Scientists have discovered a new metabolic process in the body that can switch off inflammation. They have discovered that ‘itaconate’ – a molecule derived from glucose – acts as a powerful off-switch for macrophages, which are the cells in the immune system that lie at the heart of many inflammatory diseases including arthritis, inflammatory bowel disease and heart disease.
The scientists, working in the School of Biochemistry and Immunology in the Trinity Biomedical Sciences Institute at Trinity College Dublin, hope their discovery will have relevance for inflammatory and infectious diseases – and that their findings may also help to develop much-needed new drugs to treat people living with these conditions.
Professor of Biochemistry at Trinity, Luke O’Neill, was, along with Dr Mike Murphy of the University of Cambridge, the joint leader of the work just published in leading international journal Nature. The discoveries were made using both human cells and mice as a model organism.
Professor O’Neill said: “My lab has been exploring metabolic changes in macrophages for the past six years and we’ve come across what we think is the most important finding yet.”
“It is well known that macrophages cause inflammation, but we have just found that they can be coaxed to make a biochemical called itaconate. This functions as an important brake, or off-switch, on the macrophage, cooling the heat of inflammation in a process never before described.”
Dr Evanna Mills, who, with Dylan Ryan was joint first author of the work, said: “The macrophage takes the nutrient glucose, whose day job it is to provide energy, and surprisingly turns it into itaconate. This then blocks production of inflammatory factors, and also protects mice from the lethal inflammation that can occur during infection.”
Dylan Ryan added: “We’ve found that itaconate can directly modify a whole host of proteins important for inflammation in a chemical reaction never before described, and that this reaction is important for the anti-inflammatory effects of itaconate.”
The discovery is very much on the frontier of inflammation research and Professor O’Neill and his collaborators are now exploring its relevance to the onset and development of inflammatory and infectious diseases. They are also keen to explore whether the findings can be exploited in the effort to develop new anti-inflammatory medicines.
The work was a collaboration with Harvard Medical School, the University of Cambridge, the University of Oxford, Johns Hopkins University, the University of Dundee, and GlaxoSmithKline, where both Professor O’Neill and Dr Mills spent time on sabbatical.
Professor O’Neill said: “This discovery and the new research pathways it has opened up will keep us busy for some time but we are hopeful that it will one day make a difference to patients with diseases that remain difficult to treat.”
The Latest on: Inflammation
via Google News
The Latest on: Inflammation
- Research Shows Eating Berries Can Help Reduce Inflammation And Health Risks Caused By Obesityon June 24, 2022 at 3:58 am
Research Shows Eating Berries Can Help Reduce Inflammation And Health Risks Caused By Obesity. News Target \| Natural News. June 24th, 2022 \| 18:40 PM \| 8 vi ...
- This Derm-Approved Toner Locks in Moisture While Soothing Inflammation—And It Feels So Good, I Keep a Bottle in My Caron June 23, 2022 at 3:00 pm
“Dermalogica’s toner has aloe, which is a wonderful ingredient to bring down inflammation. And it’s especially helpful if you have rosacea,” says Magovern. It’s also formulated with, “arnica, lavender ...
- Novel drug molecule targets T-cells causing inflammation in heart failure patientson June 22, 2022 at 4:30 pm
Researchers at The Ohio State University Wexner Medical Center and College of Medicine have developed a novel drug molecule that targets T-cells causing inflammation in heart failure patients, ...
- Epidermal CXCL14 may play a protective role in skin inflammation in miceon June 21, 2022 at 9:33 am
Researchers at Kyoto University have discovered the skin's natural protection from nighttime bacterial invasion in mice, which may provide a basis for eventually developing a drug treatment.
- The #1 Best Supplement to Reduce Inflammation, Say Expertson June 18, 2022 at 3:44 am
Inflammation is vital in helping our immune system protect us from sickness and infection, but when our body produces too much it can be harmful to our health and cause major issues like heart disease ...
- Is CBD or CBG Better for Pain and Inflammation?on June 17, 2022 at 1:47 pm
CBD isn’t the only cannabinoid people use for pain anymore. Over the last years, CBG has become nearly as popular, leaving many hemp users wondering which cannabinoid is more effective against pain ...
- Examining the mechanism by which active inflammation occurs in parallel with immunosuppression in the TMEon June 17, 2022 at 9:53 am
If cancerous cells started wreaking havoc in your body, like terrorists in a building, your immune system would act like a SWAT team to combat the enemy. But what if the building entrance were blocked ...
- 7 Worst Breads to Eat for Inflammation, Say Dietitianson June 16, 2022 at 10:29 am
Bread is not created equally. Whole grain bread can be healthy, but many other types of bread can contribute to inflammation.
- Flying Under The Radar: How SARS-CoV-2 ORF7a Contributes To Immune Evasion And Inflammationon June 16, 2022 at 10:17 am
SARS-CoV-2 has a variety of accessory proteins that help it evade and suppress our immune system. Recent findings suggest that the accessory protein ORF7a helps suppress our immune cells, making it ...
via Bing News