via Frontiers
The team lead by Sílvia Vilares Conde, from CEDOC-NOVA Medical School, in collaboration with the pharmaceutical company Galvani Bioelectronics, demonstrated through findings in rats that is possible to restore insulin sensitivity and glucose homeostasis, by modulating electrically the carotid sinus nerve, the sensitive nerve that connects the carotid body with the brain.
The study is published in Diabetologia, the journal of the European Association for the Study of Diabetes [EASD].
In 2013, Silvia Vilares Conde and her research group described that the carotid body, a paired organ that is located in the bifurcation of the common carotid artery and that is classically defined as an oxygen sensor, regulates peripheral insulin sensitivity and that its dysfunction is involved in the development of metabolic diseases.
This first study and others afterwards performed by her group in diabetic rats showed that the bilateral resection of the carotid sinus nerve, and therefore the abolishment of the connection between the carotid body and the brain, restore insulin sensitivity and glucose tolerance. Although efficient this surgical irreversible approach has disadvantages, since the carotid body possess other physiological functions as the response to the lack of oxygen (hypoxia) or the adaptation to exercise. Silvia Conde’s team also described that the carotid body is over-activated in animal models of type 2 diabetes, suggesting that decreasing the activity of the organ could be a good therapeutic strategy.
From the partnership with Galvani Bioelectronics (former Glaxo Smith Kline Bioelectronics), the opportunity to electrically modulate the carotid sinus nerve come up. In fact, this work demonstrated that is possible to maintain glucose homeostasis in animals in which electrodes have been implanted in the carotid sinus nerve and submitted to electrical modulation, without significant adverse effects. It has also been demonstrated that the electrical modulation is reversible. Silvia Conde notes that “this work opens the door to the development of a new therapeutic for type 2 diabetes that will provide a long-term management of the disease with negligible adverse effects and interference with daily activities”.
Type 2 diabetes is characterized by insulin resistance and by increased hepatic glucose production that culminates in hyperglycemia. Although a lot of efforts have been performed until the date none therapeutic induce long-term glycaemia control, being expected for the next decades a huge increase in the prevalence of the disease. Thus, this work gives hope to patients with metabolic diseases, as it brings a new approach for the management of type 2 diabetes.
Learn more: Electronic modulation of carotid sinus nerve can be used as a treatment for type 2 diabetes in rats
The Latest on: Type 2 diabetes
- What's the Difference Between Type 1 and Type 2 Diabetes?on October 11, 2021 at 2:30 pm
Diabetes is a condition where people have high blood sugar and are at risk for all kinds of serious complications as a result. But if you’ve ever had trouble remembering which is type 1 and which is ...
- Marked and widening socioeconomic inequalities in type 2 diabetes prevalence in Scotlandon October 11, 2021 at 2:09 pm
Background This study investigated the association between socioeconomic status and type 2 diabetes (T2D) prevalence in Scotland in 2021 and tested the null hypothesis that inequalities had not ...
- The experts weigh in on how to beat our obesity crisis: From weight loss surgery for children to recording everything you eat - what ARE the practical solutions to help ...on October 11, 2021 at 2:01 pm
The majority of the population is now battling a weight problem, with 68 per cent of men and 60 per cent of women an 'unhealthy' weight - that is, their body mass index (BMI) is more than 24.9.
- Diabetes type 2: A vegetable shown to help lower blood sugar by 10 percent – what to eaton October 11, 2021 at 8:14 am
DIABETES type 2 and diet are key when it comes to effectively managing the condition and lowering blood sugar. For a healthy diet, experts recommend one of the healthiest vegetables shown to help with ...
- Diabetes type 2 symptoms: These seven things could be a sign you have the conditionon October 11, 2021 at 5:54 am
THOUSANDS of people are likely living with type 2 diabetes with no idea. The condition can go undetected because its symptoms are hard to spot, or brushed off as something else. People can live ...
- Eat your breakfast at this hour to maintain type 2 diabeteson October 10, 2021 at 8:38 pm
If you have diabetes, it’s important to know that your diet is the most critical. Diabetes is a lifestyle disease that is spreading across the globe like wildfire. For the uninitiated, it is a ...
- Statin use associated with type 2 diabetes progressionon October 7, 2021 at 10:05 am
Researchers have found associations between statins and decreased insulin sensitivity, which can lead to type 2 diabetes. In the present study, the team found people with type 2 diabetes who took ...
- 6 Natural Type 2 Diabetes Remedies - And The Whys And Whereforeson October 7, 2021 at 2:07 am
Alright, I've been extremely lucky and have never actually endured with this specific weakening and progressively growing, wellbeing annihilating infirmity - the couple of times my glucose has hit a ...
- Type 2 Diabetes Management Should Include 15 Percent Weight Loss, Researchers Sayon October 6, 2021 at 2:10 pm
Experts say a 15 percent weight loss isn't easy to obtain or maintain, so lifestyle interventions are needed for most people with type 2 diabetes ...
- One in 10 in the UK will have diabetes by 2030, charity warns – 4 things to do now to avoid Type 2 diabeteson October 6, 2021 at 5:42 am
As Diabetes UK warns urgent action is needed to prevent diabetes, these lifestyle steps can help reduce your risk of developing the disease.
via Google News and Bing News
