In a rare move, a Houston Methodist researcher is sharing his recipe for a new, more affordable way to make nanoparticles. This will empower any laboratory in the world to easily create similar nanoparticles and could lead to a whole new way of delivering biotherapeutic drugs and do it more quickly.
“We’re the only lab in the world doing this,” said Ennio Tasciotti, Ph.D., director of the Center for Biomimetic Medicine at the Houston Methodist Research Institute and corresponding author on a paper coming out March 7 in Advanced Materials. “There are several questions about how our system works, and I can’t answer all of them. By giving away the so-called ‘recipe’ to make biomimetic nanoparticles, a lot of other labs will be able to enter this field and may provide additional solutions and applications that are beyond the reach of only one laboratory. You could say it’s the democratization of nanotechnology.”
In the article, Tasciotti and his colleagues show how to standardize nanoparticle production to guarantee stability and reproducibility, while increasing yield. Eliminating the need for multi-million-dollar facilities, Tasciotti and his team demonstrate this using a readily available and relatively affordable piece of benchtop equipment to manufacture nanoparticles in a controlled, adjustable and low-cost manner.
“Nanoparticles are generally made through cryptic protocols, and it’s very often impossible to consistently or affordably reproduce them,” Tasciotti said. “You usually need special, custom-made equipment or procedures that are available to only a few laboratories. We provide step-by-step instructions so that now everybody can do it.”
For decades nanoparticles have been made out of bioinert, or inorganic, substances that don’t interact with the body. In more recent years, nanoparticles were made to be bioactive, meaning they could respond to the environment. Now, Tasciotti is pushing the field forward by creating biomimetic nanoparticles that resemble cell composition and work in synergy with the laws that govern the physiology of the body.
“The body is so smart in the ways it defends itself. The immune system will eventually recognize nanoparticles no matter how well you make them,” Tasciotti said. “In my lab, we make nanoparticles out of the cell membrane of the very same immune cells that patrol the blood stream. When we put these biomimetic, or bioinspired, nanoparticles back in the body, the immune cells do not recognize them as something different, as they’re made of their same building blocks, so there is no adverse response.”
Despite the complexity of this new class of particles, Tasciotti says it’s incredibly simple how they put it together, which is why he decided to publish this paper.
“While our lab will remain fully devoted to this line of research, if somebody else develops some solutions using our protocols that are useful in clinical care, it’s still a good outcome,” he said. “After all, the ultimate reason why we are in translational science is for the benefit of the patients.”
The Latest on: Biomimetic nanoparticles
[google_news title=”” keyword=”Biomimetic nanoparticles” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Biomimetic nanoparticles
- Of Nanobacteria, Nanoparticles, Biofilms and Their Role in Health and Disease: Facts, Fancy and Futureon February 23, 2024 at 4:00 pm
mineralo-organic nanoparticles (NPs) with biomimetic properties. These mineralo-organic NPs resemble biological lifeforms like bacteria in terms of morphology, growth, proliferation and subculture.
- Biomimetic signals ‘provide better communication between prostheses and brain’on February 21, 2024 at 8:42 am
Designed to highlight the benefits of naturally inspired, biomimetic stimulation for the next generation of ‘neuroprosthetics’, the tests were carried out by Professor Stanisa Raspopovic and his team ...
- Nanoparticles enhance locusts’ sense of smellon February 20, 2024 at 4:00 pm
Hot spots: this photo composition has a locust (centre) showing the location of the nanoparticles (left), which are illuminated by near-infrared light (illustrated in red). (Courtesy: Singamaneni ...
- The role of interparticle and external forces in nanoparticle assemblyon February 20, 2024 at 7:06 am
One may, however, distinguish between isolated nanoparticles, nanostructured biosurfaces and nanostructured biological materials (as well as 'biomaterials', which are biomimetic rather than ...
- Nanoparticles and the Blood Coagulation Systemon February 18, 2024 at 4:00 pm
As such, nanoparticles are rapidly entering various areas of industry, biology and medicine. The benefits of using nanotechnology for industrial and biomedical applications are often tempered by ...
- Celadyne coats membranes with nanoparticles to make hydrogen fuel cells more efficienton February 15, 2024 at 5:59 am
One startup thinks it has a solution for both sides. Chicago-based Celadyne has developed a nanoparticle coating that can be applied to existing fuel cell and electrolyzer membranes. The material ...
- Biomimetic hydrogel could help cancer researchon February 15, 2024 at 3:00 am
A new type of fibrous hydrogel derived from wood could be used to improve cancer treatments and heal damaged heart tissue.
- Inhalable nanoparticles could help treat chronic lung diseaseon February 6, 2024 at 4:00 pm
Delivering medication to the lungs with inhalable nanoparticles may help treat chronic obstructive pulmonary disease (COPD). In mice with signs of the condition, the treatment improved lung ...
- Building a DNA nanoparticle to be both carrier and medicineon February 6, 2024 at 2:19 am
AMES, Iowa – Scientists have been making nanoparticles out of DNA strands for two decades, manipulating the bonds that maintain DNA’s double-helical shape to sculpt self-assembling structures that ...
- Researchers develop biomimetic-photo-coupled catalysis for H₂O₂ productionon February 5, 2024 at 8:48 am
The strategy involves loading gold nanoparticles (AuNPs ... As a result, both the biomimetic catalytic and photocatalytic reduction of O 2 to H 2 O 2 are enhanced, achieving a significant ...
via Bing News