
via Frontiers
The team lead by Sílvia Vilares Conde, from CEDOC-NOVA Medical School, in collaboration with the pharmaceutical company Galvani Bioelectronics, demonstrated through findings in rats that is possible to restore insulin sensitivity and glucose homeostasis, by modulating electrically the carotid sinus nerve, the sensitive nerve that connects the carotid body with the brain.
The study is published in Diabetologia, the journal of the European Association for the Study of Diabetes [EASD].
In 2013, Silvia Vilares Conde and her research group described that the carotid body, a paired organ that is located in the bifurcation of the common carotid artery and that is classically defined as an oxygen sensor, regulates peripheral insulin sensitivity and that its dysfunction is involved in the development of metabolic diseases.
This first study and others afterwards performed by her group in diabetic rats showed that the bilateral resection of the carotid sinus nerve, and therefore the abolishment of the connection between the carotid body and the brain, restore insulin sensitivity and glucose tolerance. Although efficient this surgical irreversible approach has disadvantages, since the carotid body possess other physiological functions as the response to the lack of oxygen (hypoxia) or the adaptation to exercise. Silvia Conde’s team also described that the carotid body is over-activated in animal models of type 2 diabetes, suggesting that decreasing the activity of the organ could be a good therapeutic strategy.
From the partnership with Galvani Bioelectronics (former Glaxo Smith Kline Bioelectronics), the opportunity to electrically modulate the carotid sinus nerve come up. In fact, this work demonstrated that is possible to maintain glucose homeostasis in animals in which electrodes have been implanted in the carotid sinus nerve and submitted to electrical modulation, without significant adverse effects. It has also been demonstrated that the electrical modulation is reversible. Silvia Conde notes that “this work opens the door to the development of a new therapeutic for type 2 diabetes that will provide a long-term management of the disease with negligible adverse effects and interference with daily activities”.
Type 2 diabetes is characterized by insulin resistance and by increased hepatic glucose production that culminates in hyperglycemia. Although a lot of efforts have been performed until the date none therapeutic induce long-term glycaemia control, being expected for the next decades a huge increase in the prevalence of the disease. Thus, this work gives hope to patients with metabolic diseases, as it brings a new approach for the management of type 2 diabetes.
Learn more: Electronic modulation of carotid sinus nerve can be used as a treatment for type 2 diabetes in rats
The Latest on: Type 2 diabetes
[google_news title=”” keyword=”type 2 diabetes” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
- Study links high dietary amino acid intake to increased type 2 diabetes riskon November 22, 2023 at 5:28 am
A significant link was observed between a high intake of certain amino acids (branched-chain, alkaline, sulfuric, and essential) and increased T2D risk, particularly in the highest intake quartile.
- Type 2 diabetes: quitting this habit could reduce your risk of diabetes by 40%on November 22, 2023 at 2:42 am
Just over four million people live with diabetes in the UK - and a lifestyle change could prevent that number growing ...
- Mom missed the signs her son had Type 1 diabetes. A co-worker may’ve saved his lifeon November 22, 2023 at 2:11 am
Mom thought son was thirsty because of a heatwave. Her coworkers knew it was a sign of type 1 diabetes. He was diagnosed before developing diabetic ketoacidosis ...
- Type 2 Diabetes Linked to Increased Colorectal Cancer Risk in Black, Low-Income Adultson November 21, 2023 at 10:42 am
New research found a link between type 2 diabetes and colorectal cancer risk in African Americans with low socioeconomic status. The strongest association was detected in participants with recent ...
- Raising awareness of Diabeteson November 21, 2023 at 4:48 am
And, on Nov 15, the Cochrane Lions Club had a booth at Wallace Drug Store handing out pamphlets on educating residents on diabetes. They also were taking donations for Diabetes Canada. They were able ...
- Type 2 Diabetes Newson November 20, 2023 at 9:01 am
Discover how automated insulin delivery (AID) benefits type 1 diabetes and ongoing trials assessing the impact of AID systems on type 2 diabetes management. Orforglipron, Eli Lilly's once-daily oral ...
- The simple thing you can do each night to reduce your risk of type 2 diabeteson November 20, 2023 at 4:11 am
Getting an adequate amount of sleep each night could be key in reducing your risk of type 2 diabetes. This was the result of a study published in Diabetes Care. Previous research has shown sleep loss ...
- When my son developed Type 1 diabetes our family life changed foreveron November 20, 2023 at 12:00 am
It started during the Easter holidays in 2019. My wife Becky and I had just returned from a short break in the New Forest with our children, and we’d both remarked on the number of times our ...
- Managing the risks of heart disease when living with type 2 diabeteson November 19, 2023 at 4:01 pm
One of the most important health risks for people with type 2 diabetes to be aware of is heart disease, as those living with type 2 diabetes face an increased risk of dying from heart disease at an ...
- These Types of Exercises Lower Risk of Type 2 Diabetes, Study Findson November 18, 2023 at 5:00 am
Moderate to vigorous exercise can lower your risk of developing type 2 diabetes, a new study finds. Experts explain what you need to know.
via Google News and Bing News