James Cook University scientists have discovered a technique to apply natural plant extracts such as Tea Tree Oil as a coating for medical devices, a process which could prevent millions of infections every year.
Professor Mohan Jacob, Head of Electrical and Electronics Engineering at JCU, leads a team investigating the problem. He said an increasing number of unplanned surgeries are being performed to fight infections – mostly caused by bacterial activity on medical devices and a subsequent ‘biofilm’ forming on them.
“Just in the US, about 17 million new biofilm-related infections are reported annually, leading to approximately 550,000 fatalities each year. It’s thought about 80% of worldwide surgery-associated infections may relate to biofilm formation,” he said.
Professor Jacob said the team converted plant-based products – known as Plant Secondary Metabolites (PSMs) – into polymer coatings for medical devices, including implants.
“They’re derived from such things as essential oils and herb extracts and they have relatively powerful broad-spectrum antibacterial activities. PSMs are a low-cost renewable resource available in commercial quantities, with limited toxicity, and potentially, different mechanisms for fighting bacteria than synthetic antibiotics.”
Professor Jacob said the group’s research tackled the persistent problem of how to convert the plant extracts from a liquid to a solid state as a coating for medical devices, without a significant loss of effectiveness.
Dr Katia Bazaka is an Adjunct Senior Research Fellow and team member. “We used plasma-enhanced techniques within a reactor containing the essential oil vapours. When the vapours are exposed to a glow discharge, they are transformed and settle on the surface of an implant as a solid biologically-active coating. These have shown good antibacterial properties,” she said.
“The main advantage of this approach is that we are not using other chemicals, such as solvents, during the fabrication process. As such, there is no threat of potentially harmful chemicals being retained in the coating or them damaging the surface of the material onto which the coating is applied. It also makes the fabrication process more environmentally friendly,” said Dr Bazaka.
Professor Jacob said the JCU group are currently the global pioneers in the development of plant-derived polymer thin films – publishing over 70 research articles and six PhD theses in the field.
Professor Ian Atkinson, Director of JCU’s eResearch unit and a collaborator on the project, said the work had recently been extended to target marine organisms, to prevent the growth of biofilms on aquatic sensors and their subsequent failure.
“Another attractive feature of these coatings is their optical transparency, which may be quite important if you are using them to coat contact lenses, or optical windows in aquatic sensors,” he said.
Professor Jacob and his PhD students are now collaborating with the Dr Peter Mulvey and Associate Professor Jeff Warner at the JCU-based Australian Institute of Tropical Health and Medicine to study the activity of different types of bacteria on the plant- based coatings.
Even though synthetic antibiotics have been the best weapon for eradicating microbial infections since the arrival of penicillin, the overuse of these medications is gradually rendering them ineffective. Scientists think that if new strategies are not developed soon, medical treatments could retreat to the era where slight injuries and common infections develop into serious medical problems.
Most plants produce organic molecules as antimicrobial agents to combat harmful microorganisms. In the past few decades, progress in the synthesis of nanoscale materials, in particular plasma-assisted fabrication, has provided the means to retain the antimicrobial activities of plant secondary metabolites within bioactive coatings.
Though the JCU team investigated many natural precursors, their main focus was on the Australian based essential oil, Tea Tree Oil (Melaleuca alternifolia) and its components. As part of a PhD project, Dr Katia Bazaka developed antibacterial coatings from terpene-4-ol, which is a major component of Tea Tree Oil.
The Latest on: Biofilm-related infections
via Google News
The Latest on: Biofilm-related infections
- Antibiotic-Resistant Biofilm Survives Silver Bulleton October 13, 2021 at 5:02 am
including hospital-related infections, arise due to the growth of stable bacterial biofilms that attach to the surfaces of wounds, ventilators, intravenous and urinary catheters, cardiac ...
- Nanosilver no ‘silver bullet’ in long-term treatment of infectionson October 12, 2021 at 10:03 am
growing biofilms, which can be difficult to control. University of Technology Sydney. "Nanosilver no ‘silver bullet’ in long-term treatment of infections: A popular treatment for microbial ...
- Nanosilver is not a 'silver bullet' in long-term treatment of infectionson October 11, 2021 at 7:11 am
New research from the University of Technology Sydney (UTS) has found that pathogens that form biofilms can evolve ... can increase the risk of recurrent infections. The research is published ...
- Study: Berberine, A Natural Anti-Staphylococcal Agent, Can Be Used To Treat Prosthetic Joint Infectionson October 11, 2021 at 5:35 am
Study: Berberine, A Natural Anti-Staphylococcal Agent, Can Be Used To Treat Prosthetic Joint Infections. News Target \| Natural News. October 11th, 2021 \| 16 ...
- Nanosilver no 'silver bullet' in long-term treatment of infectionson October 10, 2021 at 11:45 pm
The study is the first to demonstrate that long-term nanosilver treatment can increase the risk of recurrent infections. The research is published in the Journal of Nanobiotechnology ("Evolution of ...
- Want Improved Medical Treatment? How About Custom-Designed Patient Therapieson October 10, 2021 at 5:00 pm
developed a computer algorithm that can design and manufacture 3D-printed objects comprised of two polymer materials of differing stiffness that also prevent the build-up of bacterial biofilm. Related ...
- Hospital superbugs can be destroyed by 'engineered' bacteria that fight infections transmitted through catheters and breathing tubes, research suggestson October 7, 2021 at 1:11 am
The results are very promising and welcome as biofilm infections can cause sepsis and death, particularly in intensive care units. However, there is a long and expensive path ahead to see if the ...
- Antibiotic-Resistant Biofilms Eliminated by “Living Medicine”on October 6, 2021 at 10:45 am
S. aureus is one of the most common species of biofilm-associated bacteria. S. aureus infections do not respond to conventional antibiotics, requiring patients to surgically remove any infected ...
- 'Living medicine' created to treat drug-resistant infectionson October 6, 2021 at 8:52 am
Staphylococcus aureus is one of the most common species of biofilm-associated bacteria. S. aureus infections do not respond to conventional antibiotics, requiring patients to surgically remove any ...
via Bing News