A research team led by Professor Jaewon Ko and Ji Won Um from Department of Brain and Cognitive Sciences identified a new principle of formation of brain synapses through synaptic binding protein complexes.
Many nerve cells that make up the brain control the function of the brain through synapses*. Although recent studies show that synaptic binding proteins play a certain role in the formation of synapses, detailed factors or processes for collectively controlling the synapses remain unknown.
The research team has been focusing on discovering related binding proteins and finding detailed mechanisms to identify the principles of formation of excitatory synapses among synapses.
In this study, the research team found that the interaction between the PTP? proteins and certain bone proteins among binding proteins plays a critical role in synapse formation. In particular, they have identified that the ‘normal tyrosine signaling mechanism’ resulting from the reaction of certain elements of the PTP? proteins is an essential component of synapse formation.
Given the potential correlation between proteins and mental disorders such as autism, schizophrenia, and depression that recent large-scale human genetics studies have shown, the research team’s experiment is expected to provide important clues to help analyze the causes of brain disorders and enable treatment through further studies of related proteins.
Professor Ko expressed his determination by saying, “As our recent study has reported, PTP? proteins, along with neurexin, are considered key proteins responsible for the development of neural circuits. Our world-leading research team will conduct further studies to continue research on the development of synapses and neural circuits.”
The Latest on: Brain disease
[google_news title=”” keyword=”brain disease” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Brain disease
- Placenta Issues Linked to Newborns' Brain Aberrations in Congenital Heart Diseaseon February 29, 2024 at 4:00 pm
Prior work established that children with fetal congenital heart disease are at greater risk of postnatal brain injury and adverse long-term neurodevelopmental outcomes. Despite continued improvement ...
- Neurological emergency: Rhode Islander recovering from tick-borne disease that inflames brainon February 29, 2024 at 2:22 pm
The 70-year-old Kent County man exhibited symptoms of Pawassan disease in January, according to the Rhode Island Department of Health.
- Interdisciplinary project aims to decode human kinome in brain function and diseaseon February 29, 2024 at 12:25 pm
The Chan Zuckerberg Initiative (CZI) announced four multi-year Exploratory Cell Networks grants for researchers exploring the frontiers of genomics, cell biology, and synthetic biology by developing ...
- In honor of Rare Disease Day, we honor four-year-old Matty, who lives without the middle part of his brainon February 29, 2024 at 6:38 am
In honor of Rare Disease Day, we honor four-year-old Matty, who lives without the middle part of his brain. Mathius, also known as Matty, is a Coachella boy with a rare genetic disorder since birth.
- Alzheimer's Newson February 27, 2024 at 4:00 pm
They were able to show that changes in two important brain regions, the hippocampus and the occipital ... Yoga Provides Unique Cognitive Benefits to Older Women at Risk of Alzheimer's Disease Feb ...
- Sweden's Kristoffer Olsson on ventilator due to brain diseaseon February 27, 2024 at 4:06 am
FC Midtjylland midfielder Kristoffer Olsson is in hospital on a ventilator due to suffering brain disease, the club said on Tuesday.
- How Common Is Frontotemporal Dementia? Wendy Williams Diagnosed with Rare Brain Diseaseon February 26, 2024 at 6:00 am
Former daytime talk show host Wendy Williams has been diagnosed with frontotemporal dementia and primary progressive aphasia, which can lead to issues with communication, judgement, and behavior.
- Could Viruses Help to Protect Your Brain?on February 25, 2024 at 3:59 pm
In recent years, we’ve heard a lot about the health risks of viruses and how they may negatively impact the brain. This amplifies the existing theme of viruses being described as germs or ...
- Silent brain changes precede Alzheimer’s. Researchers have new clues about which come firston February 21, 2024 at 4:16 pm
Alzheimer’s quietly ravages the brain long before symptoms appear and now scientists have new clues about the dominolike ...
via Bing News