via Wikipedia
Experiments in fruit flies show increased lifespan thanks to a combination of probiotics and an herbal supplement
You are what you eat. Or so the saying goes. Science now tells us that we are what the bacteria living in our intestinal tract eat and this could have an influence on how well we age. Building on this, McGill University scientists fed fruit flies with a combination of probiotics and an herbal supplement called Triphala that was able to prolong the flies’ longevity by 60 % and protect them against chronic diseases associated with aging.
The study, published in Scientific Reports, adds to a growing body of evidence of the influence that gut bacteria can have on health. The researchers incorporated a symbiotic – made of probiotics with a polyphenol-rich supplement – into the diet of fruit flies.
The flies fed with the synbiotic lived up to 66 days old – 26 days more than the ones without the supplement. They also showed reduced traits of aging, such as mounting insulin resistance, inflammation and oxidative stress.
“Probiotics dramatically change the architecture of the gut microbiota, not only in its composition but also in respect to how the foods that we eat are metabolized,” says Satya Prakash, professor of biomedical engineering in McGill’s Faculty of Medicine and senior author of the study. “This allows a single probiotic formulation to simultaneously act on several biochemical signaling pathways to elicit broad beneficial physiological effects, and explains why the single formulation we present in this paper has such a dramatic effect on so many different markers”.
The fruit fly is remarkably similar to mammals with about 70 % similarity in terms of their biochemical pathways, making it a good indicator of what would happen in humans, adds Prakash.
“The effects in humans would likely not be as dramatic, but our results definitely suggest that a diet specifically incorporating Triphala along with these probiotics will promote a long and healthy life.”
The authors also say that the findings can be explained by the “gut-brain axis,” a bidirectional communication system between microorganisms residing in the gastrointestinal tract – the microbiota – and the brain. In the past few years, studies have shown the gut-brain axis to be involved in neuropathological changes and a variety of conditions such as irritable bowel syndrome, neurodegeneration and even depression. Few studies, however, have successfully designed gut microbiota-modulating therapeutics having effects as potent or broad as the formulation presented in the new study.
Learning from traditional medicine
The herbal supplement used in the study, Triphala, is a formulation made from amalaki, bibhitaki and haritaki, fruits used as medicinal plants in Ayurveda, a form of traditional Indian medicine.
Susan Westfall, a former PhD student at McGill and lead author of the study, says the idea of combining Triphala and probiotics comes from her long-standing interest in studying natural products derived from traditional Indian medicine and their impact on neurodegenerative diseases.
“At the onset of this study, we were hopeful that combining Triphala with probiotics would be at least a little better than their individual components in terms of physiological benefit, but we did not imagine how successful this formulation would be,” says Westfall, who is now a postdoctoral fellow at the Icahn School of Medicine at Mount Sinai in New York, USA.
The new study, which includes data filed in a US provisional patent through a company cofounded by the authors, has the potential to impact the field of the microbiome, probiotics and human health.
Considering the broad physiological effects of this formulation shown in the fruit fly, Prakash hopes their formulation could have interesting applications in a number of human disorders such as diabetes, obesity, neurodegeneration, chronic inflammation, depression, irritable bowel syndrome and even cancer.
Learn more: The secret to longevity is in the microbiome and the gut
The Latest on: Longevity
via Google News
The Latest on: Longevity
- Pocatello woman turning 101, credits longevity to organic foodon May 27, 2022 at 11:49 am
Rainey, who turns 101 on Saturday, attributes her longevity to her organic diet. "We grew up on organic food and didn't know it," Rainey said. Farming was a large part of Rainey's life, but the ...
- ALL ABOUT DOGS: For health and longevity, reconsider Fluffy's dieton May 27, 2022 at 3:05 am
So why do I put so much attention and intention on what I feed my dog? One reason: Longevity. We know up front (most of the time anyway), we're going to outlive our dog. I believe that spending ...
- AgelessRx Launches New Blog Focused on Longevity and Aging Preventionon May 26, 2022 at 11:01 am
Aging is a phase that everyone goes through but for most, the impact of this natural process is seen earlier than others. Aging has numerous effects on ...
- The Making of a 100-Point Wine: A Brunello with Longevity from a Historic Produceron May 25, 2022 at 4:06 am
Brunello 2016 Report: Finesse, Longevity and the Elephant in the Room Conti Costanti’s 2016 Riserva, on the other hand, showed the quintessential class, pedigree and longevity that has made the ...
- How to live longer: How you can sleep better, feel good, and enhance longevityon May 25, 2022 at 12:20 am
THERE are several ways to live a longer life. The two most commonly suggested are to exercise regularly and to eat a healthy and balanced diet. However, new research suggests it isn't just what a ...
- 12 Foods Rich in Polyphenols, a Powerful Anti-Inflammatory Agent Linked to Longevityon May 24, 2022 at 8:01 am
Longevity is a hot topic that has become even hotter in light of the pandemic these last few years. Many of those particularly invested in researching how to live a long, healthy life naturally ...
- Longevity finance- challenges and opportunitieson May 22, 2022 at 3:55 am
The population around the world is aging, retired, and has a great life expectancy than the previous generation due to the advancement in medical and the availability of resources.
- Pusha-T Talks Longevity in Rap: 'I Can Do This Forever'on May 20, 2022 at 1:53 pm
Pusha-T knows that rap is often seen as a young man’s game, but in a new interview he’s making it clear that he’s absolutely in it for the long haul.
- Longitude Exchange & Dedomainia collaborate on index-based longevity hedgeson May 19, 2022 at 2:55 am
Longitude Exchange, the Bermuda-based digital marketplace for trading in index-based longevity risk, and Dedomainia, a technology company offering ...
via Bing News