
This glowing contact lens could help prevent blindness in millions of people with diabetes.
Credit: Caltech
Worn during sleep, the lens interrupts the process that destroys cells of the retina
Hundreds of millions of people suffer from diabetes worldwide, putting them at risk for a creeping blindness, or diabetic retinopathy, that comes with the disease in its more advanced stages. Existing treatments, though effective, are painful and invasive, involving lasers and injections into the eyeball. Caltech graduate student Colin Cook (MS ’16) thinks there’s a better way.
Cook, along with a group of researchers from the lab of Yu-Chong Tai, Caltech’s Anna L. Rosen Professor of Electrical Engineering and Medical Engineering, has developed a potential treatment that could be a lot less scary and invasive, in the form of a glow-in-the-dark contact lens.
The loss of vision that accompanies diabetes is the result of the damage the disease causes to tiny blood vessels throughout the body, including those in the eye. That damage results in reduced blood flow to the nerve cells in the retina and their eventual death. As the disease progresses, the body attempts to counteract the effects of the damaged blood vessels by growing new ones within the retina. In diabetes patients, however, these vessels tend to be badly developed and bleed into the clear fluid inside the eye, obscuring vision and compounding eyesight problems. As the blood vessels bleed, they cause additional damage to the retina that the body repairs with scar tissue rather than new light-sensing cells. Over time, a diabetic patient’s vision becomes blurry and patchy before fading away completely.
Because damage to the retina begins with an insufficient supply of oxygen, it should be possible to stave off further eyesight loss by reducing the retina’s oxygen demands. Until now, that’s been achieved by using a laser to burn away the cells in the peripheral parts of the retina, so the oxygen those cells would have required can be used by the more important vision cells in the center of the retina. Another treatment requires injecting medication that reduces the growth of new blood vessels directly into the eyeball.
Cook hopes his contact lenses will offer a solution that patients will be more willing to try because the effort involved is minimal, as are the side effects.
Like the laser treatment, the lenses reduce the metabolic demands of the retina, but in a different fashion. Key to their success are the eye’s rod cells, which provide vision in low-light conditions. The rod cells need and use a lot more oxygen in the dark than they do when they’re awash with light—while, say, looking at this computer screen—and it has been hypothesized for two decades that much of the damage caused to the retina by diabetic retinopathy occurs when the rod cells crank up their oxygen demands at night.
“Your rod cells, as it turns out, consume about twice as much oxygen in the dark as they do in the light,” Cook says.
For that reason, the contact lenses are designed to reduce the retina’s night-time oxygen demand by giving the rod cells the faintest amount of light to look at while the wearer sleeps.
“If we turn metabolism in the retina down, we should be able to prevent some of the damage that occurs,” he says.
To provide light to the retina throughout the night, the lenses borrow technology from wristwatches that have glowing markers on their faces. The illumination is provided by tiny vials filled with tritium, a radioactive form of hydrogen gas that emits electrons as it decays. Those electrons are converted into light by a phosphorescent coating. This system ensures a constant light output for the lifetime of the contact lens.
The vials, which are only the width of a few human hairs, are implanted in the lens in a radial pattern like the rays of a cartoon sun. The vials create a circle that is just big enough to fall outside of the wearer’s view when the pupils are constricted in lighted conditions. In the dark, the pupil expands, and the faint glow from the vials can illuminate the retina.
Light therapy for diabetic retinopathy has been attempted before in the form of lighted sleep masks, but results were poor, partly because patients had difficulty tolerating the masks and ignoring the light shining into their eyes as they slept.
The sleep mask light source is not affixed to the eye, so as the eye moves, the wearer sees a flicker and that’s very distracting as you’re trying to fall asleep, he says.
Cook says his lenses avoid that problem by placing the light source on the surface of the eye, so when the eye moves, the light source moves with it, and there is no flicker for the wearer to notice.
“There’s neural adaptation that happens when you have a constant source of illumination on the eye. The brain subtracts that signal from the vision and the wearer will perceive dark again in just a few seconds,” he says.

The contact lens as it appears in lighted and dark conditions.
