Bartenders and cooks have long recognized the value of an orange twist, but thanks to researchers at the University of Central Florida, squeezing oranges may give us a new way to deliver medicine or to detect bridge failures before they happen.
Engineering Assistant Professor Andrew K. Dickerson and graduate student Nicholas M. Smith have figured out the mechanics of how oranges release that thin stream of fragrant oil when squeezed. They characterized the orange peels’ structure and figured out the role the layers have to create the microjet dynamic. By mimicking nature’s mechanism of an orange layer, pharmaceutical companies may be able to develop a less expensive and less complex way to deliver airborne medication.
“We study natural systems to mathematically characterize how creation works, and despite the ubiquity of citrus-fruit consumption, these jets had not been previously studied,” Dickerson said. “Nature is our greatest inspiration for tackling real-world problems.”
The team’s findings are published in today’s Proceedings from the National Academy of Sciences.
Florida’s fruit is complex. Its hard outer layer protects the fruit, and a white spongy layer just below the skin has microscopic reservoirs of oil in hidden pockets. The spongy material absorbs impact, but when squeezed to a critical pressure it pushes up and tears open a minute section of the hard outer-layer to spray its fragrant stream. These microjets are small but fast, exiting their cavities at 22 mph on average by accelerating 5,000 Gs, which is equivalent to about 1,000 times the force astronauts feels at launch.
“There are several potential applications,” Smith said. “For example, for asthmatics, you could have a small slice of material which would aerosolize emergency medication that you currently find in expensive, multi-use inhalers. This approach may be less expensive and biodegradable.”
An orange peel releases an oily substance, and the dynamics should hold for other types of liquids, the researchers said.
But there’s still some research needed before putting the orange peel approach to work delivering medication.
“First, we need to work out sizes and proportions,” Dickerson said. “It’s important to understand exactly how the microjets work and how to tune their stability for medical applications. The size of droplets and the amount of medication they carry is critical. We’ve got a ways to go before applications can be explored.”
But when that happens, the possibilities are only limited by the imagination.
“Imagine a self-diagnosing bridge,” Dickerson said. “It would have an orange-like skin layer and when you were approaching material failure, you would get a preventative warning, a color change perhaps.”
Dickerson, a fluid-dynamic expert, is making a career of studying nature. He’s already published several papers looking at what can be learned from the proverbial wet-dog shake and how mosquitos survive raindrop collisions. Studying the shake helps us understand how to self-dry large surfaces such as solar panels. And studying how mosquitos survive rain could help create strategies for combating the disease-carrying insects.
“Few labs nationally do this type of research,” Smith said. “That’s one of the reasons I came to UCF to do my graduate work. This is exciting stuff. Nature has had billions of years to get the engineering principles right and I get to look at them, figure them out and then play with them to solve problems. That’s pretty exciting!”
The Latest on: Drug delivery
via Google News
The Latest on: Drug delivery
- Global Polymers Drug Delivery Market Size, Share, Value, and Competitive Landscape 2020-2026on March 6, 2021 at 4:31 am
Global Polymers Drug Delivery Market Report 2020 comes with the extensive industry analysis of development components, patterns, flows and sizes. The report also calculates present and past market ...
- Global Injectable Drug Delivery System Market 2021 - Industry Analysis by Size, Share, Trends and Forecast to 2026on March 6, 2021 at 1:34 am
The global Injectable Drug Delivery System market research report comprises of the comprehensive overview of all ...
- Just Under 2 Weeks Until SMi’s 2nd Annual AI in Drug Delivery 2021, Sponsored by CAS, Dassault Systèmes and Geroon March 6, 2021 at 12:07 am
Just under two weeks remaining until the 2nd Annual AI in Drug Delivery Conference takes place as a virtual conference on 15 and 16 March 2021. The conference is sponsored by CAS, Dassault Systems and ...
- Aptamer Group Extends Collaboration With AstraZeneca To Explore Next-Generation Drug Delivery Approacheson March 5, 2021 at 8:21 am
Aptamer Group has announced the extension of their current agreement with AstraZeneca. This agreement will further the existing collaboration to evaluate the potential of using Optimer-based ...
- Aquestive Therapeutics to Host Investor & Analyst Virtual Epinephrine Drug Delivery R&D ...on March 4, 2021 at 8:02 pm
Aquestive Therapeutics, Inc. (NASDAQ: AQST), a pharmaceutical company focused on developing and commercializing differentiated products that address patients’ unmet needs and solve therapeutic ...
- Lexaria Bioscience Corp. is Changing the Future of Drug Deliveryon March 2, 2021 at 6:44 pm
Lexaria Bioscience Corp. (NASDAQ: LEXX) is developing emerging technology that promotes faster delivery of drugs into the bloodstream, among other patented innovative health initiatives, making the ...
- Youngwood man to remain in jail to await drug delivery resulting in death trialon March 2, 2021 at 1:30 pm
A Youngwood man will remain in jail to await trial on a charge that he delivered drugs to a woman who died from an overdose in August 2019. Matthew Thomas Caughey pleaded for his release during a cour ...
- Computational modelling of nanotube delivery of anti-cancer drug into glutathione reductase enzymeon March 2, 2021 at 8:48 am
Density functional theory method combined with docking and molecular dynamics simulations are used to understand the interaction of carmustine with human glutathione reductase enzyme. The active site ...
- ScPharmaceuticals plots refiling of twice-rejected on-body drug delivery producton March 2, 2021 at 7:34 am
The company expects to be ready to refile once it has completed work including modified bench tests on aged commercial units of its on-body drug delivery system. Furoscix is designed to give patients ...
via Bing News