Scientists have uncovered a potential approach to treat one of the commonest causes of dementia and stroke in older people.
Studies with rats found the treatment can reverse changes in blood vessels in the brain associated with the condition, called cerebral small vessel disease.
Treatment also prevents damage to brain cells caused by these blood vessel changes, raising hope that it could offer a therapy for dementia.
Small vessel disease, or SVD, is a major cause of dementia and can also worsen the symptoms of Alzheimer’s disease. It is responsible for almost half of all dementia cases in the UK and is a major cause of stroke, accounting for around one in five cases.
Patients with SVD are diagnosed from brain scans, which detect damage to white matter – a key component of the brain’s wiring.
Until now, it was not known how changes in small blood vessels in the brain associated with SVD can cause damage to brain cells.
A team led by the University of Edinburgh found that SVD occurs when cells that line the small blood vessels in the brain become dysfunctional. This causes them to secrete a molecule into the brain.
The molecule stops production of the protective layer that surrounds brain cells – called myelin – which leads to brain damage.
Treating rats with drugs that stop blood vessel cells from becoming dysfunctional reversed the symptoms of SVD and prevented brain damage, tests found.
Researchers say that further studies will need to test whether the treatment also works when the disease is firmly established. They will also need to check if the treatment can reverse the symptoms of dementia.
Dementia is one of the biggest problems facing society, as people live longer and the population ages. Estimates indicate there are almost 47 million people living with dementia worldwide and the numbers affected are expected to double every 20 years, rising to more than 115 million by 2050.
The research, published in Science Translational Medicine, was carried out at the Medical Research Council Centre for Regenerative Medicine and the UK Dementia Research Institute at the University of Edinburgh. It was funded by the MRC, Alzheimer’s Research UK and Fondation Leducq.
Professor Anna Williams, Group Leader at the University of Edinburgh’s MRC Centre for Regenerative Medicine, said: “This important research helps us understand why small vessel disease happens, providing a direct link between small blood vessels and changes in the brain that are linked to dementia. It also shows that these changes may be reversible, which paves the way for potential treatments.”
Dr Sara Imarisio, Head of Research at Alzheimer’s Research UK said: “Changes to the blood supply in the brain play an important role in Alzheimer’s disease as well as being a direct cause of vascular dementia. This pioneering research highlights a molecular link between changes to small blood vessels in the brain and damage to the insulating ‘white matter’ that helps nerve cells to send signals around the brain.
“The findings highlight a promising direction for research into treatments that could limit the damaging effects of blood vessel changes and help keep nerve cells functioning for longer. There are currently no drugs that slow down or stop Alzheimer’s disease and no treatments to help people living with vascular dementia. Alzheimer’s Research UK is very pleased to have helped fund this innovative research, which is only possible thanks to the work of our dedicated supporters.”
The Latest on: Small vessel disease
via Google News
The Latest on: Small vessel disease
- How 'Bleeding' Stroke Affects Brain May Depend on Your Raceon April 22, 2021 at 5:34 am
Black and Hispanic survivors of a bleeding stroke are more likely than white survivors to have changes in small blood vessels in the brain that increase the risk of another bleeding stroke, ...
- Black, Hispanic stroke survivors more likely to have changes in brain's blood vesselson April 21, 2021 at 1:00 pm
Intracerebral hemorrhage is a life-threatening type of stroke caused by bleeding within the brain tissue. Survivors are at high risk of having another bleeding stroke. Most of these strokes are caused ...
- Anticoagulation and cerebral small vessel diseaseon April 7, 2021 at 9:38 am
Werring. It contrasts the role of blood thinning with that of cerebral small vessel disease (SVD) in intracerebral haemorrhages. A moderate to severe cerebral SVD is shown to be closely associated ...
- COVID-19 Worsens Neurological Problems, Deliriumon April 7, 2021 at 9:13 am
"Low blood oxygen seen in some COVID patients, coupled with existing small-vessel disease or cerebral amyloid angiopathy, may easily affect susceptible brain areas." Roger Nitsch, Neurimmune, ...
- Genetic Variants Tied to Sex Differences in Psychiatric Disorderson April 5, 2021 at 11:25 am
One is in cardiovascular disease, where it’s primarily treated as a small vessel disease in women and a large vessel disease in men. Before, most of our treatments were developed for large vessel ...
- Amyloid related cerebral microbleed and plasma Aβ40 are associated with cognitive decline in Parkinson’s diseaseon March 29, 2021 at 3:10 am
Table 3 Multivariable models for cerebral small vessel disease markers in predicting PD dementia. Our results demonstrated a higher prevalence of lobar MBs in PD compared to healthy controls.
- White matter hyperintensities increase long-term risk for ischemic stroke, deathon March 25, 2021 at 9:23 am
White matter hyperintensity volume, type and shape correlated with an increased risk for mortality and ischemic stroke among patients with manifest arterial disease, according to findings from the ...
- Insertable Cardiac Monitors Improve AF Detection After Strokeon March 24, 2021 at 3:33 am
the occurrence of undiagnosed AF is more frequent than we originally thought among stroke patients with large-artery atherosclerosis and small-vessel disease," Ralph L. Sacco, MD, professor and ...
- Leaky blood-brain barrier linked to brain tissue damage in brain aging diseaseon March 23, 2021 at 5:00 pm
As people age, changes in the tiniest blood vessels in the brain, a condition called cerebral small vessel disease, can lead to thinking and memory problems and stroke. These changes can also ...
via Bing News