
via Wikipedia
A microRNA that regulates inflammation shows promise as a treatment for inflammatory diseases such as asthma and cancer, according to research published in Cell Reports.
The microRNA, known as miR-223, is highly expressed in blood cells that cause inflammation (neutrophils). When they’re working correctly, those blood cells help protect the human body against infections, but sometimes they damage host tissue instead of microbes, causing chronic inflammation and disease.
To uncover the link between miR-223 and inflammation, a Purdue University research team created a zebrafish totally deficient of miR-223. Then they cut off a small chunk of its fin.
“The inflammation was really robust,” said Qing Deng, a professor of biological sciences at Purdue and corresponding author of the paper. “Neutrophils accumulated at the wound and they just kept coming. This is consistent with the literature, but we wanted to understand why.”
Extensive gene expression analysis led them to pathway NF-kB, a protein complex found in nearly all animal cell types that regulates inflammation and cell proliferation. Heightened activation of this pathway is the cause of increased inflammation, although it’s limited to the deeper, or basal, layer of the epithelium. This means any therapeutics would need to reach the basal layer to work.
The same pathway plays an important role in human bronchial epithelial cells, which are critical in the development of asthma, according to the study. MiR-223 suppresses the pathway, which means supplementing it to epithelial cells could help control inflammatory disease.
“We don’t have human trials yet, but we think it’s promising,” Deng said. “Instead of using steroids to drive away the immune cells, maybe this microRNA could be given.”
Learn more: MicroRNA could help treat cancer and asthma
The Latest on: MicroRNA
via Google News
The Latest on: MicroRNA
- SIx New Anti-Aging Activeson March 1, 2021 at 9:11 am
As we plunge into 2021, I have been rounding up some insights into the anti-aging actives we should have on our radar. There's new research around something called microRNA, a new think on immune ...
- Development of microRNA-based TREATMENTS for MYOTONIC DYSTROPHY Type 1 by Translational Genomics Groupon February 28, 2021 at 7:13 am
Dr. Artero’s Lab, based in Spain (University of Valencia), is a pioneer in discovering therapeutic targets and innovative drug candidates for rare diseases ...
- MicroRNA Testing of Healthy Children Could Provide a Window on Heart and Kidney Health Later in Lifeon February 26, 2021 at 10:20 pm
Molecules called microRNAs (miRNAs) that are measurable in urine have been identified by researchers at Mount Sinai as predictors of both heart ...
- MicroRNA Market Global Trends, Market Share, Industry Size, Growth, Opportunities and Market Forecast 2020 to 2027on February 26, 2021 at 9:50 pm
The MarketWatch News Department was not involved in the creation of this content. Feb 26, 2021 (Market Insight Reports) -- The Global MicroRNA Market is estimated to value over USD 742.6 million by ...
- MicroRNA testing of healthy kids could provide a window on future heart and kidney healthon February 26, 2021 at 8:25 am
Molecules called microRNAs (miRNAs) that are measurable in urine have been identified by researchers at Mount Sinai as predictors of both heart and kidney health in children without disease. The ...
- A novel approach for microRNA in situ hybridization using locked nucleic acid probeson February 24, 2021 at 3:23 am
Identification of target tissue microRNAs (miR) using in situ hybridization (ISH), with digoxigenin-labeled locked nucleic acid (LNA) probes, is influenced by preanalytic parameters. To determine the ...
- MicroRNA-17-3p suppresses NF-κB-mediated endothelial inflammation by targeting NIK and IKKβ binding proteinon February 23, 2021 at 10:24 am
The present study tested the hypothesis that microRNA-17-3p (miR-17-3p) suppresses the pro-inflammatory responses via NF-κB signaling in vascular endothelium. Human umbilical vein endothelial cells ...
- Vetsina Animal Diagnostics seeks investment partneron February 23, 2021 at 5:10 am
Vetsina Animal Diagnostics is seeking investment partners to commercialize its microRNA-based diagnostic tests for the animal health market. Vetsina, formed last year as a joint venture between Roslin ...
- MicroRNA Market Growing at a CAGR of 18.7% | miRNA Industry Analysis, Size, Share, Growth, Trends, and Forecast 2021 - 2027on February 22, 2021 at 9:40 am
Market size is expected to gain market growth in the forecast period of 2021 to 2027, with a CAGR of 18.7% in the forecast period of 2021 to 2027 and will expected to reach USD XXX million by 2027″ ...
- Potential mechanism underlying loss of muscle masson February 21, 2021 at 11:33 am
Estrogen deficiency alters the microRNA signalling in skeletal muscle which may activate signalling cascades leading to loss of muscle mass suggest the findin ...
via Bing News