The contact lens design also ensures that the retina receives an appropriate dose of light throughout the night.
“As we sleep, our eyes roll back. For a sleep mask this means the eye is no longer receiving as much light, but the contact lenses move with the eye, so there is no such problem,” he says.
Early testing of the lenses conducted in collaboration with Mark Humayun’s lab at the University of Southern California is showing promising results, with rod cell activity reduced by as much as 90 percent when worn in the dark. Cook says in the next few months, he and his fellow researchers will start testing the lenses to see if their ability to reduce retinal metabolism will translate into the prevention of diabetic retinopathy. Following those tests, they will seek FDA permits to begin clinical trials.
“This is an innovative solution with a potentially huge impact on diabetic retinopathy,” says Tai, who also holds the Andrew and Peggy Cherng Medical Engineering Leadership Chair and is executive officer for medical engineering.
Learn more:Â Glowing Contact Lens Could Prevent A Leading Cause of Blindness
The Latest on: Diabetic retinopathy
[google_news title=”” keyword=”diabetic retinopathy” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Diabetic retinopathy
- Why Is Ocuphire Pharma (OCUP) Stock Down 20% Today?on January 26, 2023 at 7:02 am
Ocuphire Pharma (OCUP) stock is falling on Thursday after the company posted mixed results from a Phase 2 clinical trial.More From InvestorPlace Buy This $5 Stock BEFORE This Apple Project Goes Live ...
- Oral drug for diabetic retinopathy flunks PhII, but biotech wants to go into PhIII with new endpointon January 26, 2023 at 4:03 am
When you’re trying to develop the first oral treatment for diabetic patients with eye disease, a Phase II flop need not be the end of the road — at least according to Ocuphire Pharma. The Farmington ...
- Researchers Unravel Why Episodes of Low Blood Sugar Worsen Eye Disease in People with Diabeteson January 26, 2023 at 1:00 am
Artistic rendition of an immunofluorescent image of a mouse retina taken during a transient episode of low serum glucose demonstrating accumulation of a protein, Hypoxia Inducible Factor (HIF)-1 alpha ...
- Ocuphire Announces Topline Results from ZETA-1 Phase 2 Trial of Oral APX3330 in Diabetic Retinopathy and Plans for End-of-Phase 2 Meeting with FDAon January 25, 2023 at 2:22 pm
Oral APX3330 Achieved Statistical Significance on a Key Pre-specified Secondary Endpoint of Preventing Clinically Meaningful Progression of Diabetic Retinopathy (DR) after 24 Week ...
- Ocuphire Pharma Shares Drop 31% After Hours After Diabetic Retinopathy Drug Study Resultson January 25, 2023 at 1:01 pm
By Kathryn Hardison Shares of Ocuphire Pharma Inc. dropped 31% to $2.60 in after-hours trading on Wednesday after it said its treatment for ...
- Eye Check Important Before Starting Semaglutide for Diabeteson January 24, 2023 at 10:04 am
A small potential increased risk of retinopathy worsening at 1 year with injected semaglutide (Ozempic, Novo Nordisk), a glucagon-like peptide 1 (GLP-1) agonist approved for type 2 diabetes, doesn't ...
- Diabetes: Is it safe for diabetics to undergo cataract surgery?on January 23, 2023 at 4:49 pm
Diabetes is a common lifestyle disease, which can take a toll on other organs and systems of your body. It can even affect vision and eye health. According to research, people suffering from diabetes ...
- Diabetic Retinopathy (DR) Analysis Software Market 2023 Advance Technology, Latest Trend and Future Expansion by 2028on January 19, 2023 at 5:58 pm
Final Report will add the analysis of the impact of Russia-Ukraine War and COVID-19 on this Diabetic Retinopathy (DR) Analysis Software Industry. " Diabetic Retinopathy (DR) Analysis Software Market " ...
- Researchers reveal diabetic retinopathy cause blindness in adultson January 15, 2023 at 4:03 am
Diabetic retinopathy, which results in progressive damage to the blood vessels in the light-sensitive tissue at the back of the eye, is the main cause of blindness in adults in the United States.
via Bing News