via Wikipedia
A microRNA that regulates inflammation shows promise as a treatment for inflammatory diseases such as asthma and cancer, according to research published in Cell Reports.
The microRNA, known as miR-223, is highly expressed in blood cells that cause inflammation (neutrophils). When they’re working correctly, those blood cells help protect the human body against infections, but sometimes they damage host tissue instead of microbes, causing chronic inflammation and disease.
To uncover the link between miR-223 and inflammation, a Purdue University research team created a zebrafish totally deficient of miR-223. Then they cut off a small chunk of its fin.
“The inflammation was really robust,” said Qing Deng, a professor of biological sciences at Purdue and corresponding author of the paper. “Neutrophils accumulated at the wound and they just kept coming. This is consistent with the literature, but we wanted to understand why.”
Extensive gene expression analysis led them to pathway NF-kB, a protein complex found in nearly all animal cell types that regulates inflammation and cell proliferation. Heightened activation of this pathway is the cause of increased inflammation, although it’s limited to the deeper, or basal, layer of the epithelium. This means any therapeutics would need to reach the basal layer to work.
The same pathway plays an important role in human bronchial epithelial cells, which are critical in the development of asthma, according to the study. MiR-223 suppresses the pathway, which means supplementing it to epithelial cells could help control inflammatory disease.
“We don’t have human trials yet, but we think it’s promising,” Deng said. “Instead of using steroids to drive away the immune cells, maybe this microRNA could be given.”
Learn more: MicroRNA could help treat cancer and asthma
The Latest on: MicroRNA
via Google News
The Latest on: MicroRNA
- MicroRNA Agomir Synthesis: Supporting New Drug Research with Cutting-Edge Chemical Synthesis Technologyon July 29, 2022 at 1:46 pm
Creative Biogene announced the release of its microRNA agomir synthesis services which can be applied to support new drug research with cutting-edge chemical synthesis technology. New York, USA – July ...
- MicroRNA Agomir Synthesis: Supporting New Drug Research with Cutting-Edge Chemical Synthesis Technologyon July 29, 2022 at 11:50 am
Creative Biogene announced the release of its microRNA agomir synthesis services which can be applied to support new drug research with cutting-edge chemical synthesis technology. New York ...
- MicroRNA Let-7a Suppresses Breast Cancer Cell Migration and Invasion Through Downregulation of C-C Chemokine Receptor Type 7on July 26, 2022 at 5:00 pm
First, the let-7a binding site on CCR7 3'UTR was predicted by using the TargetScan microRNA-binding prediction program (Figure 6a). Next, the wild-type (WT) constructs containing let-7a binding ...
- A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemiaon July 20, 2022 at 5:00 pm
MicroRNA expression profiles can be used to distinguish normal B cells from malignant B cells in patients with chronic lymphocytic leukemia (CLL). We investigated whether microRNA profiles are ...
- MicroRNA Products Market 2022 Global Industry Size, Share, Revenue, Business Growth, Demand and Applications Market Research Report to 2027on July 20, 2022 at 5:31 am
Jul 20, 2022 (The Expresswire) -- The “MicroRNA Products Market” 2022 Research report will make detailed analysis mainly on in-depth research on the development environment, Market size ...
- Researchers Say MicroRNA Can Regrow 90% Of Lost Hairon July 15, 2022 at 7:41 am
A microRNA that might encourage hair regeneration has been found by researchers at North Carolina State University. This miRNA, miR-218-5p, could be a potential target for new drugs because it is ...
- Magnetic nanoparticles can release anti-cancer microRNA on commandon June 30, 2022 at 6:34 am
The payload in question is a short strand of RNA known as a microRNA. In this case, the researchers connected the nanoparticles to a synthetic version of a microRNA called miR-148b, which has been ...
- Nanoparticles can be triggered to release anti-cancer microRNA using an alternating magnetic fieldon June 30, 2022 at 5:19 am
Study shows that nanoparticles release an anti-cancer microRNA inside lung cancer cells when stimulated using an alternating magnetic field. Researchers are pursuing ever-more sophisticated ...
- MicroRNA (miRNA) Market Share 2022 Investigation by Demand Scope, CAGR of 10.5%, Growth Revenue, Size and Trends Forecast by Regions 2026on June 23, 2022 at 11:12 pm
Jun 24, 2022 (The Expresswire) -- The “MicroRNA (miRNA) Market” research study offers an in-depth and strategic analysis of industry segments by Type (Sample collection, miRNA cDNA Synthesis ...
- MicroRNA Market: Global Industry Analysis 2022-2028 by Types, Applications and Key Playerson June 21, 2022 at 4:55 am
MicroRNA market research report provides the details about Industry Chain structure, Market Competition, Market Size and Share, SWOT Analysis, Technology, Cost, Raw Materials, Consumer Preference ...
via Bing News