
Enzyme nanobots pump fluid and convert nerve agents into harmless products.
Credit: Ayusman Sen
Once in the territory of science fiction, “nanobots” are closer than ever to becoming a reality, with possible applications in medicine, manufacturing, robotics and fluidics. Today, scientists report progress in developing the tiny machines: They have made nanobot pumps that destroy nerve agents, while simultaneously administering an antidote.
According to Ayusman Sen, Ph.D., the project’s principal investigator, this study arose from more general research aimed at making nanobots from enzymes. “We have been looking at how to convert chemical energy into motion,” he says. “We take the energy that’s generated from catalytic reactions to cause the motion of enzymes.”
To make his nanobots, Sen and his group at The Pennsylvania State University used enzymes found in nature. These are proteins that help specific chemical reactions occur, converting a reactant (raw material) into a product.
The realization that enzymes can move when catalyzing a reaction is a relatively new discovery. Previously, scientists thought that these proteins drifted along in the cytoplasm of the cell by passive diffusion, encountering their reactants and other enzymes by more-or-less chance interactions. However, Sen and others have recently shown that when enzymes catalyze a reaction, they move. Researchers still aren’t sure how this motion occurs, but it likely involves a change in the shape of the enzyme upon catalysis. Sen’s group has shown that these proteins can even swim along a path toward higher levels of reactant. These features make enzymes an attractive material for developing nanobots.
“If we take enzymes and anchor them to a surface so they cannot move, and we give them their reactant, they end up pumping the fluid surrounding them,” Sen says. “So they act as miniature fluid pumps that can be used for a variety of applications.” He notes that the nanobots pump liquid at the rate of several microliters — or millionths of a liter –- per second.
Sen and his coworkers made nanobots to neutralize organophosphates, a class of nerve agents. Exposure to these chemicals during military combat or terrorist attacks can cause permanent neurological damage, and in some cases, death. An enzyme, called organophosphorus acid anhydrolase, can destroy these nerve agents. The researchers immobilized this enzyme on a gel that also contained an antidote. Exposure to organophosphates activates the enzyme. “The enzyme actively pumps in the organosphosphate compound and destroys it, and at the same time pumps out an antidote,” Sen says. Importantly, the system requires no external power source because the enzyme is fueled by the organophosphate reactant.
The nanobot pumps might someday be incorporated into protective clothing for the military or first responders, Sen says. He is also exploring applications for nanobots based on other enzymes, for example, an insulin-pumping device to treat diabetes and an enzyme-powered drug-delivery system. The Pennsylvania State University has filed a patent application on the promising new technology. “If you want to make pumps that will pump very small amounts of liquid in a very precise way, this is one way to do that,” Sen says.
This research was presented at a meeting of the American Chemical Society
Learn more: Nanobot pumps destroy nerve agents
The Latest on: Nanobots
via Google News
The Latest on: Nanobots
- How Suicide Squad's Amanda Waller SECRETLY Created Batman Beyondon January 19, 2021 at 2:11 pm
Justice League Unlimited revealed the Suicide Squad's Amanda Waller was behind the creation Batman Beyond's Terry McGinnis.
- Nano-Biological Machines, Nanobots, … are we there yeton January 18, 2021 at 4:00 pm
As a science fiction fanatic, futuristic imaginations fascinate me. “Think about the recent science fictions, where the injured soldier’s wound gets quickly fixed and healed by a swarm of tiny robots ...
- Technology can enhance exercise, but it can never replace it. Or can it?on January 16, 2021 at 2:05 pm
With virtual fitness trainers already out in the world, can exercise avatars and nanobots be far behind? Devlin Brown reviews workout trends for 2021 As she straps the smart watch to her wrist ...
- Nanobots Swim Like Scallops In Non-Newtonian Fluidson January 11, 2021 at 4:00 pm
The idea of using nanobots to treat diseases has been around for years, though it has yet to be realized in any significant manner. Inspired by Purcell’s Scallop theorem, scientists from the Max ...
- Nanobots Could Remove Arterial Plaqueon January 5, 2021 at 4:00 pm
Less far-fetched is a Ukrainian research project that proposes using nanobots to attack atherosclerotic plaque. At present, rotational atherectomy can be used to remove plaque, but can lead to ...
- How Much Smarter?on December 29, 2020 at 4:00 pm
"We'll be able to send intelligent machines the size of blood cells - I call them nanobots - through our blood stream, " he says. "You can swallow them. Billions of them will take up positions in ...
- In the ‘new normal’, innovations, inventions & contactless experiences will rule the retail spaceon December 2, 2020 at 8:35 pm
It is rightly said that some of the biggest changes need some situations like COVID-19 to bring about important transformation. The crisis has increased digital adoption significantly with companies ...
- Researchers attack cancer cells with liquid metal ‘nano-terminators’on August 17, 2020 at 1:23 am
If you’ve ever read Ray Kurzweil’s books, you know that he envisions a future in which benevolent little nanobots flow through our bodies attacking malicious forms of disease. While Kurzweil ...
- What Will Health and Medicine Look Like in 2050?on December 23, 2019 at 10:20 am
Bottom-right quadrant, Overhyped and Prediction predictions from top center: Injectable nanobots deliver targeted therapies next to illustration of nanobot; Microbiome therapies make billions next to ...
- nanoRISK Newsletteron April 3, 2019 at 9:28 am
Why a newsletter about nanotechnology risks? Are we scaremongers? No; and we are not covering killer nanobots and grey goo either. Much of nanotechnology today is about producing nanoscale particles ...
via Bing News