A silk hybrid material attacks bacteria when illuminated by a green light, thanks to a far-red fluorescent protein researchers transferred to its genetic makeup.
The all-natural material would be safer than conventional photocatalytic, or light-activated, means to kill harmful pathogens such as bacteria, which use potentially biohazardous semiconductors and require cancer-causing ultraviolet light for activation. A silk alternative engineered by Purdue University and the Korean National Institute of Agricultural Research would instead use plasmonic photocatalyst-like biomaterials and visible light, which also aid in wound healing and environmental remediation including air and water purification. Their findings published in early view on March 12 in Advanced Science.
“Silk is an ancient and well-known biomaterial,” said Young Kim, Purdue associate professor of biomedical engineering. “It doesn’t have any issues with the human body. And the nice thing about green light is that it’s not harmful – the color corresponds to the strongest intensity of the solar spectrum.”
To combine the benefits of silk and green light, researchers inserted the gene for “mKate2,” a far-red fluorescent protein, into a silk host. Shining a green light on the resulting hybrid generates reactive oxygen species (ROS), which are effective radicals for breaking down organic contaminants and attacking the membrane and DNA of pathogens.
When E. coli on the fluorescent silk were illuminated by a weak green light for 60 minutes, the bacteria’s survival rate dropped to 45 percent.
The researchers found that the hybrid could be processed into a solution, film, bandage and fabric. “We’ve basically added fluorescence to silk to facilitate disinfection or decontamination using just visible light,” said Jung Woo Leem, a visiting scholar in Purdue’s school of biomedical engineering.
Kim’s team believes that green-light activated red fluorescent silk could be both more efficient and scalable than other plasmonic photocatalysts, in which metal nanoparticles hybridized from semiconductor materials also use visible light but could still pose negative environmental consequences.
“The silk photocatalysts would be easier and safer to produce than plasmonic ones since silkworms, rather than industrial facilities, provide the host for ROS-generating materials. It’s a completely new green manufacturing of nanomaterials,” Kim said.
Because ambient white light also includes green light, the researchers anticipate that the silk hybrid material should typically have a strong enough light source to generate ROS as long as a green light controls ROS generation.
Kim’s team plans to take advantage of silk’s biocompatibility with the human body both inside and out. “We’re thinking about some implantable and injectable wound healing materials that dissolve over time in the body. Then we wouldn’t need to do additional surgery to take it out,” Kim said.
The Latest on: Wound healing
via Google News
The Latest on: Wound healing
- Seaweed molecules found to aid wound healingon April 9, 2021 at 7:30 am
"Wound healing occurs in a 3D environment involving a number of cell types and biomolecules, so the use of 3D bioprinting to create scaffolds for wound healing has attracted much attention ...
- Growing Demand for Faster Recovery of Wounds is Driving Advancements in the European Advanced Wound Care Marketon April 9, 2021 at 1:58 am
problems associated with ineffective traditional wound healing methods, initiatives taken by the government, and a pressing need for swift and safer treatment of chronic wounds. According to ...
- Spectral MD Announces BARDA Approval of Additional Funding of $20.6 Million to Execute DeepView Training Clinical Study for Burn Woundson April 7, 2021 at 10:00 am
Spectral MD announced today the execution of Option 1A of its contract with the Biomedical Advanced Research and Development Authority (BARDA), which will provide Spectral MD with an additional $20.6 ...
- Advanced Wound Care Management Market Size Estimated to Reach $16,500 Million by 2026on April 6, 2021 at 3:33 am
Advanced wound care products include foam dressings, hydrogels which is natural healing process and provides helpful wound healing and protection from outside environment. Alginates dressing are ...
- Wounds Measurement Devices Market Size to Grow at a CAGR of 4.7% During the Forecast Period 2021–2026on April 6, 2021 at 1:36 am
Moreover, it is a compulsory procedure to study the progress of wound healing, assessment of wounds and the regular follow-up of wound size are relevant in terms of reimbursements, insurance coverage.
- BU, Harvard create new model to better understand wound healingon April 5, 2021 at 9:30 pm
Researchers from Boston University and Harvard University created a model to better understand how human wounds heal. By using an in-vitro model with human cells, scientists were able to replicate a ...
- Connecting with patients leads to wound care center awardon April 4, 2021 at 9:21 am
Russell Medical Wound Care Center has won another award but not just another award. The wound treatment center is in the top 10% for healing wounds, winning the Healogics’ 2020 Robert Warriner III M.D ...
- Medical Moment: Wound healing gel leaves no scaron April 1, 2021 at 2:35 pm
But as Martie Salt reports, scientists at UCLA have developed a gel that may someday soon make injured areas of skin stronger. The scientists have formed a company to test and develop the ...
- The Wonder Spray: The Revolutionary Germ Killer Being Used for Wound Healing and Many Ailmentson March 31, 2021 at 8:58 pm
When this injury goes unnoticed or untreated it can have dire consequences, including amputation. Dr. Burd had been looking for a solution for wound healing for years when he discovered Wonder Spray.
via Bing News