of sirens screaming behind us, and we all recognize the red and blue lights flashing in harmony, letting us know that emergency vehicles are approaching and we must be vigilant.
- Tuberculosis Drugs Market Share 2021 Explosive Growth Analysis, Market Size, Trends, Top Manufacturers and Forecasts to 2025on January 20, 2021 at 5:35 am
Final Report will add the analysis of the impact of COVID-19 on this industry” Global “Tuberculosis Drugs Market” ...
- Tuberculosis screening to be carried out for Singapore Pools Bedok Betting Centre patrons after 2 clusters foundon January 20, 2021 at 3:02 am
The two separate clusters involve a total of 18 people, who frequently visited the Bedok centre over periods ranging from months to years.. Read more at straitstimes.com.
- Precautionary tuberculosis screening for some Singapore Pools Bedok Betting Centre patrons after 18 cases detected: MOHon January 20, 2021 at 1:49 am
Precautionary tuberculosis screening will be conducted for certain patrons of Singapore Pools Bedok Betting Centre after 18 cases were ...
- Proposing a new drug to treat tuberculosis utilizing state-of-the-art computer simulationson January 17, 2021 at 9:00 pm
In silico drug design for inhibiting the cell division of Mycobacterium tuberculosis and suppressing its growth based on high-precision molecular simulations The research team of the Department of ...
- Tuberculosis has vaccine lessons for Covidon January 17, 2021 at 6:57 pm
In the early 1900s, one of the leading causes of death in places like the UK was a lung disease called tuberculosis (TB). What has happened since is an important warning for how the world should be ...
- Tuberculosis kills as many people each year as COVID-19. It's time we found a better vaccineon January 15, 2021 at 6:22 am
In July 1921, a French infant became the first person to receive an experimental vaccine against tuberculosis (TB), after the mother had died from the disease. The vaccine, known as Bacille ...
- Prescription for tuberculosis a century ago? A shot of Harrisburg’s fresh air | Columnon January 15, 2021 at 5:55 am
Efforts in central Pennsylvania to prevent deadly tuberculosis in children included an open-air school, which got a bit chilly in winter, and a summer camp that offered plenty of relaxation.
- Sea lion diagnosed with tuberculosis triggers public health concernson January 14, 2021 at 6:30 am
Australian sea lions are an endangered species. New research suggests endemic tuberculosis might be another health threat facing the pinnipeds. Dr. Rachael Gray is working to help save our sea lions.
via Bing News