Stanford scientists have found a cell that creates the two different compartments in the mouse lung. They hope their discovery could lead to better therapies for people with lung disease.
A researcher at the School of Medicine and his colleagues have succeeded in isolating mouse lung stem cells, growing them in large volumes and incorporating them into injured lung tissue in mice.
The work raises hopes for regenerative therapies that could heal currently intractable lung diseases.
A study describing the research was published online Nov. 6 in Nature Methods. Kyle Loh, PhD, an investigator at the Stanford Institute for Stem Cell Biology and Regenerative Medicine, and Bing Lim, MD, PhD, an investigator at the Genome Institute of Singapore, share senior authorship. The lead author is Massimo Nichane, PhD, currently a research scientist at the Stanford stem cell institute.
The lungs are among the most vital organs of the body. In conjunction with the cardiovascular system, they allow air to travel to every cell and get rid of the waste products of respiration, such as carbon dioxide. For many people with end-stage lung diseases, the only option is lung transplantation.
“Scientists have previously had little success in putting new lung cells into damaged lung to regenerate healthy tissue,” Loh said. “We decided to see if we could do that in an animal model.”
The researchers started by working to improve on current knowledge of lung stem cells. The lung is divided into two compartments, Loh said: the airway, which allows for passage of air in and out of the lung; and the alveoli, where gases pass in and out of the blood. Other researchers had previously isolated one stem cell for the airway and another stem cell for the alveoli. Loh and his colleagues searched for and found a single lung stem cell that could create cells in both the airway and the alveoli. These multipotent lung stem cells were typified by their display of a protein marker called Sox9.
From one to 100 billion billion
Once they had isolated the stem cells, they were able to make them multiply dramatically. Each mouse lung stem cell that they start started with was able to grow into 100 billion billion lung stem cells over the course of six months. Previously, researchers had not had much success expanding any lung stem cell populations in the laboratory.
Finally, they injected the stem cells into mouse lungs that had been injured by a variety of toxins. “What we saw was that these multipotent stem cells repaired the injured tissue and were able to differentiate into the many different kinds of cells that make up the healthy lung,” said Nichane.
“Our newfound ability to grow these mouse multipotent lung stem cells in a petri dish in very large numbers, and the cells’ ability to regenerate both lung airway and alveolar tissue, constitutes a first step towards future lung regenerative therapies,” Loh said. “Future work will focus on whether analogous multipotent stem cells can be found and cultivated from humans, which may open the way to eventually replenishing damaged lung tissue in the clinic.”
The Latest on: Lung injury
via Google News
The Latest on: Lung injury
- ‘Worst pain I’ve been in, ever’: Eel overcomes injury as Sivo returnson May 22, 2022 at 3:29 pm
Parramatta are suddenly spoiled for choice, with wingers with Maika Sivo back and Sean Russell detailing the pain he felt from busted ribs and a punctured lung.
- One year after suffering injury that could've killed him, Cam Gaddis is back home with Tucsonon May 20, 2022 at 3:45 pm
The Santa Rita High School grad said the thought of not playing the sport he fell in love with in the eighth grade was "heartbreaking and depressing." ...
- This imaging tool provides more precision in lung canceron May 20, 2022 at 12:01 pm
Although many people would have been diagnosed with Covid-19 itself, there are also a handful of patients who were found to have lung cancer. According to the latest cancer registries, lung cancer is ...
- Drug developed for lung diseases shows great results in mice with spinal cord injurieson May 20, 2022 at 10:42 am
Spinal injuries are quite common in the United Kingdom and if the testing is successful, the drug can also be used to treat conditions such as osteoarthritis.
- University of Edinburgh: Pandemic Science Hub to fight lung diseaseon May 19, 2022 at 9:20 pm
A new multi-million pound research programme to develop treatments for lung infections such as Covid-19 and future pandemics has been announced at the University of Edinburgh with support from a ...
- The Baillie Gifford Pandemic Science Hub launched to fight lung diseaseon May 19, 2022 at 5:32 am
Gifford is supporting the launch with a philanthropic donation of £14.7m. A new multi-million-pound pandemic science hub is being created, to develop treatments for lung infectio ...
- Pandemic Science Hub to develop better drugs to fight lung diseaseon May 18, 2022 at 6:54 am
Pandemic Science Hub to develop better drugs to fight lung diseaseA new multi-million pound research programme to develop treatments for lung infections such as Covid-19 and future pandemics has been ...
- Pandemic science hub established to develop drugs for lung infectionson May 18, 2022 at 5:36 am
A new pandemic science hub is being created in the UK to develop treatments for lung infections such as Covid-19 and similar future pandemics.
- Pandemic science hub will develop drugs for lung infections such as Covid-19on May 18, 2022 at 5:36 am
A new pandemic science hub is being created to develop treatments for lung infections such as Covid-19. The hub at the University of Edinburgh will use translational genomics – following clues from ...
- First-Ever Millennial Lung Health Study Begins in Chicagoon May 11, 2022 at 9:00 am
Lung disease is now a leading cause of death in the country due to the increase in COVID-19 infections and related deaths. At a time when lung health is more important than ever, today, the American ...
via Bing News