Chemically coated, ceramic implants successfully guided the regrowth of missing bone in lab animals while “steadily dissolving,” researchers report.
Surgeons and scientists at NYU School of Medicine and NYU College of Dentistry say their implanted scaffolds were naturally absorbed by the test animals’ bodies as new bone gradually replaced the devices. The research team describes its progress in a series of reports, the latest of which appears online July 25 in the Journal of Tissue Engineering and Regenerative Medicine.
Modeled after the bone pieces they are meant to help replace, the implants were assembled onsite using three-dimensional robotic printing, a technology that uses a fine-point print head to push out a gel-like ink material. The material is printed onto a platform, and the printer repeats the process until two-dimensional layers stack up into a three-dimensional object, which is then superheated into its final ceramic form. Available for more than a decade, the technology has only of late been applied in medicine to print out replacement ears, skin, and heart valves.
“Our three-dimensional scaffold represents the best implant in development because of its ability to regenerate real bone,” says study senior investigator and biomedical engineer Paulo G. Coelho, DDS, PhD. “Our latest study results move us closer to clinical trials and potential bone implants for children living with skull deformations since birth, as well as for veterans seeking to repair damaged limbs,” adds Dr. Coelho, who is the Dr. Leonard I. Linkow Professor at NYU Dentistry and a professor of plastic surgery at NYU School of Medicine.
The scientists say their novel ceramics more closely resemble real bone shape and composition than other experimental bone implants in which plastic elasticizers are added to make the implant flex. Although the ability to flex offers some advantages, the plastic does not have the same healing ability as the NYU scaffold.
An important feature of the ceramic devices is that they are made of beta tricalcium phosphate, a compound of the same chemicals found in natural bone that makes the implants resorbable.
One of the secrets to the rapid growth of native bone with the NYU devices is a coating of dipyridamole, a blood thinner shown in other experiments to speed up bone formation by more than 50 percent. The chemical also attracts bone stem cells, which spur the formation of nourishing blood vessels and bone marrow within the newly grown bone. These soft tissues, researchers say, lend to their scaffold-grown bone the same flexibility as natural bone.
“Dipyridamole has proven to be key to the implant’s success,” says study co-investigator Bruce N. Cronstein, MD, the Dr. Paul R. Esserman Professor of Medicine at NYU School of Medicine, who perfected the drug’s use during device testing. Used for more than a half-century to prevent blood clots and treat stroke, dipyridamole has a long-standing safety record, says Dr. Cronstein, who also serves as the director of the Clinical and Translational Science Institute, and chief of the Division of Translational Medicine at NYU Langone Health. “And because the implant is gradually resorbed, the drug is released a little at a time and locally into the bone, not into the whole body, thereby minimizing risks of abnormal bone growth, bleeding, or other side effects.”
In the latest experiments, researchers used the test scaffolds to repair small holes surgically made in the skulls of mice and missing bone pieces as long as 1.2 centimeters in rabbit limbs and jaws.
The scientists found that on average 77 percent of each scaffold was resorbed by the mammal’s body 6 months after implantation. They also found that new bone grows into the lattice-like structural supports of the scaffold, which then dissolves. Some CT scans of the implant sites showed almost no trace of beta tricalcium phosphate, the three-dimensional–printed material of which the original implants were made.
Subsequent weight-bearing tests showed that the new bone was of equivalent strength as original, undamaged bone.
The investigators say their next studies will test the scaffolds, for which they have a patent pending, in larger animals. They caution that clinical trials are still several years away.
The Latest on: Ceramic implants
[google_news title=”” keyword=”ceramic implants” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Ceramic implants
- Medical Ceramics Market, Size, Global Forecast Report, 2023-2024 and 2030on February 29, 2024 at 4:50 am
The "Medical Ceramics Market, Size, Global Forecast 2024-2030, Industry Trends, Share, Growth, Insight, Impact of Inflation, Companies Analysis" report has been added to ResearchAndMarkets.com's ...
- Philadelphia Police seek suspect who stole $100K in spine implants from caron February 25, 2024 at 5:38 pm
Philadelphia Police are seeking the public's help in identifying a suspect who they said stole over $100,000 worth of spine implants from a car inside a parking garage in Center City last week.
- Best Dental Insurance for Implants of 2024on February 25, 2024 at 7:34 am
Elizabeth Rivelli is an insurance writer passionate about helping people navigate the complex world of insurance to help them make empowered choices. Delta Dental is the best dental insurance ...
- What to know about penile implantson February 23, 2024 at 4:00 pm
Penile implants, also referred to as penile prostheses, offer a viable solution for individuals grappling with erectile dysfunction (ED) that remains unresponsive to conventional treatments.
- Charlie Sheen and Denise Richards' daughter Sami, 19, wants new breast implants 3 months after first surgeryon February 23, 2024 at 1:59 pm
The OnlyFans model, who is the daughter of Charlie Sheen and Denise Richards, got breast implants in November, but in a new TikTok, she said that she already wants to get "bigger" breasts.
- Woman Gets Dental Implants, Realizes They Do Something Wild in the Nightclubon February 22, 2024 at 7:47 am
Dental implants are supposed to make your smile look better, but they made a TikTok user's mouth stand out in all the wrong ways because they made her look like a gap-toothed yokel. In a TikTok video ...
- Dental Implants: Types, Procedures And How They Workon February 15, 2024 at 2:47 am
The Food and Drug Administration has since approved zirconia implants for use as well. Zirconia, a hard white ceramic material, has grown significantly in popularity in the last five years.
- Questions About Dental Implants? Doctors Have The Answer.on February 10, 2024 at 1:28 pm
Consultation X-rays Preparation of the jawbone Placement of the implant Healing period Attachment of the abutment Placement of the crown Follow-up visitsThis article provides expert advice on how to ...
- Pune hospital conducts state’s 1st ceramic knee replacement surgeryon February 6, 2024 at 8:09 am
The procedure, using special ceramic implants, was performed at city’s Lokmanya Hospital on Friday, making the health hub first in the state to carry out the ceramic total knee replacement surgery.
via Bing News