A microRNA that regulates inflammation shows promise as a treatment for inflammatory diseases such as asthma and cancer, according to research published in Cell Reports.
The microRNA, known as miR-223, is highly expressed in blood cells that cause inflammation (neutrophils). When they’re working correctly, those blood cells help protect the human body against infections, but sometimes they damage host tissue instead of microbes, causing chronic inflammation and disease.
To uncover the link between miR-223 and inflammation, a Purdue University research team created a zebrafish totally deficient of miR-223. Then they cut off a small chunk of its fin.
“The inflammation was really robust,” said Qing Deng, a professor of biological sciences at Purdue and corresponding author of the paper. “Neutrophils accumulated at the wound and they just kept coming. This is consistent with the literature, but we wanted to understand why.”
Extensive gene expression analysis led them to pathway NF-kB, a protein complex found in nearly all animal cell types that regulates inflammation and cell proliferation. Heightened activation of this pathway is the cause of increased inflammation, although it’s limited to the deeper, or basal, layer of the epithelium. This means any therapeutics would need to reach the basal layer to work.
The same pathway plays an important role in human bronchial epithelial cells, which are critical in the development of asthma, according to the study. MiR-223 suppresses the pathway, which means supplementing it to epithelial cells could help control inflammatory disease.
“We don’t have human trials yet, but we think it’s promising,” Deng said. “Instead of using steroids to drive away the immune cells, maybe this microRNA could be given.”
Learn more: MicroRNA could help treat cancer and asthma
The Latest on: MicroRNA
via Google News
The Latest on: MicroRNA
- MicroRNA-432-5p regulates sprouting and intussusceptive angiogenesis in osteosarcoma microenvironment by targeting PDGFBon April 12, 2021 at 8:50 am
Am J Physiol Cell Physiol. 2017;313:C380–91. Davis BN, Hilyard AC, Nguyen PH, Lagna G, Hata A. Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of ...
- Stool transplants treat bowel infection by boosting bowel-protecting cellson April 9, 2021 at 1:26 pm
Stool transplants effectively treat bacterial infections in the colon by boosting levels of specific molecules that help protect bowel cells, according to a study published Friday by Gastroenterology.
- Widespread and sustained target engagement in Huntington’s disease minipigs upon intrastriatal microRNA-based gene therapyon April 8, 2021 at 11:08 pm
Now, Vallès et al. evaluated the effects of an adeno-associated viral vector (AAV)–mediated strategy delivering microRNA (miRNA) targeting human mutant HTT (mHTT) in a pig model of HD that closely ...
- CSDE1 attenuates microRNA-mediated silencing of PMEPA1 in melanomaon April 8, 2021 at 8:39 am
Br J Cancer. 2012;106:553–61. Aksenenko M, Palkina N, Komina A, Tashireva L, Ruksha T. Differences in microRNA expression between melanoma and healthy adjacent skin. BMC Dermatol. 2019;19:1. Qian H, ...
- MicroRNA Found to Control Late-Stage Brain Developmenton April 8, 2021 at 5:00 am
The discovery that microRNA-29 controls late-stage brain development may lead to new therapeutic approaches for neurodevelopmental conditions.
- Microrna-29 molecule controls brain maturation in mammalson April 7, 2021 at 11:00 pm
A team led by scientists at the UNC School of Medicine identified a molecule called microRNA-29 as a powerful controller of brain maturation in mammals. Deleting microRNA-29 in mice caused ...
- UNC scientists identify a molecule as powerful controller of brain maturation in mammalson April 6, 2021 at 9:12 pm
A team led by scientists at the UNC School of Medicine identified a molecule called microRNA-29 as a powerful controller of brain maturation in mammals. Deleting microRNA-29 in mice caused problems ...
- Key brain molecule may play role in many brain disorderson April 6, 2021 at 2:39 pm
Scientists have identified a molecule called microRNA-29 as a powerful controller of brain maturation in mammals. Deleting microRNA-29 in mice caused problems very similar to those seen in autism, ...
- MicroRNA Market Value Projected To Reach US$ 618.6 Million By 2027: Acumen Research And Consultingon April 6, 2021 at 9:11 am
Segmental Outlook MicroRNA market is segmented as product, services, application, and end-user. By product, the market is bifurcated into instruments and consumables. By services, the market is ...
- MicroRNA Market Size 2021 | To Exhibit Stellar 13.4% CAGR and Hit USD 613.2 Million by 2027on April 5, 2021 at 9:52 pm
Pune, India, April 06, 2021 (GLOBE NEWSWIRE) -- The global microRNA market size is expected to showcase exponential growth by reaching USD 613.2 million by 2027 while exhibiting a CAGR of 13.4% ...
via Bing News