
The small SynuClean-D molecule interrupts the formation of the alpha-synuclein amyloid fibres responsible for the onset of Parkinson’s disease, and reverts the neurodegeneration caused by the disease. The study headed by UAB researchers was published in PNAS.
Parkinson’s disease is the second most common incurable neurodegenerative disorder after Alzheimer’s disease.
It is characterised by the accumulation of protein deposits in dopaminergic neurons (in charge of producing dopamine) in the form of amyloid fibres. These aggregates are formed mainly by the alpha-synuclein protein and in a very complex manner, which makes it complicated to identify molecules which could prevent or revert the process and the neurodegeneration associated with it.
A scientific collaboration led by researchers at the Institute of Biotechnology and Biomedicine (IBB) of the Universitat Autònoma de Barcelona has identified a molecule which halts and reverts this neurodegeneration. After analysing over 14,000 molecules, they found the SynuClean-D molecule, which inhibits the aggregation of the alpha-synuclein protein and breaks the already formed amyloid fibres, thus preventing the initiation of the process causing the onset of the neurodegenerative Parkinson’s disease.
Through experiments conducted with the small Caenorhabditis elegans worm, one of the most commonly used animal models in neurodegenerative diseases, researchers were able to verify that by administering it through food, the molecule was capable of notably reducing alpha-synuclein aggregations, preventing the spread of toxic aggregates and therefore avoiding the degeneration of dopaminergic neurons.
“Everything seems to indicate that the molecule we identified, the SynuClean-D, may provide therapeutic applications for the treatment of neurodegenerative disases such as Parkinson’s in the future”, UAB researcher and coordinator of the study Salvador Ventura points out.
To identify SynuClean-D researchers developed a methodology capable of indentifying the alpha-synuclein aggregation inhibitors among thousands of molecules. Once identified, an in vitro biophysical characterisation was conducted of their inhibiting activity and tests were run to discover their behaviour with human neural cell cultures, before testing it in animal models of the disease (the Caenorhabditis elegans worm). These animals express the alpha-synuclein in the muscle or in dopaminergic neurons. The experiments demonstrated that the administration of the identified inhibitor reduced protein aggregation, improving the mobility of the animal and protecting it from neural degeneration.
Learn more:Â Molecule capable of halting and reverting neurodegeneration caused by Parkinson’s disease identified
The Latest on: Parkinson’s
[google_news title=”” keyword=”Parkinson’s” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Parkinson’s
- Un estudio evidencia que el Parkinson afecta de forma diferente a hombres y mujereson February 9, 2023 at 1:37 am
Un nuevo estudio del proyecto 'COPPADIS', impulsado por el Grupo de Estudio de Trastornos del Movimiento (GETM) de la Sociedad Española de Neurología (SEN), y que ha sido publicado en el 'Journal of C ...
- El Parkinson afecta de forma diferente a hombres y mujereson February 8, 2023 at 11:54 pm
Un nuevo estudio del proyecto 'COPPADIS', impulsado por el Grupo de Estudio de Trastornos del Movimiento (GETM) de la Sociedad Española de Neurología (SEN), y que ha sido publicado en el 'Journal of C ...
- Cirugía de estimulación cerebral profunda para la enfermedad de Parkinsonon February 8, 2023 at 11:29 am
En entrevista con Martha Debayle en W, Yamil Matuk, especialista en Neurología, alta Especialidad en Enfermedad de Parkinson, Trastornos del Movimiento y Enfermedades Neurodegenerativas por el Institu ...
- El Cabildo de Fuerteventura mantiene su apoyo a las personas con párkinson de la isla a través del convenio con Fuertevidaon February 8, 2023 at 7:35 am
El vicepresidente y consejero de accesibilidad del Cabildo de Fuerteventura, Juan Nicolás Cabrera, ha mantenido hoy, miércoles 8 de febrero, una reunión con los representantes de Fuerte es la Vida Pár ...
- “El Parkinson me liberó del alcoholismo”: La historia de Ricardo Jaime, desde las calles de Antofagasta a publicar su primer libroon February 7, 2023 at 9:23 am
Con la guía de una psicopedagoga que hizo la práctica en la Hospedería de Antofagasta, donde vive desde hace 9 meses, logró ver su testimonio de vida escrito en un libro. Empeñoso y cristiano, tuvo un ...
- Protitpo para ayudar a personas con parkinson y disfagiaon February 7, 2023 at 4:54 am
Espaitec, Parque Científico y Tecnológico de la Universitat Jaume I de Castellón, ha iniciado el proyecto Spender, articulado a través del UJI. LAB Challenge.
- Sara Blanco, la nonagenaria que visibiliza el párkinson en redes socialeson February 6, 2023 at 10:36 am
Con 91 años y párkinson, Sara Blanco es una influencer y modelo a seguir con más de 158 mil seguidores en Instagram ...
- Visibiliza el Parkinson en Instagramon February 6, 2023 at 1:04 am
Sara Blanco, una vecina de Marbella de 91 años que sufre Parkinson, batalla diariamente contra esta enfermedad y la visibiliza en su perfil de la red social Instagram, donde enseña su pasión por la mo ...
- Parkinson: consejos de expertos para controlar los síntomas y manejar la enfermedadon February 3, 2023 at 8:08 am
La enfermedad de Parkinson es un tipo de trastorno del movimiento. La Biblioteca Nacional de Medicina de Estados Unidos explica que esta afección se presenta cuando las células nerviosas (neuronas) no ...
via Bing News